Invitrogen

pan Synuclein Polyclonal Antibody

高级验证

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说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持

产品信息

PA5-78420

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:3,000
-

免疫组化（石蜡） (IHC (P))

1:100-1:1,000
-

免疫组化（冰冻） (IHC (F))

1:100-1:1,000
-

免疫细胞化学 (ICC/IF)

1:100-1:1,000
-
产品规格

种属反应

Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein encompassing a sequence within the center region of Rat pan Synuclein. The exact sequence is proprietary.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.2 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7, with 20% glycerol, 1% BSA

内含物

0.025% ProClin 300

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2736318

产品详细信息

Positive Control: mouse brain, rat brain

Predicted Reactivity: Human (93%), Xenopus laevis (84%), Pig (92%), Chicken (87%), Sheep (91%), Chimpanzee (93%), Bovine (91%)

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

Synucleins are small, soluble proteins expressed primarily in neural tissue and in certain tumors. The family includes three known proteins: alpha-synuclein, beta-synuclein, and gamma-synuclein. The alpha- and beta-synuclein proteins are found primarily in brain tissue, where they are seen mainly in presynaptic terminals. The gamma-synuclein protein is found primarily in the peripheral nervous system and retina, but its expression in breast tumors makes it a candidate as a marker for tumor progression.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Alpha-synuclein; Beta-synuclein; Gamma-synuclein; NACP; Non-A beta component of AD amyloid; non-A4 component of amyloid; Non-A4 component of amyloid precursor; Persyn; Phosphoneuroprotein 14; PNP 14; Sensory neuron synuclein; synuclein, gamma (breast cancer-specific protein 1)

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基因别名: AI838531; alphaSYN; betaSYN; C79089; NACP; Persyn; Snca; Sncb; Sncg; Syn

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UniProt ID: (Rat) P37377, (Mouse) O55042, (Mouse) Q91ZZ3, (Rat) Q63754, (Rat) Q63544, (Mouse) Q9Z0F7

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Entrez Gene ID: (Rat) 29219, (Mouse) 20617, (Mouse) 104069, (Rat) 113893, (Rat) 64347, (Mouse) 20618

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功能
magnesium ion binding fatty acid binding copper ion binding calcium ion binding protein binding phospholipid binding microtubule binding ferrous iron binding zinc ion binding oxidoreductase activity kinesin binding enzyme binding protein domain specific binding Hsp70 protein binding histone binding identical protein binding alpha-tubulin binding cysteine-type endopeptidase inhibitor activity involved in apoptotic process phospholipase binding dynein binding protein N-terminus binding tau protein binding beta-tubulin binding arachidonic acid binding phosphoprotein binding phospholipase D inhibitor activity metal ion binding membrane trafficking regulatory protein
参与通路
microglial cell activation positive regulation of receptor recycling negative regulation of protein phosphorylation positive regulation of neurotransmitter secretion synaptic transmission, dopaminergic fatty acid metabolic process neutral lipid metabolic process phospholipid metabolic process activation of cysteine-type endopeptidase activity involved in apoptotic process mitochondrial membrane organization chemical synaptic transmission aging adult locomotory behavior response to iron(II) ion regulation of phospholipase activity negative regulation of platelet-derived growth factor receptor signaling pathway regulation of glutamate secretion regulation of dopamine secretion negative regulation of microtubule polymerization receptor internalization protein destabilization response to magnesium ion negative regulation of transporter activity response to lipopolysaccharide negative regulation of monooxygenase activity positive regulation of peptidyl-serine phosphorylation response to interferon-gamma cellular response to oxidative stress negative regulation of histone acetylation regulation of locomotion response to cocaine dopamine biosynthetic process dopamine metabolic process response to drug mitochondrial ATP synthesis coupled electron transport regulation of macrophage activation negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of neuron apoptotic process negative regulation of neuron apoptotic process cellular response to fibroblast growth factor stimulus positive regulation of endocytosis negative regulation of exocytosis negative regulation of dopamine metabolic process regulation of neurotransmitter secretion behavioral response to cocaine regulation of neuronal synaptic plasticity regulation of long-term neuronal synaptic plasticity synaptic vesicle endocytosis synaptic vesicle transport positive regulation of synaptic transmission synapse organization regulation of acyl-CoA biosynthetic process positive regulation of release of sequestered calcium ion into cytosol negative regulation of dopamine uptake involved in synaptic transmission negative regulation of serotonin uptake negative regulation of norepinephrine uptake calcium ion homeostasis oxidation-reduction process excitatory postsynaptic potential long-term synaptic potentiation positive regulation of inositol phosphate biosynthetic process membrane organization negative regulation of thrombin receptor signaling pathway response to interleukin-1 cellular response to copper ion positive regulation of protein serine/threonine kinase activity regulation of neuron death positive regulation of glutathione peroxidase activity positive regulation of hydrogen peroxide catabolic process regulation of reactive oxygen species metabolic process aggressive behavior peripheral nervous system development protein secretion cellular response to hydrostatic pressure
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