{"id":1085,"date":"2026-03-20T08:32:24","date_gmt":"2026-03-20T08:32:24","guid":{"rendered":"https:\/\/www.thermofisher.com\/blog\/accelerating-science-in-china\/?p=1085"},"modified":"2026-04-22T21:59:28","modified_gmt":"2026-04-22T21:59:28","slug":"t-cell-activation","status":"publish","type":"post","link":"https:\/\/www.thermofisher.cn\/blog\/t-cell-activation\/","title":{"rendered":"T\u7ec6\u80de\u6fc0\u6d3b\u7684\u79d8\u7c4d\uff0c\u6d41\u5f0f\u5fc5\u770b\uff01"},"content":{"rendered":"\n

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\"\"<\/figure>\n\n\n\n

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\"\"<\/figure>\n\n\n\n

\u56fe2. T \u7ec6\u80de\u523a\u6fc0[2]<\/sup><\/p>\n\n\n\n

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\u6b65\u9aa4 I\uff1a\u6297\u4f53\u5305\u88ab96\u5b54\u677f<\/strong><\/h3>\n\n\n\n
    \n
  1. \u5728\u65e0\u83cc PBS \u4e2d\u5236\u5907 5-10 \u00b5g\/mL anti-CD3\uff08\u8d27\u53f7#16-0031-82\uff09\u6eb6\u6db2\u3002Note\uff1a\u5efa\u8bae\u8fdb\u884c\u9884\u5b9e\u9a8c\uff0c\u4ee5\u786e\u5b9a\u5176\u4ed6\u6d53\u5ea6CD3\u6297\u4f53\u8bf1\u5bfc\u7ec6\u80de\u6d3b\u5316\u7684\u529f\u6548\u3002<\/li>\n\n\n\n
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  3. \u5c01\u53e3\u819c\u5bc6\u5c0196\u5b54\u677f\u4ee5\u907f\u514d\u6db2\u4f53\u84b8\u53d1\uff0c37\u00b0C\u4e0b\u5b75\u80b22 h\uff0c\u6216\u63d0\u524d\u4e00\u5929\u51c6\u5907\u5e76\u5728 4\u00b0C \u4e0b\u4fdd\u5b58\u8fc7\u591c\u3002<\/li>\n\n\n\n
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  5. \u7528 200 \u00b5L \u65e0\u83cc PBS \u51b2\u6d17\u6bcf\u4e2a\u5b54\u5e76\u4e22\u5f03 PBS\u3002<\/li>\n\n\n\n
  6. \u91cd\u590d\u4e0a\u8ff0\u6b65\u9aa4\u3002<\/li>\n<\/ol>\n\n\n\n

    \u6b65\u9aa4 II\uff1a\u6dfb\u52a0\u7ec6\u80de<\/strong><\/h3>\n\n\n\n
      \n
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    2. \u7528 PBS \u6e05\u6d17\u5b54\u540e\uff08\u4e0a\u8ff0\u6b65\u9aa4 6\uff09\uff0c\u5411\u6bcf\u4e2a\u5b54\u4e2d\u6dfb\u52a0 100 \u00b5L \u7ec6\u80de\u60ac\u6d6e\u6db2\uff08\u4e0d\u540c\u6761\u4ef6\u6ce8\u610f\u8bbe\u7f6e\u590d\u5b54\uff09\u3002<\/li>\n\n\n\n
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    4. \u653e\u5165 37\u00b0C\u30015% CO2<\/sub> \u57f9\u517b\u7bb1\u4e2d\uff0c\u5b75\u80b2 2-4\u5929\u3002Note\uff1a\u5b75\u80b2\u65f6\u95f4\u9700\u8981\u6839\u636e\u5b9e\u9a8c\u9700\u6c42\u8fdb\u884c\u4f18\u5316\uff0c\u6ce8\u610f\u89c2\u5bdf\u7ec6\u80de\u72b6\u6001\u548c\u57f9\u517b\u57fa\u989c\u8272\uff0c\u53ca\u65f6\u66f4\u6362\u65b0\u9c9c\u57f9\u517b\u57fa\u3002<\/li>\n\n\n\n
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      Question & Answer<\/strong><\/h2>\n\n\n\n

      Q \u4e0a\u8ff0\u6297\u4f53\u523a\u6fc0\u65b9\u6848\u53ef\u4ee5\u5c06T\u7ec6\u80de\u6269\u589e\u591a\u5c11\u500d\uff1f<\/strong><\/p>\n\n\n\n

      A \u4e00\u822c\u6765\u8bb2\uff0c\u81f3\u5c11\u51e0\u5341\u500d\u7684\u6269\u589e\u500d\u6570\u662f\u53ef\u4ee5\u5b9e\u73b0\u7684\u3002\u4f46\u8fd9\u540c\u65f6\u4e5f\u4e0e\u7ec6\u80de\u6765\u6e90\u3001\u72b6\u6001\uff0c\u4ee5\u53ca\u6297\u4f53\u6d53\u5ea6\u548c\u6fc0\u6d3b\u65f6\u95f4\u606f\u606f\u76f8\u5173\u3002<\/p>\n\n\n\n

      Q \u6297\u539f\u63d0\u5448\u7684\u65b9\u6cd5\u4e0e\u7528CD3\/CD28\u6297\u4f53\u6d3b\u5316\u6709\u4ec0\u4e48\u533a\u522b\uff1f<\/strong><\/p>\n\n\n\n

      A<\/strong> \u5229\u7528\u6297\u539f\u63d0\u5448\u65b9\u6cd5\u6d3b\u5316\u7684T\u7ec6\u80de\u662f\u67d0\u4e2a\u6297\u539f\u7279\u5f02\u6027\u7684\u7ec6\u80de\uff0c\u8fd9\u90e8\u5206\u7ec6\u80de\u6bd4\u4f8b\u504f\u4f4e\uff0c\u800cCD3\/CD28\u6d3b\u5316\u7684T\u7ec6\u80de\u662f\u591a\u514b\u9686\u7684\uff0c\u4ece\u800c\u80fd\u591f\u83b7\u5f97\u8f83\u591a\u7684T\u7ec6\u80de\u3002<\/p>\n\n\n\n

      Q \u5728\u4ec0\u4e48\u65f6\u95f4\u8be5\u7ed9T\u7ec6\u80de\u8fdb\u884c\u8865\u6db2\u6216\u8005\u6362\u6db2\u5462\uff1f<\/strong><\/p>\n\n\n\n

      A <\/strong>\u6fc0\u6d3b\u8fc7\u7a0b\u4e2d\uff0c\u9700\u6bcf\u5929\u89c2\u5bdf\u7ec6\u80de\u662f\u5426\u5f62\u6210\u514b\u9686\u56e2\u3002\u53ef\u4ee5\u5bf9\u7ec6\u80de\u8fdb\u884c\u8ba1\u6570\uff0c\u5982\u679c\u51fa\u73b0\u57f9\u517b\u57fa\u53d8\u9ec4\u6216\u7ec6\u80de\u5bc6\u5ea6\u8fc7\u9ad8\u7684\u60c5\u51b5\uff0c\u53ef\u5439\u6563\u7ec6\u80de\u514b\u9686\u56e2\u540e\u8c03\u6574\u7ec6\u80de\u5bc6\u5ea6\u81f30.5-1\u00d7106<\/sup>\/ml\uff0c\u79bb\u5fc3\u91cd\u60ac\u5728\u65b0\u9c9c\u57f9\u517b\u57fa\u4e2d\u3002<\/p>\n\n\n\n

      Q \u5982\u679c\u6211\u9700\u8981\u89c2\u5bdfT\u7ec6\u80de\u589e\u6b96\u80fd\u529b\uff0c\u6709\u54ea\u4e9b\u65b9\u6848\u5462\uff1f<\/strong><\/p>\n\n\n\n

      A<\/strong> \u53ef\u4ee5\u91c7\u7528\u7ec6\u80de\u8ba1\u6570\u7684\u65b9\u6cd5\uff0c\u4e5f\u53ef\u4ee5\u5229\u7528\u67d3\u6599\u7a00\u91ca\u6cd5\u89c2\u5bdfT\u7ec6\u80de\u7684\u589e\u6b96\u4ee3\u6570\uff0c\u63a8\u8350\u4f7f\u7528CellTrace\u7ec6\u80de\u589e\u6b96\u68c0\u6d4b\u8bd5\u5242\uff08\u4f8b\u5982Celltrace CFSE\uff0c\u8d27\u53f7C34554\uff09\uff0c\u6b64\u5916\u5229\u7528Click-it EdU\u7684\u65b9\u6cd5\u4e5f\u53ef\u4ee5\u68c0\u6d4b\u4e0d\u540c\u523a\u6fc0\u6761\u4ef6\u4e0bT\u7ec6\u80de\u7684\u589e\u6b96\u80fd\u529b\u3002<\/p>\n\n\n\n

      Q CD3\/CD28\u78c1\u73e0\u6fc0\u6d3b\u4e0eCD3\/CD28\u6297\u4f53\u6fc0\u6d3bT\u7ec6\u80de\u6709\u4ec0\u4e48\u533a\u522b\uff1f<\/strong><\/p>\n\n\n\n

      A<\/strong> \u78c1\u73e0\u63d0\u4f9b\u4e86\u591a\u4ef7\u4ea4\u8054\u4fe1\u53f7\uff0c\u901a\u5e38\u6fc0\u6d3b\u5f3a\u5ea6\u8f83\u9ad8\u4e14\u6301\u7eed\u65f6\u95f4\u8f83\u957f\uff0c\u80fd\u591f\u66f4\u6709\u6548\u5730\u6a21\u62df\u5929\u7136APC\u7684\u4f5c\u7528\uff0c\u4f46\u4ef7\u683c\u8f83\u9ad8\uff0c\u5e38\u7528\u4e8e\u9700\u8981\u9ad8\u6548\u6fc0\u6d3bT\u7ec6\u80de\u7684\u5b9e\u9a8c\uff1b\u6297\u4f53\u6fc0\u6d3b\u7684\u64cd\u4f5c\u76f8\u5bf9\u7b80\u5355\uff0c\u6fc0\u6d3b\u5f3a\u5ea6\u548c\u6301\u7eed\u65f6\u95f4\u53ef\u80fd\u76f8\u5bf9\u8f83\u5f31\uff0c\u9002\u7528\u4e8e\u4e00\u822c\u7684T\u7ec6\u80de\u6fc0\u6d3b\u5b9e\u9a8c\u3002<\/p>\n\n\n\n

      \u5176\u4ed6\u53ef\u53c2\u8003\u7684T\u7ec6\u80de\u523a\u6fc0\u6d3b\u5316\u65b9\u6cd5[3]<\/sup><\/strong><\/h2>\n\n\n\n
      \"\"<\/figure>\n\n\n\n

      *ConA\u548cPHA \u4f5c\u7528\u673a\u5236\u7c7b\u4f3c\uff0c\u4e24\u8005\u53ef\u4ee5\u7ed3\u5408\u7ec6\u80de\u819c\u86cb\u767d\u4e0a\u7684\u7cd6\u57fa\u57fa\u56e2\uff0c\u8bf1\u53d1T\u7ec6\u80de\u53d7\u4f53\u7684\u4ea4\u8054\uff0c\u4ece\u800c\u6fc0\u6d3bT\u7ec6\u80de\u3002<\/p>\n\n\n\n

      *\u8f85\u52a9\u7ec6\u80de\uff1a\u4e0eAPC\u7ec6\u80de\u529f\u80fd\u7c7b\u4f3c\uff0c\u4e3aT\u7ec6\u80de\u6fc0\u6d3b\u63d0\u4f9b\u5171\u523a\u6fc0\u5206\u5b50\u6216\u8005Fc\u53d7\u4f53\uff08\u53ef\u63d0\u4f9b\u6297\u4f53\u7ed3\u5408\u4f4d\u70b9\uff09\u3002\u7ec6\u80de\u6765\u6e90\u53ef\u4ee5\u662f\u5220\u9664\u6216\u672a\u5220\u9664T\u7ec6\u80de\u7684\u5176\u4ed6\u514d\u75ab\u7ec6\u80de\u7ec4\u5206\u3002\u4e3a\u907f\u514d\u8f85\u52a9\u7ec6\u80de\u7684\u80cc\u666f\u589e\u6b96\uff0c\u53ef\u4ee5\u7528\u7ec6\u80de\u8272\u7d20C\u6216\u8005\u03b3\u5c04\u7ebf\u8fdb\u884c\u5904\u7406\u3002<\/p>\n\n\n\n

      \u53c2\u8003\u6587\u732e\uff1a<\/h2>\n\n\n\n

      [1] K Shah, K., Al-Haidari, A., Sun, J., & Kazi, J. U. (2021). T cell receptor (TCR) signaling in health and disease. Signal transduction and targeted therapy, 6(1), 412. doi: 10.1038\/s41392-021-00823-w.<\/p>\n\n\n\n

      [2] Cappell, K. M., & Kochenderfer, J. N. (2021). A comparison of chimeric antigen receptors containing CD28 versus 4-1BB costimulatory domains. Nature reviews Clinical oncology, 18(11), 715-727. doi: 10.1038\/s41571-021-00530-z<\/p>\n\n\n\n

      [3] Kruisbeek, A. M., Shevach, E., & Thornton, A. M. (2004). Proliferative Assays for T Cell Function. Current Protocols in Immunology. doi:10.1002\/0471142735.im0312s60<\/p>\n\n\n\n

      \"contact<\/a><\/figure>\n\n\n\n

      <\/p>\n","protected":false},"excerpt":{"rendered":"

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