{"id":349,"date":"2026-02-25T02:20:08","date_gmt":"2026-02-25T02:20:08","guid":{"rendered":"https:\/\/www.thermofisher.com\/blog\/accelerating-science-in-china\/?p=349"},"modified":"2026-03-10T06:56:31","modified_gmt":"2026-03-10T06:56:31","slug":"aav-vs-lv","status":"publish","type":"post","link":"https:\/\/www.thermofisher.cn\/blog\/aav-vs-lv\/","title":{"rendered":"AAV\u4e0eLV\u6162\u75c5\u6bd2\u8f7d\u4f53"},"content":{"rendered":"
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\"\"<\/figure>\n<\/div>\n\n\n

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\n
\"Comparison
\u88681. AAV\u4e0eLV\u8f7d\u4f53\u7684\u6bd4\u8f83<\/figcaption><\/figure>\n<\/div>\n\n\n

\u5728\u7ed3\u6784\u4e0a\uff0c\u6162\u75c5\u6bd2\u8f7d\u4f53\u4ee5HIV-1\u4e3a\u57fa\u7840\uff0c\u5728\u6574\u4f53\u5927\u5c0f\u3001\u7ec4\u6210\u548c\u529f\u80fd\u65b9\u9762\u4e0e\u91ce\u751f\u578b\u75c5\u6bd2\u5177\u6709\u5171\u540c\u7279\u5f81\u300220<\/sup>\u4e0eHIV\u7c7b\u4f3c\uff0c\u6162\u75c5\u6bd2\u8f7d\u4f53\u542b\u6709RNA\u57fa\u56e0\u7ec4\uff0c\u5728\u8fdb\u5165\u88ab\u8f6c\u5bfc\u7ec6\u80de\u540e\u4f1a\u9006\u8f6c\u5f55\u4e3aDNA\u3002\u57fa\u4e8e\u6162\u75c5\u6bd2\u7684\u57fa\u56e0\u9012\u9001\u9700\u8981\u7ec6\u80de\u8868\u9762\u7ed3\u5408\u5e76\u968f\u540e\u5185\u5316\u5230\u5bbf\u4e3b\u7ec6\u80de\u4e2d\u3002\u8fd9\u4e00\u611f\u67d3\u5468\u671f\u7531\u6162\u75c5\u6bd2\u4e0e\u5bbf\u4e3b\u7ec6\u80de\u7ed3\u5408\u542f\u52a8\uff0c\u8fd9\u4e00\u8fc7\u7a0b\u9ad8\u5ea6\u4f9d\u8d56\u4e8e\u75c5\u6bd2\u5305\u819c\u7cd6\u86cb\u767d\u3002\u7531\u4e8e\u91ce\u751f\u578bHIV\u7684\u8d8b\u5411\u6027\u6709\u9650\uff0c\u5bfc\u81f4\u7ec6\u80de\u8f6c\u5bfc\u6548\u7387\u8f83\u4f4e\uff0c\u56e0\u6b64\u91cd\u7ec4\u6162\u75c5\u6bd2\uff08rLVs\uff09\u901a\u8fc7\u66ff\u6362\u5176\u4ed6\u75c5\u6bd2\u7684\u5305\u819c\u8fdb\u884c\u4f2a\u578b\u5316\uff0c\u4ee5\u589e\u5f3a\u5176\u8f6c\u5bfc\u80fd\u529b\u3002\u5176\u4e2d\u6700\u5e38\u7528\u7684\u4f2a\u578b\u662f\u6c34\u6ce1\u6027\u53e3\u708e\u75c5\u6bd2\uff08VSV G\uff09\uff0c\u4f46\u4e5f\u63a2\u7d22\u4e86\u5176\u4ed6\u7c7b\u578b\u300221<\/sup><\/p>\n\n\n\n

\u81ea\u4ecerLV\u4f5c\u4e3a\u9006\u8f6c\u5f55\u75c5\u6bd2\u8f7d\u4f53\u7684\u53ef\u884c\u66ff\u4ee3\u65b9\u6848\u51fa\u73b0\u4ee5\u6765\uff0c\u6211\u4eec\u5bf9rLV\u751f\u7269\u5b66\u7684\u7406\u89e3\u4ee5\u53ca\u5176\u72ec\u7279\u4f18\u52bf\u90fd\u6709\u4e86\u663e\u8457\u8fdb\u5c55\u3002\u4e0e\u9006\u8f6c\u5f55\u75c5\u6bd2\u8f7d\u4f53\u524d\u8eab\u4e0d\u540c\uff0crLV\u80fd\u591f\u9ad8\u6548\u8f6c\u5bfc\u9759\u6b62\u6216\u975e\u5206\u88c2\u7ec6\u80de\u300222<\/sup>\u6b64\u5916\uff0c\u7531\u4e8e\u5176\u4f18\u5148\u6574\u5408\u4f4d\u70b9\uff0crLV\u76f8\u6bd4\u9006\u8f6c\u5f55\u75c5\u6bd2\u524d\u8eab\u5177\u6709\u66f4\u9ad8\u7684\u5b89\u5168\u6027\u548c\u66f4\u4f4e\u7684\u63d2\u5165\u7a81\u53d8\u98ce\u9669\u3002\u7531\u4e8e\u8fd9\u4e9b\u4f18\u52bf\uff0cLV\u5df2\u88ab\u5e7f\u6cdb\u7528\u4e8e\u5355\u57fa\u56e0\u75be\u75c5\u6cbb\u7597\u548c\u9700\u8981\u5916\u6e90\u57fa\u56e0\u9012\u9001\u7684\u8fc7\u7ee7\u7ec6\u80de\u6cbb\u7597\u8bd5\u9a8c\u4e2d\u300223<\/sup>\u6b64\u5916\uff0cLV\u4e5f\u88ab\u5e7f\u6cdb\u5e94\u7528\u4e8e\u57fa\u56e0\u7f16\u8f91\u548c\u57fa\u56e0\u8868\u8fbe\u8c03\u63a7\u7b49\u7814\u7a76\u9886\u57df\u300224<\/sup><\/p>\n\n\n\n

\u8d5b\u9ed8\u98de\u4e16\u5c14\u79d1\u6280\u662f\u57fa\u56e0\u7ec4\u533b\u5b66\u65f6\u4ee3\u503c\u5f97\u4fe1\u8d56\u7684\u5408\u4f5c\u4f19\u4f34\u3002<\/strong><\/h3>\n\n\n\n

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\u8d5b\u9ed8\u98de\u4e16\u5c14\u79d1\u5b66\u901a\u8fc7\u591a\u79cd\u9014\u5f84\u53ca\u8d44\u6e90\u652f\u6301\u8fd9\u4e9b\u65b0\u578b\u57fa\u56e0\u6cbb\u7597\u5f00\u53d1\u8005\u3002\u8d5b\u9ed8\u98de\u62e5\u6709\u5e7f\u6cdb\u77e5\u8bc6\u4e0e\u4e13\u4e1a\u6280\u80fd\uff0c\u6db5\u76d6\u57fa\u56e0\u6cbb\u7597\u5f00\u53d1<\/a>\uff0c\u53ef\u901a\u8fc7\u5404\u79cd\u8d44\u6e90\u6216\u4fbf\u6377\u6280\u672f\u652f\u6301\u83b7\u5f97\u3002\u6b64\u5916\uff0c\u8d5b\u9ed8\u98de\u8fd8\u63d0\u4f9b\u5177\u6709\u6210\u672c\u6548\u76ca\u4e14\u884c\u4e1a\u9886\u5148\u7684AAV<\/a>\u548cLV<\/a>\u751f\u4ea7\u7cfb\u7edf\u3002\u8fd9\u4e9b\u7cfb\u7edf\u7b80\u5316\u4e86\u4ece\u4e34\u5e8a\u524d\u5230\u4e34\u5e8a\u751f\u4ea7\u7684\u8fc7\u6e21\uff0c\u4f18\u5316\u4e86\u5de5\u827a\u5f00\u53d1\u6d41\u7a0b\uff0c\u5e76\u4ee5\u4f18\u4e8ePEI\u8bd5\u5242\u7684\u9ad8\u4ea7\u7387\u5c06\u8d28\u7c92\u6210\u672c\u964d\u4f4e\u4e8625%\u3002\u51ed\u501f\u4e30\u5bcc\u7684\u4e13\u4e1a\u77e5\u8bc6\u548c\u81f4\u529b\u4e8e\u63d0\u5347\u75c5\u6bd2\u8f7d\u4f53\u5236\u9020\u53ef\u6269\u5c55\u6027\u4e0e\u6548\u7387\u7684\u4ea7\u54c1\u7ec4\u5408\uff0c\u8d5b\u9ed8\u98de\u4e16\u5c14\u627f\u8bfa\u4fdd\u969c\u57fa\u56e0\u7ec4\u836f\u7269\u7684\u4e34\u5e8a\u6210\u529f\u3002<\/p>\n\n\n\n

\u63a2\u7d22\u57fa\u56e0\u6cbb\u7597\u5f00\u53d1\u89e3\u51b3\u65b9\u6848<\/a> >><\/h3>\n\n\n\n

##<\/p>\n\n\n\n

\u4ec5\u4f9b\u79d1\u7814\u4f7f\u7528\u3002\u4e0d\u5f97\u7528\u4e8e\u8bca\u65ad\u7a0b\u5e8f\u3002<\/em><\/p>\n\n\n\n

\u00a9 2024 Thermo Fisher Scientific Inc. \u7248\u6743\u6240\u6709\u3002\u9664\u975e\u53e6\u6709\u8bf4\u660e\uff0c\u6240\u6709\u5546\u6807\u5747\u4e3a Thermo Fisher Scientific \u53ca\u5176\u5b50\u516c\u53f8\u7684\u8d22\u4ea7\u3002<\/em><\/p>\n\n\n\n

\"contact<\/a><\/figure>\n\n\n\n

\u53c2\u8003\u6587\u732e<\/strong><\/h3>\n\n\n\n
    \n
  1. Labb\u00e9, R. P., Vessillier, S. & Rafiq, Q. A. Lentiviral vectors for t cell engineering: Clinical applications, bioprocessing and future perspectives. Viruses<\/em> vol. 13 Preprint at https:\/\/doi.org\/10.3390\/v13081528 (2021).<\/li>\n\n\n\n
  2. Issa, S. S., Shaimardanova, A. A., Solovyeva, V. V. & Rizvanov, A. A. Various AAV Serotypes and Their Applications in Gene Therapy: An Overview. Cells<\/em> vol. 12 Preprint at https:\/\/doi.org\/10.3390\/cells12050785 (2023).<\/li>\n\n\n\n
  3. Kang, L. et al.<\/em> AAV vectors applied to the treatment of CNS disorders: Clinical status and challenges. Journal of Controlled Release<\/em> vol. 355 458\u2013473 Preprint at https:\/\/doi.org\/10.1016\/j.jconrel.2023.01.067 (2023).<\/li>\n\n\n\n
  4. Ogbonmide, T. et al.<\/em> Gene Therapy for Spinal Muscular Atrophy (SMA): A Review of Current Challenges and Safety Considerations for Onasemnogene Abeparvovec (Zolgensma). Cureus<\/em> (2023) doi:10.7759\/cureus.36197.<\/li>\n\n\n\n
  5. Parums, D. V. Editorial: First Regulatory Approvals for CRISPRCas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent b-Thalassemia. Medical Science Monitor<\/em> vol. 30 Preprint at https:\/\/doi.org\/10.12659\/MSM.944204 (2024).<\/li>\n\n\n\n
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  9. Bolt, M. W., Brady, J. T., Whiteley, L. O. & Nasir Khan, K. Development challenges associated with rAAV-based gene therapies. J. Toxicol. Sci. <\/em>46<\/strong>, 57\u201368 (2021).<\/li>\n\n\n\n
  10. Pupo, A. et al.<\/em> AAV vectors: The Rubik\u2019s cube of human gene therapy. Molecular Therapy<\/em> vol. 30 3515\u20133541 Preprint at https:\/\/doi.org\/10.1016\/j.ymthe.2022.09.015 (2022).<\/li>\n\n\n\n
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  16. Ishikawa, K., Weber, T. & Hajjar, R. J. Human cardiac gene therapy. Circulation Research<\/em> vol. 123 601\u2013613 Preprint at https:\/\/doi.org\/10.1161\/CIRCRESAHA.118.311587 (2018).<\/li>\n\n\n\n
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  18. Gutierrez\u2010Guerrero, A., Cosset, F. L. & Verhoeyen, E. Lentiviral Vector Pseudotypes: Precious Tools to Improve Gene Modification of Hematopoietic Cells for Research and Gene Therapy. Viruses<\/em> 12<\/strong>, (2020).<\/li>\n\n\n\n
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  21. Coil, D. A. & Miller, A. D. Phosphatidylserine Is Not the Cell Surface Receptor for Vesicular Stomatitis Virus. J Virol<\/em> 78<\/strong>, 10920\u201310926 (2004).<\/li>\n\n\n\n
  22. Milone, M. C. & O\u2019Doherty, U. Clinical use of lentiviral vectors. Leukemia<\/em> vol. 32 1529\u20131541 Preprint at https:\/\/doi.org\/10.1038\/s41375-018-0106-0 (2018).<\/li>\n\n\n\n
  23. Perry, C. & Rayat, A. C. M. E. Lentiviral vector bioprocessing. Viruses<\/em> 13<\/strong>, (2021).<\/li>\n\n\n\n
  24. Rittiner, J., Cumaran, M., Malhotra, S. & Kantor, B. Therapeutic modulation of gene expression in the disease state: Treatment strategies and approaches for the development of next-generation of the epigenetic drugs. Frontiers in Bioengineering and Biotechnology<\/em> vol. 10 Preprint at https:\/\/doi.org\/10.3389\/fbioe.2022.1035543 (2022).<\/li>\n\n\n\n
  25. McColl-Carboni, A. et al.<\/em> Analytical characterization of full, intermediate, and empty AAV capsids. Gene Ther<\/em> 31<\/strong>, 285\u2013294 (2024).<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

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