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Peptide sequence: WKRALPARLA EKSRAEEAGA PGGPRQPRAD RCPPPPRTLP PGACQAARCQ
Sequence homology: Dog: 91%; Human: 100%
This gene encodes a member of the WAP-type four disulfide core domain family. The WAP-type four-disulfide core domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. The encoded protein shares 81% amino acid identity with the rat ps20 protein, which was originally identified as a secreted growth inhibitor. This gene is mapped to chromosome 16q24, an area of frequent loss of heterozygosity in cancers, including prostate, breast and hepatocellular cancers and Wilms' tumor. Owing to its location and a possible growth inhibitory property of its gene product, this gene is suggested to be a tumor suppressor gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Prostate stromal protein ps20; ps20 growth inhibitor; WAP four-disulfide core domain 1 homolog; WAP four-disulfide core domain protein 1
基因别名: PS20; WFDC1
UniProt ID: (Human) Q8NC27
Entrez Gene ID: (Human) 58189