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c-Myb Polyclonal Antibody

View all (25) Myb antibodies

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Product Details

600-401-B06

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,500
-

ELISA (ELISA)

1:10,000-1:20,000
-
Product Specifications

Species Reactivity

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a peptide corresponding to an internal portion of mouse c-Myb protein.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.51 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

0.02M potassium phosphate, pH 7.2, with 0.15M NaCl

Contains

0.01% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

This antibody reacts with endogenous c-Myb protein and also SUMOylated overexpressed c-Myb protein in transfected Cos7 cells. A BLAST analysis was used to suggest reactivity with c-Myb from mouse based on a 100% homology with the immunizing sequence. Expect reactivity with c-Myb from rat, pig, human, horse, platypus, opossum, orangutan, spider monkey, bonobo, gorilla, and chimpanzee; with a v-myb myeloblastosis viral oncogene homolog, all isoforms (also avian version) from human; and with a protooncogene c-myb, and a v-myb myeloblastosis viral oncogene homolog (avian), both from cattle, all based on a 93% homology with the immunizing sequence. Cross-reactivity with c-Myb from other sources has not been determined.

Target Information

Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: c-myb10A_CDS; c-myb13A_CDS; c-myb14A_CDS; c-myb8B_CDS; gag-myb protein; mutant; myb proto-oncogene protein; myeloblastosis oncogene; myeloblastosis proto-oncogene product; proto-oncogene c-Myb; RP1-32B1.1; tumor-specific myb protein; unnamed protein product

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Gene Aliases: c-myb

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UniProt ID: (Mouse) P06876

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Entrez Gene ID: (Mouse) 17863

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding WD40-repeat domain binding
Process(es)
G1/S transition of mitotic cell cycle negative regulation of transcription from RNA polymerase II promoter mitotic cell cycle response to hypoxia in utero embryonic development response to ischemia regulation of transcription, DNA-templated calcium ion transport regulation of gene expression skeletal muscle cell proliferation stem cell division myeloid cell differentiation B cell differentiation erythrocyte differentiation positive regulation of collagen biosynthetic process positive regulation of neuron apoptotic process T-helper 2 cell differentiation negative regulation of megakaryocyte differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter spleen development thymus development embryonic digestive tract development positive regulation of smooth muscle cell proliferation homeostasis of number of cells positive regulation of glial cell proliferation myeloid cell development cellular response to hydrogen peroxide cellular response to retinoic acid cellular response to interleukin-6 positive regulation of transforming growth factor beta production negative regulation of hematopoietic progenitor cell differentiation positive regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of hepatic stellate cell proliferation cellular response to leukemia inhibitory factor positive regulation of hepatic stellate cell activation positive regulation of testosterone secretion
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