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Invitrogen
Villin Polyclonal Antibody
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产品信息
PA5-22072
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
C. elegans,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the N-terminus region of human Villin. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
0.85 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: HepG2, mouse kidney, rat kidney.
Predicted reactivity: Mouse (89%), Rat (89%), Bovine (90%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Villin is part of cytoskeleton associated with the microvillar actin core bundle of gastrointestinal and renal brush border. It can interact with actin in a Ca2+ and phosphoinositide-regulated manner. Villin is a very specific marker for adenocarcinomas of the gastrointestinal tract and the pancreas. It is also expressed in some Merkel cell tumor and adenocarcinoma of the lung, prostate, ovarian and kidney.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: OTTHUMP00000207159; Villin-1
基因别名: D2S1471; VIL; VIL1
UniProt ID: (Human) Q53S11, (Mouse) Q62468
Entrez Gene ID: (Human) 7429, (Mouse) 22349, (Rat) 316521
calcium ion binding
protein binding
phosphatidylinositol-4,5-bisphosphate binding
lysophosphatidic acid binding
identical protein binding
protein homodimerization activity
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
actin filament binding
actin binding
metal ion binding
molecular_function
non-motor actin binding protein
intestinal D-glucose absorption
protein complex assembly
apoptotic process
epidermal growth factor receptor signaling pathway
regulation of cell shape
response to bacterium
positive regulation of epithelial cell migration
actin filament polymerization
actin filament depolymerization
positive regulation of cell migration
positive regulation of actin filament depolymerization
epithelial cell differentiation
positive regulation of actin filament bundle assembly
regulation of microvillus length
cellular response to hepatocyte growth factor stimulus
positive regulation of multicellular organism growth
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
actin nucleation
actin filament severing
barbed-end actin filament capping
regulation of actin nucleation
actin filament capping
cytoplasmic actin-based contraction involved in cell motility
regulation of wound healing
cellular response to epidermal growth factor stimulus
positive regulation of establishment of protein localization to plasma membrane
terminal web assembly
regulation of lamellipodium morphogenesis
positive regulation of lamellipodium morphogenesis
cytoskeleton organization
microvillus assembly
biological_process
