{"id":1836,"date":"2026-05-26T01:52:51","date_gmt":"2026-05-26T01:52:51","guid":{"rendered":"https:\/\/www.thermofisher.com\/blog\/accelerating-science-in-china\/?p=1836"},"modified":"2026-05-26T01:52:52","modified_gmt":"2026-05-26T01:52:52","slug":"olink-igan","status":"publish","type":"post","link":"https:\/\/www.thermofisher.cn\/blog\/olink-igan\/","title":{"rendered":"\u89e3\u653e\u519b\u603b\u9662\u9648\u9999\u7f8e\u9662\u58eb\u56e2\u961f\u5229\u7528Olink\u5c3f\u6db2\u86cb\u767d\u7ec4\u5b66\u65e0\u521b\u9884\u6d4b\u80be\u635f\u4f24"},"content":{"rendered":"\n

\u524d\u5f80\u8d5b\u9ed8\u98deOlink\u4e3b\u9875<\/a>><\/strong><\/p>\n\n\n\n

\u7814\u7a76\u80cc\u666f<\/strong><\/h2>\n\n\n\n

IgA\u80be\u75c5\uff08IgAN\uff09<\/strong>\u662f\u6700\u5e38\u89c1\u7684\u539f\u53d1\u6027\u80be\u5c0f\u7403\u80be\u708e\uff0c\u53ef\u5bfc\u81f4\u7ec8\u672b\u671f\u80be\u75c5\u548c\u6b7b\u4ea1\u7387\u589e\u52a0\u3002\u76ee\u524d\u5bf9\u4e8eIgAN\u6f5c\u5728\u75c5\u7406\u751f\u7406\u673a\u5236<\/strong>\u7684\u7406\u89e3\u4ecd\u4e0d\u5b8c\u6574\uff0c\u7ea630%\u81f340%\u7684\u4e2a\u4f53\u572820\u5e74\u5185\u4f1a\u53d1\u5c55\u81f3\u7ec8\u672b\u671f\u80be\u75c5\uff0c\u8fd9\u7ed9\u4e34\u5e8a\u7ba1\u7406<\/strong>\u5e26\u6765\u4e86\u5de8\u5927\u7684\u6311\u6218\u3002\u4e3a\u4e86\u6539\u5584IgAN\u60a3\u8005\u7684\u9884\u540e\uff0c\u8feb\u5207\u9700\u8981\u7cbe\u786e\u7684\u5206\u5b50\u9776\u70b9<\/strong>\u6765\u8fdb\u884c\u9884\u9632\u548c\u6cbb\u7597\u3002<\/p>\n\n\n\n

\u65b0\u6587\u901f\u9012<\/strong><\/h2>\n\n\n\n
\"\"<\/figure>\n\n\n\n

\u89e3\u653e\u519b\u603b\u533b\u9662\u9648\u9999\u7f8e\u9662\u58eb\u3001\u5f20\u654f\u6559\u6388\u56e2\u961f\u8054\u5408\u897f\u5b89\u4ea4\u901a\u5927\u5b66\u7b2c\u4e00\u9644\u5c5e\u533b\u9662\u59dc\u7ea2\u4e3d\u6559\u6388\u56e2\u961f<\/strong>\uff0c\u8fd1\u671f\u5728\u56fd\u9645\u6742\u5fd7MedComm <\/em>\uff08IF=10.57\uff09\u53d1\u8868\u4e86\u9898\u4e3a\u201cAn inflammatory cytokine signature predicts IgA nephropathy severity and progression\u201d\u7684\u7814\u7a76\u8bba\u6587\uff1a\u7814\u7a76\u901a\u8fc7\u6574\u5408\u591a\u7ec4\u5b66\u6570\u636e<\/strong>\uff0c\u786e\u5b9a\u4e86\u4e0eIgAN\u8fdb\u5c55\u76f8\u5173\u7684\u7279\u5b9a\u5206\u5b50\u7279\u5f81<\/strong>\u548c\u4fe1\u53f7\u901a\u8def\uff0c\u5e76\u53d1\u73b0\u4e86\u53ef\u9884\u6d4bIgAN \u8fdb\u5c55\u7684\u65e0\u521b\u5c3f\u6db2\u86cb\u767d\u751f\u7269\u6807\u5fd7\u7269<\/strong>\u3002<\/p>\n\n\n\n

\u7814\u7a76\u4eae\u70b9<\/strong><\/h2>\n\n\n\n

\u901a\u8fc7\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u6d4b\u5e8f\u9274\u5b9aIgAN\u7ec6\u80de\u7c7b\u578b<\/strong><\/p>\n\n\n\n

\u901a\u8fc7\u5206\u6790 IgAN \u548c\u5065\u5eb7\u5bf9\u7167\uff08HC\uff09\u7ec4\u7ec7\u6837\u672c\u7684 scRNA-seq \u6570\u636e\uff0c\u9274\u5b9a\u51fa 13 \u79cd\u4e3b\u8981\u7ec6\u80de\u4e9a\u578b<\/strong>\uff0c\u5305\u62ec\u80be\u5c0f\u7403\u5185\u76ae\u7ec6\u80de\uff08Endo\uff09\u3001\u95f4\u5145\u8d28\u7ec6\u80de\uff08Mes\uff09\u3001\u8db3\u7ec6\u80de\uff08Podo\uff09\u3001\u80be\u5c0f\u7ba1\u4e0a\u76ae\u7ec6\u80de\uff08TECs\uff09\u3001\u53d7\u635f\u548c\u708e\u6027 TEC\uff08iTEC\uff09\u7b49\u3002IgAN \u60a3\u8005\u4e2d Endo\u3001Mes\u3001iTEC \u548c\u767d\u7ec6\u80de\uff08Leu\uff09\u7684\u6bd4\u4f8b\u5347\u9ad8\uff0c\u800c Podo\u3001\u6b63\u5e38 TEC \u548c\u8fdc\u7aef\u80be\u5c0f\u7ba1\u7ec6\u80de\uff08DT\uff09\u51cf\u5c11\u3002\u7ec6\u80de\u901a\u8def\u5bcc\u96c6\u548c\u5dee\u5f02\u8868\u8fbe\u57fa\u56e0<\/strong>\u5206\u6790\u663e\u793a\uff0cIgAN \u60a3\u8005\u7684\u7ea4\u7ef4\u5316\u6807\u5fd7\u7269\u3001\u708e\u75c7\u6807\u5fd7\u7269\u3001TNF\u03b1 \u4fe1\u53f7\u901a\u8def\u76f8\u5173\u57fa\u56e0\u4ee5\u53ca\u5e72\u6270\u7d20\u5bb6\u65cf\u57fa\u56e0\u7684\u8868\u8fbe\u6c34\u5e73\u9ad8\u4e8e HC\u3002\u53e6\u5916\uff0c\u6f5c\u5728\u7684\u708e\u75c7\u914d\u4f53-\u53d7\u4f53<\/strong>\u76f8\u4e92\u4f5c\u7528\u4e5f\u53c2\u4e0e\u4e86 IgAN \u7684\u514d\u75ab\u635f\u4f24\u3002<\/p>\n\n\n\n

\u5c3f\u6db2\u4e2dIgAN\u8fdb\u5c55\u76f8\u5173\u86cb\u767d\u6807\u5fd7\u7269\u9274\u5b9a<\/strong><\/p>\n\n\n\n

    \n
  • \u5c3f\u6db2\u86cb\u767d\u68c0\u6d4b\u4e0e\u6837\u672c\u7279\u5f81\uff1a<\/strong><\/li>\n<\/ul>\n\n\n\n

    \u91c7\u7528 Olink \u86cb\u767d\u7ec4\u5b66<\/strong>\u6280\u672f\uff0c\u68c0\u6d4b\u4e86 32 \u4f8b HC\u300157 \u4f8b\u7a33\u5b9a\u578b IgAN \u548c 63 \u4f8b\u8fdb\u5c55\u578b IgAN \u60a3\u8005\u7684\u5c3f\u6db2\u86cb\u767d\u5dee\u5f02<\/strong>\u3002\u53d1\u73b0\u8fdb\u5c55\u578b IgAN \u60a3\u8005\u7684 24 \u5c0f\u65f6\u5c3f\u86cb\u767d\u3001\u767d\u86cb\u767d \/ \u808c\u9150\u6bd4\u503c\uff08ACR\uff09\u548c\u6162\u6027\u80be\u810f\u75c5\uff08CKD\uff09\u5206\u671f\u8f83\u9ad8\uff0c\u800c\u968f\u8bbf\u65f6\u7684 eGFR \u503c\u8f83\u4f4e\u3002<\/p>\n\n\n\n

      \n
    • \u86cb\u767d\u5171\u8868\u8fbe\u7f51\u7edc\u4e0e\u5dee\u5f02\u8868\u8fbe\u86cb\u767d\uff1a<\/strong><\/li>\n<\/ul>\n\n\n\n

      \u63a5\u4e0b\u6765\uff0c\u9488\u5bf9 88 \u79cd\u514d\u75ab\u53cd\u5e94<\/strong>\u548c 92\u79cd\u708e\u6027\u5c3f\u6db2\u86cb\u767d<\/strong>\u8fdb\u884c\u76f8\u5173\u6027\u7f51\u7edc\u5206\u6790\uff0c\u786e\u5b9a\u4e86\u4e94\u4e2a\u72ec\u7279\u7684\u5c3f\u6db2\u8868\u8fbe\u6a21\u5757<\/strong>\u3002\u6a21\u5757 5 \u5305\u542b 22 \u79cd<\/strong>\u4e0a\u8c03\u86cb\u767d\uff08\u5982 TWEAK\u3001CXCL1\u3001MCP1\u3001TRAIL\u3001CXCL9\u3001CXCL10\u3001IL10\u3001IL18 \u548c CXCL12\uff09\uff0c\u6d89\u53ca\u7ec6\u80de\u56e0\u5b50-\u7ec6\u80de\u56e0\u5b50\u53d7\u4f53\u76f8\u4e92\u4f5c\u7528\u3001\u4fc3\u708e\u548c\u4fc3\u7ea4\u7ef4\u5316\u901a\u8def\u3001IL-17 \u4fe1\u53f7\u901a\u8def\u4ee5\u53ca\u4ecb\u5bfc\u975e\u7ecf\u5178 NF-\u03baB \u901a\u8def\u7684 TNF \u53d7\u4f53\u8d85\u5bb6\u65cf\u6210\u5458\u3002\u5728 180 \u79cd<\/strong>\u88ab\u68c0\u6d4b\u7684\u5c3f\u6db2\u86cb\u767d\u4e2d\uff0c22 \u79cd<\/strong>\u5728 IgAN \u4e2d\u8f83 HC \u4e0a\u8c03\uff0c19 \u79cd<\/strong>\u5728\u8fdb\u5c55\u578b IgAN \u4e2d\u8f83\u7a33\u5b9a\u578b IgAN \u4e0a\u8c03\uff0c\u5176\u4e2d 7 \u79cd<\/strong>\u86cb\u767d\uff08\u5305\u62ec TWEAK\u3001CXCL1\u3001MCP1\u3001TRAIL \u548c CXCL12\uff09\u5728 IgAN \u4e2d\u663e\u8457\u4e0a\u8c03\uff0c\u4e14\u5728\u8fdb\u5c55\u578b IgAN \u4e2d\u8868\u8fbe\u6c34\u5e73\u66f4\u9ad8\u3002\u8fd9\u4e9b\u708e\u75c7\u7ec6\u80de\u56e0\u5b50\u4e0e\u968f\u8bbf\u65f6\u7684 eGFR \u503c\u5448\u663e\u8457\u8d1f\u76f8\u5173\uff0c\u4e0e ACR \u548c 24 \u5c0f\u65f6\u5c3f\u86cb\u767d\u5448\u663e\u8457\u6b63\u76f8\u5173\u3002\u516c\u5171\u6570\u636e\u96c6\u5206\u6790\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u4e86 CXCL12\u3001CCL2\uff08MCP1\uff09\u548c CXCL1 \u7684\u8868\u8fbe\u4e0e eGFR \u503c\u548c\u5c3f\u86cb\u767d\u6307\u6807\u7684\u76f8\u5173\u6027\u3002\u80be\u5b58\u6d3b\u7814\u7a76\u8868\u660e\uff0c\u8fd9\u4e9b\u86cb\u767d\u8868\u8fbe\u6c34\u5e73\u8f83\u9ad8<\/strong>\u7684 IgAN \u60a3\u8005\u9884\u540e\u8f83\u5dee\u3002<\/p>\n\n\n\n

        \n
      • \u5c3f\u6db2\u708e\u75c7\u86cb\u767d\u4e0e IgAN \u4e25\u91cd\u7a0b\u5ea6\u76f8\u5173\u6027\uff1a<\/strong><\/li>\n<\/ul>\n\n\n\n

        \u5c3f\u6db2\u708e\u75c7\u86cb\u767d<\/strong> TWEAK\u3001CXCL1\u3001MCP1\u3001TRAIL \u548c CXCL12 \u4e0e CKD \u5206\u671f\u3001ACR \u503c\u300124 \u5c0f\u65f6\u5c3f\u86cb\u767d<\/strong>\u548c\u725b\u6d25T\u8bc4\u5206\u7b49\u4e34\u5e8a\u6307\u6807\u5bc6\u5207\u76f8\u5173\u3002CXCL1\u3001TWEAK \u548c CXCL12 \u5728\u4e25\u91cd CKD \u5206\u671f\u3001\u725b\u6d25T\u8bc4\u5206\u8f83\u9ad8\u548c\u6709\u6bdb\u7ec6\u8840\u7ba1\u5916\u589e\u751f\uff08Ep\uff09\u75c5\u53d8\u7684\u60a3\u8005\u4e2d\u8868\u8fbe\u66f4\u9ad8\uff0c\u800c\u4e0d\u540c\u725b\u6d25M \u548c S\u8bc4\u5206\u7684\u60a3\u8005\u4e2d\u8fd9\u4e9b\u86cb\u767d\u6c34\u5e73\u76f8\u4f3c\u3002<\/p>\n\n\n\n

        \"\"<\/figure>\n\n\n\n

        IgAN\u8fdb\u5c55\u9884\u6d4b\u56e0\u7d20\u7b5b\u9009<\/strong><\/p>\n\n\n\n

          \n
        • \u5355\u53d8\u91cf\u548c\u591a\u53d8\u91cf\u56de\u5f52\u5206\u6790\uff1a<\/strong><\/li>\n<\/ul>\n\n\n\n

          \u5355\u53d8\u91cf\u903b\u8f91\u56de\u5f52\u5206\u6790\u8868\u660e\uff0cTWEAK\u3001CXCL1\u3001MCP1\u3001TRAIL \u548c CXCL12 \u662f IgAN \u8fdb\u5c55\u7684\u6f5c\u5728\u9884\u6d4b\u56e0\u5b50<\/strong>\u3002\u591a\u53d8\u91cf\u8c03\u6574\u540e\uff0c\u53d1\u73b0\u5c3f\u6db2 MCP1 \u548c CXCL12 \u6c34\u5e73\u4e0e IgAN \u8fdb\u5c55\u7684\u4e25\u91cd\u7a0b\u5ea6\u5bc6\u5207\u76f8\u5173\u3002\u5728\u4e34\u5e8a\u6307\u6807\u4e2d\uff0c\u725b\u6d25\u5206\u7c7bT\u75c5\u53d8\u548c Ep\u75c5\u53d8\u662f\u9884\u6d4b IgAN\u8fdb\u5c55\u7684\u6700\u91cd\u8981\u98ce\u9669\u56e0\u7d20\u3002<\/p>\n\n\n\n

            \n
          • LASSO \u56de\u5f52\u4e0e\u98ce\u9669\u6307\u6570\u6a21\u578b\uff1a<\/strong><\/li>\n<\/ul>\n\n\n\n

            LASSO \u903b\u8f91\u56de\u5f52\u5206\u6790\u663e\u793a\uff0cCXCL12<\/strong> \u548c MCP1 <\/strong>\u662f\u9884\u6d4b IgAN \u8fdb\u5c55\u7684\u91cd\u8981\u5c3f\u6db2\u86cb\u767d\u751f\u7269\u6807\u5fd7\u7269<\/strong>\u3002\u57fa\u4e8e\u4e34\u5e8a\u6307\u6807\uff0824 \u5c0f\u65f6\u5c3f\u86cb\u767d\u8868\u8fbe\u3001\u5e74\u9f84\u3001\u6027\u522b\u3001eGFR\u3001\u725b\u6d25\u5206\u7c7bMEST \u548c Ep \u75c5\u53d8\uff09\u5efa\u7acb\u57fa\u7840\u6a21\u578b\uff0c\u5e76\u7ed3\u5408 CXCL12\u3001MCP1 \u6784\u5efa\u98ce\u9669\u6307\u6570\u6a21\u578b\uff0c\u8be5\u6a21\u578b\u5728\u9884\u6d4b IgAN \u8fdb\u5c55\u65b9\u9762\u8868\u73b0\u6700\u4f73\uff0cAUC \u4e3a 0.896<\/strong>\u3002\u98ce\u9669\u6307\u6570\u6a21\u578b\u8bc4\u5206\u4e0e IgAN \u7684\u4e0d\u826f\u9884\u540e\u76f8\u5173\u3002<\/p>\n\n\n\n

            \"\"<\/figure>\n\n\n\n

            \u5199\u5728\u6700\u540e<\/strong><\/h2>\n\n\n\n

            \u7814\u7a76\u56e2\u961f\u901a\u8fc7\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u6d4b\u5e8f\u7ed3\u5408Olink\u5c3f\u6db2\u86cb\u767d\u7ec4\u5b66\u5206\u6790<\/strong>\uff0c\u7814\u7a76\u4eba\u5458\u786e\u5b9a\u4e86\u4e0eIgAN\u76f8\u5173\u7684\u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u6027\u7279\u5f81\u57fa\u56e0<\/strong>\u3001\u901a\u8def\u548c\u914d\u4f53-\u53d7\u4f53\u5bf9\uff0c\u53d1\u73b0\u4e86\u5c3f\u6db2\u4e2d CXCL1\u3001TWEAK\u3001TRAIL\u3001MCP1 \u548c CXCL12 \u7b49\u708e\u6027\u86cb\u767d<\/strong>\u53ef\u4f5c\u4e3a IgAN \u8fdb\u5c55\u7684\u9884\u6d4b\u56e0\u5b50<\/strong>\u3002\u8fd9\u4e9b\u53d1\u73b0\u4e3a IgAN \u7684\u9884\u540e\u8bc4\u4f30\u548c\u4e34\u5e8a\u51b3\u7b56\u63d0\u4f9b\u4e86\u6f5c\u5728\u7684\u751f\u7269\u6807\u5fd7\u7269<\/strong>\uff0c\u5e76\u4e3a\u5f00\u53d1\u65e0\u521b\u8bc4\u4f30 IgAN \u8fdb\u5c55\u7a0b\u5ea6\u7684\u65b9\u6cd5\u63d0\u4f9b\u4e86\u4f9d\u636e\u3002\u672a\u6765\u7814\u7a76\u9700\u8981\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u8fd9\u4e9b\u86cb\u767d\u662f\u5426\u4e3a IgAN \u7279\u5f02\u6027\u751f\u7269\u6807\u5fd7\u7269\uff0c\u5e76\u6269\u5927\u6837\u672c\u91cf<\/strong>\u4ee5\u63d0\u9ad8\u7ed3\u679c\u7684\u53ef\u9760\u6027\u3002<\/p>\n\n\n\n

            \u53c2\u8003\u8d44\u6599<\/strong><\/p>\n\n\n\n

            1. Chen L, Chen X, Cai G, Jiang H, Chen X, Zhang M. An inflammatory cytokine signature predicts IgA nephropathy severity and progression. MedComm. 2024;e783. https:\/\/doi.org\/10.1002\/mco2.783<\/p>\n\n\n\n

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