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Invitrogen
ZNF554 Polyclonal Antibody
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ZNF554 Antibody (PA5-30907) in ICC/IF
ZNF554 Polyclonal Antibody detects ZNF554 protein at nucleus by immunofluorescent analysis. Sample: MCF-7 cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: ZNF554 protein stained by ZNF554 Polyclonal Antibody (Product # PA5-30907) diluted at 1:500. Blue: Hoechst 33342 staining. Scale bar = 10 µm.
产品信息
PA5-30907
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human ZNF554. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 1% BSA, 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: PC-3.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
ZNF554, or Zinc Finger Protein 554, is a member of the Kruppel-associated box domain-zinc finger proteins (KRAB-ZNF) subfamily, residing on chromosome 19p13. This region is characterized by a concentration of heterochromatin proteins, which indicates tightly regulated gene expression. ZNF554 is implicated in various cellular processes including transcription regulation and apoptosis. Dysregulation of ZNF554 has been linked to several diseases; notably, its decreased expression is associated with poor prognosis in gliomas, specifically grades III and IV astrocytomas, where it affects the PI3K-Akt signaling pathway. It also plays a role in placental development, with dysfunction contributing to conditions such as fetal growth restriction (FGR). Additionally, ZNF554 transcription is influenced by factors like ZEB1, ZEB2, and hypoxic conditions, with neighboring hypoxia-response elements showing hypermethylation in preeclampsia. This gene's expression can significantly alter the transcriptional landscape, with overexpression leading to the differential regulation of hundreds of genes, underscoring its importance in cellular regulation.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLJ34817; Zinc finger protein 554
基因别名: ZNF554
UniProt ID: (Human) Q86TJ5
Entrez Gene ID: (Human) 115196
