Invitrogen

c-Abl Recombinant Monoclonal Antibody (PSH04-08)

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c-Abl Recombinant Monoclonal Antibody (PSH04-08)

产品信息

MA562904

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000
-

免疫组化（石蜡） (IHC (P))

1:200
-

免疫细胞化学 (ICC/IF)

1:100
-

流式细胞分析 (Flow)

1:1,000
-
产品规格

种属反应

Human, Mouse

宿主/亚型

Artificial Control / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

PSH04-08

抗原

Recombinant protein within human ABL1 aa 601-1,000 / 1,130.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.4, with 0.1% BSA, 40% glycerol

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Positive Control: K-562 cell lysate, HeLa cell lysate, Daudi cell lysate, THP-1 cell lysate, K-562, human breast cancer tissue, human lung cancer tissue, mouse kidney tissue, HeLa.

Tissue Specificity: Low tissue specificity.

Subcellular Location: Cytoplasm, cytoskeleton, Nucleus, Mitochondrion; Nucleus membrane.

Sequence Similarities: 73% Mouse/Rat.

Predicted band size: 123 kDa

靶标信息

The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns c-Abl into an oncogene. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for c-Abl. In chronic myelogenous leukemia and a subset of acute lymphoblastic leukemias, the c-Abl proto oncogene undergoes a (9;22) chromosomal translocation producing a novel rearranged chromosome (the Philadelphia chromosome). As the result of the fusion of c-Abl sequences from chromosome 9 to the Bcr gene on chromosome 22. The c-Abl oncogene was initially identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV). c-ABL potentially regulates DNA repair by activating the proapoptotic pathway when the DNA damage is too severe to be repaired.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: Abelson murine leukemia oncogene; Abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; Abl 1 antib; ABL2; ABLL; ARG; B30; bcr/c-abl oncogene protein; c-abl oncogene 1, receptor tyrosine kinase; p150; Proto-oncogene c-Abl; proto-oncogene tyrosine-protein kinase ABL1; RP11-83J21.1; Tyrosine kinase ARG; Tyrosine-protein kinase ABL1; v-abl Abelson murine leukemia oncogene 1; v-abl Abelson murine leukemia viral oncogene homolog 1

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基因别名: ABL; ABL1; AI325092; bcr/abl; c-ABL; c-ABL1; E430008G22Rik; JTK7; p150; v-abl

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UniProt ID: (Human) P00519, (Mouse) P00520

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Entrez Gene ID: (Human) 25, (Mouse) 11350

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功能
magnesium ion binding DNA binding actin monomer binding nicotinate-nucleotide adenylyltransferase activity protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity protein kinase C binding receptor binding protein binding ATP binding protein C-terminus binding SH3 domain binding syntaxin binding manganese ion binding actin filament binding mitogen-activated protein kinase binding proline-rich region binding nucleotide binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups protein kinase binding protein domain specific binding metal ion binding delta-catenin binding
参与通路
B-1 B cell homeostasis positive regulation of protein phosphorylation B cell proliferation involved in immune response transitional one stage B cell differentiation mismatch repair regulation of transcription, DNA-templated cellular protein modification process autophagy cellular response to DNA damage stimulus DNA damage induced protein phosphorylation response to oxidative stress cell cycle arrest mitotic nuclear division epidermal growth factor receptor signaling pathway positive regulation of cytosolic calcium ion concentration intrinsic apoptotic signaling pathway in response to DNA damage regulation of autophagy peptidyl-tyrosine phosphorylation cerebellum morphogenesis negative regulation of cell-cell adhesion microspike assembly actin cytoskeleton organization regulation of endocytosis regulation of cell adhesion negative regulation of BMP signaling pathway regulation of axon extension regulation of microtubule polymerization regulation of actin cytoskeleton organization positive regulation of osteoblast proliferation substrate adhesion-dependent cell spreading cellular response to oxidative stress platelet-derived growth factor receptor-beta signaling pathway peptidyl-tyrosine autophosphorylation Fc-gamma receptor signaling pathway involved in phagocytosis regulation of cell proliferation signal transduction in response to DNA damage positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB kinase/NF-kappaB signaling innate immune response establishment of protein localization negative regulation of mitotic cell cycle positive regulation of mitotic cell cycle alpha-beta T cell differentiation protein autophosphorylation spleen development thymus development collateral sprouting positive regulation of peptidyl-tyrosine phosphorylation activated T cell proliferation B cell receptor signaling pathway neuromuscular process controlling balance positive regulation of muscle cell differentiation positive regulation of release of sequestered calcium ion into cytosol positive regulation of oxidoreductase activity negative regulation of ubiquitin-protein transferase activity mitochondrial depolarization Bergmann glial cell differentiation cellular response to hydrogen peroxide negative regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade cellular response to lipopolysaccharide negative regulation of protein serine/threonine kinase activity actin filament branching positive regulation of interleukin-2 secretion negative regulation of phospholipase C activity positive regulation of neuron death positive regulation of interferon-gamma secretion regulation of extracellular matrix organization cellular response to dopamine positive regulation of microtubule binding positive regulation of actin filament binding activation of protein kinase C activity positive regulation of Wnt signaling pathway, planar cell polarity pathway regulation of cell motility regulation of actin cytoskeleton reorganization negative regulation of endothelial cell apoptotic process negative regulation of cellular senescence regulation of response to DNA damage stimulus DNA repair protein phosphorylation endocytosis phagocytosis apoptotic process cell adhesion phosphorylation cell migration B cell proliferation platelet-derived growth factor receptor signaling pathway regulation of cell cycle regulation of cellular senescence
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