Invitrogen

YAP1 Polyclonal Antibody

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18个已发表图片
26 篇参考文献
查看其他43个YAP1抗体

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说明书
实验方案
问题与答案
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说明书
实验方案
问题与答案
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说明书
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产品信息

PA1-46189

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000
查看8篇已发表文章 8篇已发表文章

免疫组化 (IHC)

-
查看5篇已发表文章 5篇已发表文章

免疫组化（石蜡） (IHC (P))

1:50-1:200
查看1篇已发表文章 1篇已发表文章

免疫细胞化学 (ICC/IF)

1:500
查看7篇已发表文章 7篇已发表文章

免疫沉淀 (IP)

2-10 µg
查看1篇已发表文章 1篇已发表文章

染色质免疫沉淀 实验 (ChIP)

1.5 µg/10^6 cells
查看3篇已发表文章 3篇已发表文章

亲和纯化 (AP)

-
查看1篇已发表文章 1篇已发表文章
产品规格

种属反应

Dog, Human, Mouse, Rat, Zebrafish

已发表种属

C. elegans, Human, Rat, Zebrafish

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Partial recombinant human YAP1 protein expressed in bacteria.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.0 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS

内含物

0.02% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2219137

产品详细信息

Suggested positive control: brain and kidney lysates, and HEK 293 cell lysate, 293 whole cell lysate, antigen standard for YAP1 (transient overexpression lysate), human kidney protein, human brain protein.

靶标信息

YAP (Yes-Associated Protein) is a founding member of the WW domain family of proteins, transcriptional co-activator and oncogene. Its gene is transcriptionally activated in squamous cell carcinoma cells. YAP can act both as a coactivator and corepressor and is the critical downstream regulatory target in the Hippo signaling pathway. The Hippo signaling pathway plays a pivotal role in organ size control and tumour suppression by restricting proliferation and promoting apoptosis. Also plays key roles in tissue tension, 3D tissue shape, cell proliferation, cell death, and cell migration. Mutations in the IRF5 gene results in coloboma.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: 65 kDa Yes-associated protein; Protein yorkie homolog; Transcriptional coactivator YAP1; yap; Yes associated protein 1; Yes-associated protein 1; Yes-associated protein 1, 65kDa; yes-associated protein 2; Yes-associated protein YAP65 homolog; yes-associated protein, 65 kDa; yorkie homolog

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基因别名: AI325207; cb194; CH211-181P1.5-001; COB1; sb:cb194; si:ch211-181p1.5; si:dkey-3b8.3; wu:fc18c04; YAP; YAP1; YAP2; YAP65; YKI; Yorkie; zgc:158380; zYAP

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UniProt ID: (Human) P46937, (Mouse) P46938, (Zebrafish) Q1L8J7

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Entrez Gene ID: (Dog) 479465, (Human) 10413, (Rat) 363014, (Mouse) 22601, (Zebrafish) 561411

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功能
RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity, RNA polymerase II transcription factor binding chromatin binding transcription coactivator activity transcription corepressor activity protein binding protein C-terminus binding transcription regulatory region DNA binding proline-rich region binding transcription cofactor
参与通路
cell morphogenesis vasculogenesis embryonic heart tube morphogenesis transcription initiation from RNA polymerase II promoter cellular response to DNA damage stimulus cell proliferation positive regulation of cell proliferation regulation of keratinocyte proliferation keratinocyte differentiation negative regulation of epithelial cell differentiation notochord development somatic stem cell population maintenance hippo signaling positive regulation of transcription from RNA polymerase II promoter positive regulation of organ growth paraxial mesoderm development lateral mesoderm development regulation of neurogenesis contact inhibition bud elongation involved in lung branching lung epithelial cell differentiation cellular response to retinoic acid cellular response to gamma radiation regulation of stem cell proliferation regulation of metanephric nephron tubule epithelial cell differentiation positive regulation of canonical Wnt signaling pathway positive regulation of stem cell population maintenance negative regulation of nucleic acid-templated transcription negative regulation of stem cell differentiation negative regulation of extrinsic apoptotic signaling pathway transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter DNA damage induced protein phosphorylation regulation of cell proliferation regulation of canonical Wnt signaling pathway liver development secondary heart field specification ventriculo bulbo valve development retinal pigment epithelium development brain development endoderm development dorsal/ventral axis specification negative regulation of gene expression BMP signaling pathway pancreas development fin regeneration embryonic hemopoiesis pronephric duct development glucose homeostasis negative regulation of apoptotic process regulation of organ growth blood vessel morphogenesis posterior lateral line development cartilage development cilium morphogenesis heart formation positive regulation of glutamate-ammonia ligase activity
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