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\"\"<\/figure>\n\n\n\n

\u5927\u89c4\u6a21\u7814\u7a76\u89e3\u7801\u8840\u6db2\u86cb\u767d\u4e0e\u764c\u75c7\u5173\u8054<\/strong><\/h2>\n\n\n\n

\u7814\u7a76\u8bbe\u8ba1\u4e0e\u65b9\u6cd5\u5b66<\/strong><\/p>\n\n\n\n

\u7814\u7a76\u4e25\u683c\u9075\u5faaPRISMA\uff08\u7cfb\u7edf\u7efc\u8ff0\u548c\u835f\u8403\u5206\u6790\u4f18\u5148\u62a5\u544a\u6761\u76ee<\/strong>\uff09\u6307\u5357\uff0c\u7814\u7a76\u56e2\u961f\u68c0\u7d22\u4e86Embase\u548cMedline\u6570\u636e\u5e93\u622a\u81f32023\u5e7412\u6708\u7684\u76f8\u5173\u6587\u732e\uff0c\u5e76\u901a\u8fc7\u624b\u5de5\u68c0\u7d22\u8865\u5145\u81f32024\u5e746\u6708\uff0c\u6700\u7ec8\u7eb3\u5165\u7b26\u5408\u4ee5\u4e0b\u6807\u51c6\u7684\u7814\u7a76\uff1a\u91c7\u7528\u591a\u91cd\u86cb\u767d\u8d28\u68c0\u6d4b\u6280\u672f\u3001\u7814\u7a76\u5bf9\u8c61\u4e3a\u57fa\u7ebf\u65e0\u764c\u75c7\u8bca\u65ad\u7684\u6210\u5e74\u4eba\u3001\u660e\u786e\u62a5\u544a\u57fa\u7ebf\u5faa\u73af\u86cb\u767d\u6c34\u5e73\u4e0e\u65b0\u53d1\u764c\u75c7\u98ce\u9669\u7684\u5173\u8054\u3002\u7814\u7a76\u805a\u712610\u79cd\u764c\u75c7\uff1a\u98df\u7ba1\u764c\u3001\u80c3\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u3001\u809d\u764c\u3001\u80ba\u764c\u3001\u4e73\u817a\u764c\u3001\u5b50\u5bab\u9888\u764c\u3001\u524d\u5217\u817a\u764c\uff0c\u8180\u80f1\u764c\u548c\u7532\u72b6\u817a\u764c\u3002<\/p>\n\n\n\n

\u91c7\u7528\u56fa\u5b9a\u6548\u5e94\u835f\u8403\u5206\u6790\u5408\u5e76\u591a\u9879\u7814\u7a76\u4e2d\u5faa\u73af\u86cb\u767d\u4e0e\u764c\u75c7\u98ce\u9669\u7684\u6548\u5e94\u91cf\uff0c\u7ecf\u5047\u53d1\u73b0\u7387\uff08FDR\uff09\u6821\u6b63\u540e\uff0c\u5bf9\u663e\u8457\u5173\u8054\u7684\u86cb\u767d\u8fdb\u4e00\u6b65\u901a\u8fc7\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u3001\u5916\u663e\u5b50\u86cb\u767d\u8bc4\u5206\u7b49\u9057\u4f20\u5b66\u5206\u6790\uff0c\u9a8c\u8bc1\u5176\u5728\u764c\u75c7\u75c5\u56e0\u5b66\u4e2d\u7684\u4f5c\u7528\uff0c\u63d0\u5347\u7ed3\u8bba\u7684\u56e0\u679c\u63a8\u65ad\u5f3a\u5ea6\u3002\u7814\u7a76\u4eba\u7fa4\u4e0e\u6838\u5fc3\u6570\u636e<\/strong><\/p>\n\n\n\n

26\u9879\u7814\u7a76\u5171\u5305\u542b84,129\u540d\u57fa\u7ebf\u65e0\u764c\u53c2\u4e0e\u8005\uff0c14,326\u4eba\u5728\u968f\u8bbf\u671f\u95f4\uff081.6-12\u5e74\uff09\u786e\u8bca\u764c\u75c7\u3002\u7814\u7a76\u4e2d\u91c7\u7528\u4e86Luminex\u3001Olink\uff0c\u8d28\u8c31\u7b49\u591a\u91cd\u86cb\u767d\u68c0\u6d4b\u6280\u672f\uff0c\u8986\u76d6\u4e862,434\u79cd\u72ec\u7279\u7684\u86cb\u767d\u8d28\uff0c\u6db5\u76d619,137\u4e2a\u86cb\u767d\u8d28-\u764c\u75c7\u5173\u8054\u5206\u6790\u3002<\/p>\n\n\n\n

\u53c2\u4e0e\u8005\u4e3b\u8981\u5206\u5e03\u4e8e\u5317\u7f8e\uff0811 \u9879\u7814\u7a76\uff09\u3001\u4e9a\u6d32\uff0810 \u9879\u7814\u7a76\uff09\u548c\u6b27\u6d32\uff088 \u9879\u7814\u7a76\uff09\uff0c\u4eba\u7fa4\u7279\u5f81\u663e\u793a\uff0c\u767d\u4eba\u53c2\u4e0e\u8005\u5360\u6bd4 85.3%\uff0c\u4e9a\u6d32\u4eba\u5360 6.7%\uff0c\u9ed1\u4eba\u3001\u897f\u73ed\u7259\u88d4\u7b49\u5176\u4ed6\u65cf\u88d4\u5360\u6bd4\u4e0d\u8db3 8%\uff1b\u6027\u522b\u5206\u5e03\u76f8\u5bf9\u5747\u8861\uff0c\u5973\u6027\u5360 54.9%\uff0c\u7537\u6027\u5360 45.1%\uff1b\u57fa\u7ebf\u4e2d\u4f4d\u5e74\u9f84\u4ecb\u4e8e 47.1-66.4 \u5c81\u4e4b\u95f4\uff0c\u8986\u76d6\u4e2d\u8001\u5e74\u6838\u5fc3\u98ce\u9669\u4eba\u7fa4\u3002<\/p>\n\n\n\n

\u7814\u7a76\u56e2\u961f\u5171\u5f00\u5c55\u4e863,448\u6b21\u835f\u8403\u5206\u6790\uff0c\u7ecfFDR\u6821\u6b63\u540e\u786e\u5b9a\u4e86216\u4e2a\u663e\u8457\u7684\u86cb\u767d\u8d28-\u764c\u75c7\u5173\u8054\uff0c\u5176\u4e2d131\u4e2a\u4e3a\u672a\u88ab\u5148\u524d\u7814\u7a76\u62a5\u9053\u7684\u65b0\u578b\u5173\u8054\uff0c\u4e3b\u8981\u96c6\u4e2d\u4e8e\u80c3\u764c\uff082 \u4e2a\uff09\u3001\u7ed3\u76f4\u80a0\u764c\uff0827 \u4e2a\uff09\u3001\u80ba\u764c\uff08172 \u4e2a\uff09\u3001\u4e73\u817a\u764c\uff0814 \u4e2a\uff09\u548c\u524d\u5217\u817a\u764c\uff081 \u4e2a\uff09\uff0c\u8180\u80f1\u764c\u672a\u53d1\u73b0\u663e\u8457\u5173\u8054\u3002\u98df\u7ba1\u764c\u3001\u809d\u764c\u3001\u5bab\u9888\u764c\u548c\u7532\u72b6\u817a\u764c\u56e0\u76f8\u5173\u7814\u7a76\u6570\u636e\u4e0d\u8db3\uff0c\u672a\u80fd\u5f00\u5c55\u835f\u8403\u5206\u6790\u3002<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

\u7814\u7a76\u961f\u5217\u548c\u53c2\u4e0e\u8005\u7279\u5f81<\/p>\n\n\n\n

\u8fd9\u4e9b\u86cb\u767d\u53ef\u80fd\u662f\u764c\u75c7\u7684\u9884\u8b66\u4fe1\u53f7<\/strong><\/h2>\n\n\n\n

\u80ba\u764c\u76f8\u5173\u86cb\u767d\u6807\u5fd7\u7269<\/strong><\/p>\n\n\n\n

\u80ba\u764c\u662f\u5173\u8054\u86cb\u767d\u8d28\u6570\u91cf\u6700\u591a\u7684\u764c\u75c7\u7c7b\u578b<\/strong>\uff0c\u5171\u8bc6\u522b\u51fa172\u4e2a\u663e\u8457\u5173\u8054\u86cb\u767d\u3002\u5176\u4e2d\uff0cCEACAM5\uff08\u76f8\u5bf9\u98ce\u9669 RR=1.58\uff09\u3001WFDC2\uff08RR=1.62\uff09\u3001CXCL17\uff08RR=1.68\uff09\u8868\u73b0\u51fa\u6700\u5f3a\u7684\u9633\u6027\u5173\u8054\u3002CEACAM5<\/strong>\u4f5c\u4e3a\u4e00\u79cd\u7ec6\u80de\u8868\u9762\u7cd6\u86cb\u767d\uff0c\u5df2\u88ab\u591a\u9879\u7814\u7a76\u8bc1\u5b9e\u4e0e\u80bf\u7624\u53d1\u751f\u548c\u8f6c\u79fb\u76f8\u5173\uff0c\u5176\u5728\u8840\u6db2\u4e2d\u7684\u9ad8\u6c34\u5e73\u53ef\u80fd\u63d0\u793a\u80ba\u90e8\u7ec6\u80de\u5f02\u5e38\u589e\u6b96\u3002<\/p>\n\n\n\n

\u7814\u7a76\u540c\u65f6\u53d1\u73b0\uff0cTNR\u3001SCF\u548cGDF8\u7b4932\u79cd\u86cb\u767d\u8d28\u4e0e\u80ba\u764c\u98ce\u9669\u964d\u4f4e\u76f8\u5173\uff0c\u5176\u4e2dITGA11<\/strong>\u7684\u4fdd\u62a4\u4f5c\u7528\u5c24\u4e3a\u7a81\u51fa\uff0c\u5176\u6c34\u5e73\u5347\u9ad8\u4e0e\u80ba\u764c\u98ce\u9669\u663e\u8457\u964d\u4f4e\u76f8\u5173\uff0c\u4e14\u5f97\u5230\u4e86\u9057\u4f20\u5b66\u8bc1\u636e\u652f\u6301\u3002<\/p>\n\n\n\n

\u4e73\u817a\u764c\u4e0e\u524d\u5217\u817a\u764c\u76f8\u5173\u6807\u5fd7\u7269<\/strong><\/p>\n\n\n\n

STC2\uff08RR=1.29\uff09\u3001CRLF1\uff08RR=1.27\uff09\u548c AREG\uff08RR=1.22\uff09\u4e0e\u4e73\u817a\u764c\u98ce\u9669\u589e\u52a0\u76f8\u5173\u3002\u5176\u4e2d\uff0cSTC2<\/strong>\u4f5c\u4e3a\u7ec6\u80de\u589e\u6b96\u4e0e\u8f6c\u79fb\u8c03\u63a7\u901a\u8def\u7684\u5173\u952e\u5206\u5b50\uff0c\u5df2\u88ab\u8bc1\u5b9e\u53c2\u4e0e\u4e73\u817a\u764c\u7684\u53d1\u751f\u53d1\u5c55\uff0c\u662f\u6f5c\u5728\u7684\u6cbb\u7597\u9776\u70b9\u3002\u6b64\u5916\uff0cSIGLEC9\uff08RR=0.89\uff09\u3001ICAM2\uff08RR=0.90\uff09\u7b49\u86cb\u767d\u8d28\u4e0e\u4e73\u817a\u764c\u98ce\u9669\u964d\u4f4e\u76f8\u5173\uff0c\u4e3a\u7cbe\u51c6\u9884\u9632\u7b56\u7565\u7684\u5f00\u53d1\u63d0\u4f9b\u4e86\u65b0\u65b9\u5411\u3002<\/p>\n\n\n\n

\u524d\u5217\u817a\u764c\u65b9\u9762\uff0c\u751f\u957f\u56e0\u5b50REG1A<\/strong>\uff08RR=0.91\uff09\u88ab\u9996\u6b21\u53d1\u73b0\u4e0e\u98ce\u9669\u964d\u4f4e\u76f8\u5173\uff0c\u8be5\u53d1\u73b0\u4e3a\u524d\u5217\u817a\u764c\u7684\u4fdd\u62a4\u673a\u5236\u7814\u7a76\u4e0e\u65e9\u671f\u9884\u8b66\u6807\u5fd7\u7269\u5f00\u53d1\u63d0\u4f9b\u4e86\u5168\u65b0\u7ebf\u7d22\u3002<\/p>\n\n\n\n

\u8de8\u764c\u79cd\u86cb\u767d\u6807\u5fd7\u7269<\/strong><\/p>\n\n\n\n

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\"\"<\/figure>\n\n\n\n

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\"\"<\/figure>\n\n\n\n

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1. The circulating proteome and cancer risk: a systematic literature review and meta-analysis of 26 prospective studies with genetic validation. Dillman, Alison et al. eBioMedicine, Volume 124, 106117<\/p>\n\n\n\n

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