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beta Adaptin/AP2 beta Polyclonal Antibody
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产品信息
BS-1546R
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide derived from human beta Adaptin, amino acids 351-450.
偶联物
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
内含物
0.02% ProClin 300
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Clathrin-mediated endocytosis is the pathway by which many receptors for nutrients and hormones are internalized to be recycled or down-regulated. During formation of clathrin coated membranes, clathrin co-assembles with heterotetrameric molecules known as assembly polypeptides (APs) or adaptors which form a layer of protein coat between the clathrin lattice and the membrane. There are two characterized adaptors AP1 and AP2. AP1 is associated with clathrin coated vesicles at the trans-Golgi network and AP2 is associated with the endocytic clathrin coated vesicles at the plasma membrane and has been shown to specifically interact with Shc and EGF receptor. AP2 is composed of four subunits, two separate ~100 kDa gene products with similar domain structures (alpha and beta adaptin) and a ~50 and ~17 kDa subunit. There are two alpha-adaptin genes, alpha A and alpha C which have a tissue specific pattern of expression.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: adapter-related protein complex 2 beta subunit; adapter-related protein complex 2 subunit beta; adaptin, beta 2 (beta); Adaptor protein complex AP-2 subunit beta; adaptor related protein complex 2 beta 1 subunit; Adaptor-related protein complex 2 subunit beta; AP-2 complex subunit beta; AP105B; beta adaptin; Beta-2-adaptin; Beta-adaptin; beta2-adaptin; Clathrin assembly protein complex 2 beta large chain; clathrin-associated/assembly/adaptor; clathrin-associated/assembly/adaptor protein, large, beta 1; Plasma membrane adaptor HA2/AP2 adaptin beta subunit; testicular tissue protein Li 22; unnamed protein product
基因别名: 1300012O03Rik; ADTB2; AI788979; AP105B; AP2-BETA; AP2B1; CLAPB1
UniProt ID: (Human) P63010, (Rat) P62944, (Mouse) Q9DBG3
Entrez Gene ID: (Human) 163, (Rat) 140670, (Mouse) 71770
kidney development
cardiac septum development
ventricular septum development
intracellular protein transport
endocytosis
chemical synaptic transmission
neurotransmitter secretion
heart development
protein transport
vesicle-mediated transport
aorta development
positive regulation of endocytosis
clathrin coat assembly
synaptic vesicle endocytosis
coronary vasculature development
clathrin-mediated endocytosis
postsynaptic neurotransmitter receptor internalization
positive regulation of protein localization to membrane
transport
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