{"id":716,"date":"2026-03-06T08:21:43","date_gmt":"2026-03-06T08:21:43","guid":{"rendered":"https:\/\/www.thermofisher.com\/blog\/accelerating-science-in-china\/?p=716"},"modified":"2026-05-13T02:52:09","modified_gmt":"2026-05-13T02:52:09","slug":"hplc-troubleshooting-tips-why-signal-to-noise-ratio-determines","status":"publish","type":"post","link":"https:\/\/www.thermofisher.cn\/blog\/hplc-troubleshooting-tips-why-signal-to-noise-ratio-determines\/","title":{"rendered":"\u9ad8\u6548\u6db2\u76f8\u8272\u8c31(HPLC)\u6545\u969c\u6392\u67e5\uff1a\u4e3a\u4f55\u4fe1\u566a\u6bd4(SNR)\u51b3\u5b9a\u68c0\u51fa\u9650"},"content":{"rendered":"\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/www.thermofisher.cn\/cn\/zh\/home\/industrial\/chromatography\/download-solution.html?icid=cn-blog-cmd\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"176\" src=\"http:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/779-\u00d7-134-CMD-1024x176.jpg\" alt=\"\" class=\"wp-image-1799\" srcset=\"https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/779-\u00d7-134-CMD-1024x176.jpg 1024w, https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/779-\u00d7-134-CMD-300x52.jpg 300w, https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/779-\u00d7-134-CMD-768x132.jpg 768w, https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/779-\u00d7-134-CMD-1536x264.jpg 1536w, https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/779-\u00d7-134-CMD-2048x352.jpg 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure>\n\n\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignright\"><img decoding=\"async\" src=\"http:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2023\/06\/052522-HPLC-Troubleshooting-1.jpg\" alt=\"\" class=\"wp-image-13204\" \/><\/figure>\n<\/div>\n\n\n<p>\u5728\u6211\u7684\u65e5\u5e38\u5de5\u4f5c\u4e2d\uff0c\u68c0\u6d4b\u5668\u7684\u8bbe\u7f6e\u548c\u53c2\u6570\u8d8a\u6765\u8d8a\u5f97\u4e0d\u5230\u8db3\u591f\u7684\u5173\u6ce8\u548c\u91cd\u89c6\u3002<\/p>\n\n\n\n<p>\u4f46\u5728\u544a\u8bc9\u4f60\u5173\u4e8e\u6b63\u786e\u6570\u636e\u901f\u7387\u53ca\u76f8\u5173\u65f6\u95f4\u5e38\u6570\u8bbe\u7f6e\u7684\u6700\u4f73\u5b9e\u8df5\uff0c\u6216\u8005\u7d2b\u5916\u68c0\u6d4b\u5668\u72ed\u7f1d\u5bbd\u5ea6\u8bbe\u7f6e\u5982\u4f55\u5f71\u54cd\u8272\u8c31\u7ed3\u679c\u4e4b\u524d\uff0c\u6211\u60f3\u5148\u5f3a\u8c03\u4e00\u4e2a\u7406\u8bba\u4e0a\u4e0d\u592a\u590d\u6742\u7684\u8bdd\u9898\uff1a<strong>\u4fe1\u566a\u6bd4\uff08SNR\uff09<\/strong>.<\/p>\n\n\n\n<p>\u539f\u56e0\u5f88\u7b80\u5355\uff0cSNR\u662f\u89e3\u91ca\u5927\u591a\u6570\u4e0e\u68c0\u6d4b\u5668\u76f8\u5173\u7684\u5173\u8054\u6216\u76f8\u4e92\u5173\u7cfb\u7684\u5173\u952e\u3002\u5173\u4e8e\u68c0\u6d4b\u5668\u8bbe\u7f6e\u7684\u6700\u4f73\u5b9e\u8df5\uff0c\u5728\u5176\u4ed6\u591a\u79cd\u8d44\u6599\u4e2d\u5df2\u6709\u5145\u5206\u63cf\u8ff0\u3002\u4f60\u53ea\u9700\u67e5\u9605\u76f8\u5e94\u7684\u68c0\u6d4b\u5668\u624b\u518c\uff0c\u4f7f\u7528<a href=\"https:\/\/www.thermofisher.cn\/cn\/zh\/home\/industrial\/chromatography\/chromatography-data-systems-cds.html\" target=\"_blank\" rel=\"noreferrer noopener\">Thermo Scientific\u2122 Chromeleon\u2122 \u8272\u8c31\u6570\u636e\u7cfb\u7edf<\/a>(CDS)\u4e2d\u7684\u68c0\u6d4b\u5668\u5411\u5bfc\u6216\u5e2e\u52a9\u529f\u80fd\uff0c\u6216\u8005\u5728\u7f51\u4e0a\u641c\u7d22\u5373\u53ef\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"toc-hId-1154323672\"><strong><strong>\u4e3a\u4ec0\u4e48\u4fe1\u566a\u6bd4\u662f\u6700\u91cd\u8981\u7684\u6570\u636e\u53c2\u6570\uff1f<\/strong><\/strong><\/h3>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignright\"><img decoding=\"async\" src=\"http:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2023\/06\/052522-Image-1-1.png\" alt=\"\" class=\"wp-image-13215\" \/><\/figure>\n<\/div>\n\n\n<p>\u5728\u5206\u6790\u5316\u5b66\u4e2d\uff0c\u4e3b\u8981\u4efb\u52a1\u5e76\u4e0d\u603b\u662f\u68c0\u6d4b\u548c\u5b9a\u91cf\u4e3b\u8981\u7ec4\u5206\u3002<\/p>\n\n\n\n<p>\u76f8\u53cd\uff0c\u91cd\u70b9\u5f80\u5f80\u662f\u68c0\u6d4b\u75d5\u91cf\u4e0e\u8d85\u75d5\u91cf\u6c34\u5e73\u7684\u7269\u8d28\uff0c\u5982\u6c61\u67d3\u7269\u3001\u6742\u8d28\u6216\u964d\u89e3\u4ea7\u7269\uff0c\u4f8b\u5982\u7528\u4e8e\u8fc7\u7a0b\u76d1\u63a7\u6216\u73af\u5883\u7b5b\u67e5\u5206\u6790\u3002\u5728\u8bb8\u591a\u60c5\u51b5\u4e0b\uff0c\u6837\u54c1\u4e2d\u5173\u6ce8\u7269\u8d28\u6d53\u5ea6\u8303\u56f4\u5dee\u5f02\u5f88\u5927\u3002<\/p>\n\n\n\n<p>\u5982\u679c\u67d0\u79cd\u7269\u8d28\u7684\u68c0\u6d4b\u4fe1\u53f7\u65e0\u6cd5\u4e0e\u5206\u6790\u65b9\u6cd5\u4e0d\u53ef\u907f\u514d\u7684\u57fa\u7ebf\u566a\u58f0\u5145\u5206\u533a\u5206\u2014\u2014\u4e5f\u5c31\u662f\u8bf4\u4fe1\u53f7\u4e0e\u566a\u58f0\u76f8\u8fd1\u751a\u81f3\u66f4\u5c0f\u2014\u2014\u5219\u8be5\u7269\u8d28\u5c06\u65e0\u6cd5\u88ab\u68c0\u51fa\u3002\u8fd9\u5c31\u662f\u4e3a\u4ec0\u4e48SNR\uff08\u4fe1\u566a\u6bd4\uff09\u51b3\u5b9a\u4e86\u6db2\u76f8\u8272\u8c31\u6cd5\uff08LC\uff09\u68c0\u51fa\u9650\u7684\u76f4\u63a5\u539f\u56e0\u3002<\/p>\n\n\n\n<p>\u5728\u8d28\u91cf\u63a7\u5236\u4e2d\uff0c\u5c24\u5176\u662f\u5728\u5236\u836f\u548c\u751f\u7269\u5236\u836f\u5206\u6790\u9886\u57df\uff0c\u5fc5\u987b\u5728\u4e3b\u8981\u6210\u5206\uff08\u5982\u6d3b\u6027\u836f\u7269\u6210\u5206\uff09\u65c1\u68c0\u6d4b\u6742\u8d28\u3002\u5373\u4f7f\u68c0\u6d4b\u5668\u7ebf\u6027\u51b3\u5b9a\u4e86\u76ee\u6807\u5206\u6790\u7269\u7684\u6821\u51c6\u8303\u56f4\uff0c\u4e5f\u5c31\u662f\u4e3b\u8981\u6210\u5206\u4e0e\u6742\u8d28\u4ece\u6700\u4f4e\u5230\u6700\u9ad8\u6d53\u5ea6\u7684\u5de5\u4f5c\u533a\u95f4\uff0cSNR\u4ecd\u7136\u5b9a\u4e49\u4e86\u68c0\u51fa\u9650\uff0c\u7279\u522b\u662f\u5bf9\u4e8e\u6742\u8d28\u800c\u8a00\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/view.highspot.com\/viewer\/626fca34b41d7bcfe51ac8de\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><a href=\"https:\/\/view.highspot.com\/viewer\/626fca34b41d7bcfe51ac8de\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><a href=\"https:\/\/view.highspot.com\/viewer\/626fca34b41d7bcfe51ac8de\"><u>\u5e94\u7528\u7b80\u62a5170\uff1a\u4f7f\u7528UHPLC-DAD\u8fdb\u884c\u5feb\u901f\u5948\u97e6\u62c9\u5e73\u6742\u8d28\u5206\u6790<\/u><\/a>\u5c55\u793a\u4e86\u4e00\u4e2a\u5f88\u597d\u7684\u4f8b\u5b50\uff1a\u5728\u8f83\u4f4eSNR\u6761\u4ef6\u4e0b\uff0c\u7ed3\u5408<a href=\"https:\/\/www.thermofisher.com\/order\/catalog\/product\/VC-D11-A-01?SID=srch-hj-VC-D11-A-01\"><u>Thermo Scientific\u2122 Vanquish\u2122 \u4e8c\u6781\u7ba1\u9635\u5217\u68c0\u6d4b\u5668HL\uff08DAD HL\uff09<\/u><\/a>\u7684\u4f18\u5f02\u7ebf\u6027\u8303\u56f4\u3002\u8fd9\u4f7f\u5f97\u53ef\u4ee5\u5728\u5355\u6b21\u8fd0\u884c\u4e2d\u5c06\u6742\u8d28\u5b9a\u91cf\u81f30.008%\u76f8\u5bf9\u9762\u79ef\uff01<\/p>\n\n\n\n<p>\u5982\u679c\u65e0\u6cd5\u4f18\u5316\u5206\u6790\u65b9\u6cd5\u2014\u2014\u4e5f\u5c31\u662f\u8bf4\u65e0\u6cd5\u589e\u52a0\u6837\u54c1\u7269\u8d28\u4fe1\u53f7\u6216\u964d\u4f4e\u5206\u6790\u8fc7\u7a0b\u4e2d\u7684\u57fa\u7ebf\u566a\u58f0\u2014\u2014\u5219\u53ef\u4ee5\u91c7\u7528\u6570\u5b66\u4fe1\u53f7\u5904\u7406\u65b9\u6cd5\u6765\u5e73\u6ed1\u57fa\u7ebf\u566a\u58f0\u3002<\/p>\n\n\n\n<p>\u4f46\u5fc5\u987b\u6e05\u695a\uff0c\u539f\u59cb\u6570\u636e\u4f1a\u88ab\u4fee\u6539\u2014\u2014\u65e2\u88ab\u4eba\u4e3a\u5904\u7406\u3002\u4e3b\u8981\u6709\u4e24\u79cd\u5904\u7406\u65b9\u5f0f\uff1a\u5728\u6570\u636e\u91c7\u96c6\u8fc7\u7a0b\u4e2d\u6216\u5728\u6570\u636e\u91c7\u96c6\u4e4b\u540e\u8fdb\u884c\u3002<\/p>\n\n\n\n<p>\u4f7f\u7528\u6ee4\u6ce2\u5668\uff08\u5982\u7d2b\u5916\u68c0\u6d4b\u5668\u4e2d\u7684\u65f6\u95f4\u5e38\u6570\uff09\u6765\u5e73\u6ed1\u6d4b\u91cf\u4fe1\u53f7\u662f\u4e00\u79cd\u5e38\u89c1\u505a\u6cd5\u3002\u5bf9\u4e8e\u5927\u591a\u6570\u68c0\u6d4b\u5668\u6765\u8bf4\uff0c\u65f6\u95f4\u5e38\u6570\uff08\u540d\u79f0\u53ef\u80fd\u4e0d\u540c\uff0c\u5982\u54cd\u5e94\u65f6\u95f4\u6216\u4e0a\u5347\u65f6\u95f4\uff0c\u8fd9\u4e9b\u5f80\u5f80\u662f\u6362\u7b97\u540e\u7684\u65f6\u95f4\u5e38\u6570\uff09\u672c\u8d28\u4e0a\u5c31\u662f\u4e00\u79cd\u7535\u5b50\u6ee4\u6ce2\u5668\uff0c\u7528\u4e8e\u964d\u4f4e\u57fa\u7ebf\u566a\u58f0\u3002<\/p>\n\n\n\n<p><img loading=\"lazy\" decoding=\"async\" width=\"998\" height=\"465\" src=\"http:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2023\/06\/052522-Data-Collection-rate-1.jpg\" alt=\"\"> \u5728\u76f8\u540c\u7684\u6570\u636e\u91c7\u96c6\u901f\u7387\u4e0b\uff0c\u4e0d\u540c\u7684\u65f6\u95f4\u5e38\u6570\u4f1a\u5bfc\u81f4\u4e0d\u540c\u7684\u57fa\u7ebf\u566a\u58f0\u6c34\u5e73\u3002\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u5c06\u65f6\u95f4\u5e38\u6570\u4ece2.00\u79d2\u66f4\u6539\u4e3a0.01\u79d2\u65f6\uff0c\u57fa\u7ebf\u566a\u58f0\u6c34\u5e73\u589e\u52a09\u500d\u3002\u90a3\u4e48\uff0c\u4f60\u73b0\u5728\u662f\u5426\u8ba4\u4e3a\u4f7f\u75282.00\u79d2\u7684\u65f6\u95f4\u5e38\u6570\u603b\u662f\u6700\u4f73\u9009\u62e9\uff0c\u56e0\u4e3a\u57fa\u7ebf\u566a\u58f0\u88ab\u964d\u5230\u6700\u4f4e\uff1f<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"toc-hId-2041827353\"><strong><strong>\u5c06\u65f6\u95f4\u5e38\u6570\u8bbe\u7f6e\u4e3a\u8f83\u9ad8\u503c\u53ef\u80fd\u4f1a\u56e0\u8fc7\u5ea6\u5e73\u6ed1\u800c\u5bfc\u81f4\u6570\u636e\u4e22\u5931\u3002\u4e3a\u4ec0\u4e48\uff1f<\/strong><\/strong><\/h3>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignright\"><img decoding=\"async\" src=\"http:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2023\/06\/052522-Filter-Function-1.png\" alt=\"\" class=\"wp-image-13212\" \/><\/figure>\n<\/div>\n\n\n<p>\u5c24\u5176\u662f\u63a5\u8fd1\u57fa\u7ebf\u566a\u58f0\u6c34\u5e73\u7684\u5c0f\u4fe1\u53f7\uff0c\u4f1a\u5728\u9ad8\u5ea6\u4e0a\u88ab\u5927\u5e45\u538b\u4f4e\uff08\u5e76\u5728\u5bbd\u5ea6\u4e0a\u53d8\u5bbd\uff09\uff0c\u540c\u65f6\u4e5f\u88ab\u5e73\u6ed1\u6389\u3002\u56e0\u6b64\uff0c\u4f4e\u6d53\u5ea6\u7269\u8d28\u7ecf\u8fc7\u6ee4\u6ce2\u540e\u53ef\u80fd\u4e0d\u518d\u88ab\u201c\u68c0\u51fa\u201d\uff0c\u56e0\u4e3a\u5b83\u4eec\u4e0d\u518d\u6ee1\u8db3\u68c0\u51fa\u9650\u6807\u51c6\uff08\u7a0d\u540e\u89e3\u91ca\uff09\u3002<\/p>\n\n\n\n<p>\u6b64\u5916\uff0c\u539f\u59cb\u6570\u636e\u662f\u5728\u5e94\u7528\u4e86\u65f6\u95f4\u5e38\u6570\u6ee4\u6ce2\u5668\u540e\u91c7\u96c6\u7684\uff0c\u8fd9\u610f\u5473\u7740\u8be5\u6ee4\u6ce2\u5668\u65e0\u6cd5\u5728\u6570\u636e\u91c7\u96c6\u540e\u201c\u5173\u95ed\u201d\u6216\u66f4\u6539\uff0c\u4ee5\u68c0\u67e5\u8f83\u5c0f\u5cf0\u503c\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/www.thermofisher.com\/order\/catalog\/product\/ISQEC000LC?SID=srch-srp-ISQEC000LC\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><a href=\"https:\/\/www.thermofisher.com\/order\/catalog\/product\/ISQEC000LC?SID=srch-srp-ISQEC000LC\"><u>\u8d5b\u9ed8\u98de\u4e16\u5c14\u79d1\u5b66 ISQ\u2122 EC<\/u><\/a> \u548c <a href=\"https:\/\/www.thermofisher.com\/order\/catalog\/product\/ISQEM-ESI?SID=srch-srp-ISQEM-ESI\" target=\"_blank\" rel=\"noreferrer noopener\">EM<\/a> \u5355\u56db\u6781\u6746\u8d28\u8c31\u4eea\u62e5\u6709\u4e00\u4e2a<a href=\"https:\/\/view.highspot.com\/viewer\/626f7782bc44b7f649ee02d6\" target=\"_blank\" rel=\"noreferrer noopener\"><a href=\"https:\/\/view.highspot.com\/viewer\/626f7782bc44b7f649ee02d6\"><u>\u8272\u8c31\u8fc7\u6ee4\u5668\u529f\u80fd<\/u><\/a><\/a>\u8be5\u8fc7\u6ee4\u5668\u5e94\u7528\u9ad8\u65af\u5e73\u6ed1\u6ee4\u6ce2\u5668\uff0c\u4ee5\u51cf\u5c11\u7531\u7535\u5b50\u6216\u68c0\u6d4b\u5668\u566a\u58f0\u5f15\u5165\u7684\u68c0\u6d4b\u5cf0\u503c\u7684\u4eba\u4e3a\u4fe1\u53f7\u53d8\u5316\u3002<\/p>\n\n\n\n<p>\u5b83\u8fd8\u4f1a\u53bb\u9664\u6240\u6709\u4f4e\u4e8e\u67d0\u4e00\u9608\u503c\u7684\u4fe1\u53f7\uff0c\u8fd9\u4e9b\u4fe1\u53f7\u88ab\u8ba4\u4e3a\u662f\u7535\u5b50\u6216\u68c0\u6d4b\u5668\u566a\u58f0\u3002<\/p>\n\n\n\n<p>\u53ea\u6709\u8d85\u8fc7\u8be5\u9608\u503c\u7684\u4fe1\u53f7\u624d\u4f1a\u88ab\u8bb0\u5f55\u3002<\/p>\n\n\n\n<p>\u82e5\u6ee1\u8db3\u79ef\u5206\u6761\u4ef6\uff0c\u5cf0\u9762\u79ef\u4fdd\u6301\u4e0d\u53d8\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"toc-hId--1365636262\"><strong>\u662f\u5426\u6709\u4e0d\u4f1a\u56e0\u8fc7\u5ea6\u5e73\u6ed1\u800c\u5bfc\u81f4\u6570\u636e\u4e22\u5931\u7684\u66ff\u4ee3\u65b9\u6cd5<\/strong>\uff1f<\/h3>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"http:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2023\/06\/052522-Gaussian-curves-1.jpg\" alt=\"\" class=\"wp-image-13211\" \/><\/figure>\n<\/div>\n\n\n<p>\u6709\uff01\u9ad8\u65af\u5377\u79ef\u3001Savitsky-Golay\u5e73\u6ed1\u3001\u5085\u91cc\u53f6\u53d8\u6362\u6216\u5c0f\u6ce2\u53d8\u6362\u7b49\u6570\u5b66\u51fd\u6570\u90fd\u53ef\u7528\u4e8e\u540e\u7eed\u964d\u566a\u5904\u7406\u3002\u539f\u59cb\u6570\u636e\u4fdd\u6301\u4e0d\u53d8\uff08\u524d\u63d0\u662f\u8ba1\u7b97\u8fc7\u7a0b\u4e2d\u672a\u8986\u76d6\u6216\u5220\u9664\u539f\u59cb\u6570\u636e\uff09\u3002<\/p>\n\n\n\n<p>\u4e0e\u9ad8\u65af\u66f2\u7ebf\u7684\u5377\u79ef\u6e90\u4e8e\u81ea\u76f8\u5173\u5206\u6790\uff0c\u53ef\u7528\u4e8e\u5728\u57fa\u7ebf\u566a\u58f0\u4e2d\u8fdb\u884c\u5cf0\u68c0\u51fa\uff0c\u4f8b\u5982\u5728\u80cc\u666f\u4fe1\u53f7\u2014\u2014\u66f4\u51c6\u786e\u5730\u8bf4\u5728\u68c0\u6d4b\u5668\u57fa\u7ebf\u2014\u2014\u4e2d\u5bf9\u67d0\u7269\u8d28\u8fdb\u884c\u5b9a\u6027\u68c0\u51fa\u3002<\/p>\n\n\n\n<p>\u6bcf\u4e2aCDS\u90fd\u4f7f\u7528\u516c\u5f0f\u548c\u51fd\u6570\uff0c\u4ece\u539f\u59cb\u6570\u636e\u4e2d\u8ba1\u7b97\u5e76\u53ef\u89c6\u5316\u7ed3\u679c\u3002\u4f8b\u5982\uff0cChromeleon\u8f6f\u4ef6\u63d0\u4f9b\u4e86\uff1a<a href=\"https:\/\/view.highspot.com\/viewer\/626f7413d356dcf8db227909\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><a href=\"https:\/\/view.highspot.com\/viewer\/626f7413d356dcf8db227909\"><u>\u5229\u7528Cobra\u548cSmartPeaks\u5b9e\u73b0\u667a\u80fd\u79ef\u5206<\/u><\/a>Cobra \u5cf0\u68c0\u51fa\u7b97\u6cd5\u53ef\u7b80\u5316\u79ef\u5206\uff0c\u5e76\u91c7\u7528\u81ea\u9002\u5e94Savitsky-Golay\u5e73\u6ed1\u51fd\u6570\u5728\u4e0d\u4e22\u5931\u5173\u952e\u4fe1\u606f\u7684\u60c5\u51b5\u4e0b\u53bb\u9664\u57fa\u7ebf\u566a\u58f0\u3002SmartPeaks\u79ef\u5206\u52a9\u624b\u80fd\u591f\u5e2e\u52a9\u5feb\u901f\u4e14\u76f4\u89c2\u5730\u5bf9\u672a\u5206\u79bb\u5cf0\u8fdb\u884c\u79ef\u5206\u3002<\/p>\n\n\n\n<p>\u5728\u8fdb\u4e00\u6b65\u7684\u6570\u636e\u8bc4\u4f30\u6b65\u9aa4\u4e2d\u5e94\u7528\u9ad8\u65af\u5377\u79ef\u3001\u5085\u91cc\u53f6\u53d8\u6362\u6216\u5c0f\u6ce2\u53d8\u6362\uff0c\u53ef\u4ee5\u6210\u4e3a\u4efb\u4f55\u5206\u6790\u6d41\u7a0b\u7684\u91cd\u8981\u7ec4\u6210\u90e8\u5206\u3002\u6b63\u786e\u4e14\u8c28\u614e\u5730\u4f7f\u7528\u8fd9\u4e9b\u65b9\u6cd5\uff0c\u53ef\u4ee5\u6d88\u9664\u80cc\u666f\u566a\u58f0\u800c\u4e0d\u4f1a\u9020\u6210\u6570\u636e\u4e22\u5931\u3002<\/p>\n\n\n\n<p>\u5085\u91cc\u53f6\u53d8\u6362\u88ab\u5e94\u7528\u4e8e\u591a\u79cd\u5206\u6790\u68c0\u6d4b\u6280\u672f\uff0c\u4ece\u5149\u5b66\uff08\u5982UV-VIS\uff09\u5230\u6838\u78c1\u5171\u632f\uff08NMR\uff09\u5149\u8c31\u5b66\u3002\u5176\u4e2d\u975e\u5e38\u8457\u540d\u7684\u662f\u5085\u91cc\u53f6\u53d8\u6362\u7ea2\u5916\uff08FTIR\uff09\uff0c\u5b83\u88ab\u7528\u4e8e<a href=\"https:\/\/www.thermofisher.cn\/cn\/zh\/home\/industrial\/spectroscopy-elemental-isotope-analysis\/molecular-spectroscopy\/fourier-transform-infrared-ftir-spectroscopy.html\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><a href=\"https:\/\/www.thermofisher.com\/us\/en\/home\/industrial\/spectroscopy-elemental-isotope-analysis\/molecular-spectroscopy\/fourier-transform-infrared-ftir-spectroscopy.html\"><u>FTIR\u5149\u8c31\u6cd5<\/u><\/a>\uff0c\u540c\u65f6\u4e5f\u7528\u4e8e<a href=\"https:\/\/www.thermofisher.cn\/cn\/zh\/home\/industrial\/spectroscopy-elemental-isotope-analysis\/molecular-spectroscopy\/microspectroscopy-selection-guide.html\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><a href=\"https:\/\/www.thermofisher.com\/us\/en\/home\/industrial\/spectroscopy-elemental-isotope-analysis\/molecular-spectroscopy\/microspectroscopy-selection-guide.html\"><u>FTIR\u663e\u5fae\u955c<\/u><\/a>\u3002<\/p>\n\n\n\n<p>\u4f60\u77e5\u9053\u5417\uff1f<a href=\"https:\/\/www.thermofisher.cn\/cn\/zh\/home\/industrial\/mass-spectrometry\/liquid-chromatography-mass-spectrometry-lc-ms\/lc-ms-systems\/orbitrap-lc-ms.html\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><a href=\"https:\/\/www.thermofisher.com\/us\/en\/home\/industrial\/mass-spectrometry\/liquid-chromatography-mass-spectrometry-lc-ms\/lc-ms-systems\/orbitrap-lc-ms.html\"><u>\u8d5b\u9ed8\u98de<br>\u2122 Orbitrap\u2122\u6db2\u76f8\u8272\u8c31\u8d28\u8c31\u7cfb\u7edf<\/u><\/a>\u662f\u57fa\u4e8e\u5085\u91cc\u53f6\u53d8\u6362\u79bb\u5b50\u56de\u65cb\u5171\u632f\u6280\u672f\u7684\u5417\uff1f\u5085\u91cc\u53f6\u53d8\u6362\u7528\u4e8e\u5c06\u6355\u83b7\u79bb\u5b50\u7684\u4fe1\u53f7\u9891\u7387\u8f6c\u6362\u4e3a\u5b9e\u9645\u7684\u8d28\u8c31\u56fe\u3002<\/p>\n\n\n\n<p>\u5c0f\u6ce2\u53d8\u6362\u88ab\u89c6\u4e3a\u5085\u91cc\u53f6\u53d8\u6362\u7684\u8fdb\u4e00\u6b65\u53d1\u5c55\u3002\u9664\u4e86\u964d\u566a\u4e4b\u5916\uff0c\u5b83\u8fd8\u53ef\u4ee5\u6210\u529f\u7528\u4e8e\u5cf0\u503c\u5206\u8fa8\uff0c\u4ece\u8f83\u5927\u7684\u5cf0\u4e2d\u63d0\u53d6\u6216\u5206\u79bb\u51fa\u8f83\u5c0f\u7269\u8d28\u7684\u5cf0\u503c\u3002.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"http:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2023\/06\/052522-Fourier-1.jpg\" alt=\"\" class=\"wp-image-13218\" \/><\/figure>\n<\/div>\n\n\n<p>\u901a\u5e38\u60c5\u51b5\u4e0b\uff0c\u6570\u636e\u5e73\u6ed1\u4e0d\u5b9c\u8fc7\u5ea6\u3002<\/p>\n\n\n\n<p>\u5f53\u5e73\u6ed1\u56e0\u5b50\u8fc7\u5927\u6216\u591a\u6b21\u5e73\u6ed1\u65f6\uff0c\u867d\u7136\u57fa\u7ebf\u566a\u58f0\u4f1a\u6309\u9884\u671f\u964d\u4f4e\uff0c\u4f46\u7269\u8d28\u4fe1\u53f7\u9ad8\u5ea6\u4e5f\u53ef\u80fd\u964d\u4f4e\uff0c\u4ece\u800c\u5bfc\u81f4\u4fe1\u53f7\u5bbd\u5ea6\u589e\u5927\u3002\u4fe1\u53f7\uff08\u66f4\u51c6\u786e\u5730\u8bf4\u5cf0\u503c\uff09\u53ef\u80fd\u5c55\u5bbd\u5230\u4e0e\u68c0\u6d4b\u5668\u57fa\u7ebf\u878d\u5408\u7684\u7a0b\u5ea6\uff0c\u53d8\u5f97\u4e0d\u53ef\u89c1\u3001\u4e0d\u53ef\u68c0\u51fa\u3002\u7136\u800c\uff0c\u7531\u4e8e\u539f\u59cb\u6570\u636e\u88ab\u4fdd\u7559\uff0c\u60a8\u53ef\u4ee5\u64a4\u9500\u6570\u636e\u5e73\u6ed1\u6b65\u9aa4\uff0c\u6216\u8005\u5e94\u7528\u5176\u4ed6\u53ef\u80fd\u5e26\u6765\u66f4\u597d\u7ed3\u679c\u7684\u6ee4\u6ce2\u51fd\u6570\u3002\u8fd9\u79cd\u5c1d\u8bd5\u53ef\u4ee5\u4f5c\u4e3a\u5236\u5b9a\u6807\u51c6\u64cd\u4f5c\u89c4\u7a0b\uff08SOP\uff09\u8fc7\u7a0b\u4e2d\u6570\u636e\u8bc4\u4f30\u73af\u8282\u7684\u4e00\u90e8\u5206\u3002<\/p>\n\n\n\n<p>\u7136\u800c\uff0c\u7531\u4e8e\u539f\u59cb\u6570\u636e\u88ab\u4fdd\u7559\uff0c\u60a8\u53ef\u4ee5\u64a4\u9500\u6570\u636e\u5e73\u6ed1\u6b65\u9aa4\uff0c\u6216\u8005\u5e94\u7528\u5176\u4ed6\u53ef\u80fd\u5e26\u6765\u66f4\u597d\u7ed3\u679c\u7684\u6ee4\u6ce2\u51fd\u6570\u3002\u8fd9\u79cd\u5c1d\u8bd5\u53ef\u4ee5\u4f5c\u4e3a\u5236\u5b9a\u6807\u51c6\u64cd\u4f5c\u89c4\u7a0b\uff08SOP\uff09\u8fc7\u7a0b\u4e2d\u6570\u636e\u8bc4\u4f30\u73af\u8282\u7684\u4e00\u90e8\u5206\u3002<\/p>\n\n\n\n<p>\u8fc7\u5ea6\u5e73\u6ed1\u662f\u5426\u4f1a\u9020\u6210\u8fd9\u79cd\u6570\u636e\u7834\u574f\uff0c\u53d6\u51b3\u4e8e\u4fe1\u53f7\u76f8\u5bf9\u57fa\u7ebf\u566a\u58f0\u7684\u9ad8\u5ea6\u2014\u2014\u4e5f\u5c31\u662f\u521d\u59cb SNR\u3002\u5f53SNR\u63a5\u8fd1\u68c0\u51fa\u9650\uff08LOD\uff09\u65f6\uff0c\u901a\u5e38\u6700\u597d\u7684\u65b9\u6cd5\u662f\u6536\u96c6\u66f4\u4f18\u8d28\u7684\u6570\u636e\uff0c\u8fd9\u6837\u53ea\u9700\u8fdb\u884c\u4e00\u6b21\u6216\u65e0\u9700\u8fdb\u884c\u6570\u636e\u5e73\u6ed1\u3002<\/p>\n\n\n\n<p>\u73b0\u5728\u8ba9\u6211\u4eec\u66f4\u8be6\u7ec6\u5730\u4e86\u89e3\u4e00\u4e0b\u68c0\u6d4b\u9650\uff08LOD\uff09\u548c\u5b9a\u91cf\u9650\uff08LOQ\uff09\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"toc-hId--478132581\"><strong><strong>\u4ece\u4fe1\u566a\u6bd4\uff08SNR\uff09\u5230\u68c0\u6d4b\u9650\uff08LOD\uff09\u548c\u5b9a\u91cf\u9650\uff08LOQ\uff09<\/strong><\/strong><\/h3>\n\n\n\n<p>SNR \u53ef\u4f5c\u4e3a\u5224\u65ad\u6307\u6807\uff0c\u7528\u4e8e\u4f30\u8ba1\u67d0\u7269\u8d28\u4fe1\u53f7\u662f\u5426\u80fd\u5728\u68c0\u6d4b\u5668\u57fa\u7ebf\u4e2d\u88ab\u8bc6\u522b\u3001\u4ece\u800c\u5728\u6837\u54c1\u4e2d\u53ef\u88ab\u68c0\u51fa\u3002<\/p>\n\n\n\n<p>\u4e00\u79cd\u65b9\u6cd5\u7684\u7075\u654f\u5ea6\u548c\u68c0\u51fa\u9650\u7531\u6d4b\u91cf\u7cfb\u7edf\u7684\u566a\u58f0\u51b3\u5b9a\u3002<strong>\u566a\u58f0\u6307\u7684\u662f\u6240\u6709\u4e0d\u9700\u8981\u7684\u3001\u7edf\u8ba1\u6027\u6ce2\u52a8\u7684\u4fe1\u53f7\uff0c\u8fd9\u4e9b\u4fe1\u53f7\u53e0\u52a0\u5728\u6d4b\u91cf\u4fe1\u53f7\u4e0a\u3002<\/strong>.<\/p>\n\n\n\n<p>\u5bf9\u4e8e\u8868\u73b0\u51fa\u57fa\u7ebf\u566a\u58f0\u7684\u5206\u6790\u7a0b\u5e8f\uff0c\u53ef\u4ee5\u901a\u8fc7SNR\u4f30\u7b97\u68c0\u51fa\u9650\uff08LOD\uff09\u548c\u5b9a\u91cf\u9650\uff08LOQ\uff09\u3002\u5178\u578b\u4f8b\u5b50\u5305\u62ec\u8272\u8c31\u6cd5\u548c\u5149\u8c31\u6cd5\u3002\u6839\u636e <a href=\"https:\/\/www.ich.org\/page\/quality-guidelines\"><u>ICH\u8d28\u91cf\u6307\u5357<\/u><\/a>&nbsp;<a href=\"https:\/\/database.ich.org\/sites\/default\/files\/Q2%28R1%29%20Guideline.pdf\"><u>Q2(R1)\u7528\u4e8e\u68c0\u51fa\u9650\u548c\u5b9a\u91cf\u9650\u7684\u786e\u5b9a<\/u><\/a>LOD\u548cLOQ\u53ef\u4ee5\u57fa\u4e8e\u4fe1\u566a\u6bd4\uff08SNR\uff09\u4ee5\u53ca\u76ee\u89c6\u8bc4\u4f30\u8fdb\u884c\u786e\u5b9a\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>LOD\u662f\u6307\u5728\u4e0e\u7a7a\u767d\u8fd0\u884c\u7684\u57fa\u7ebf\u566a\u58f0\u76f8\u6bd4\u65f6\uff0c\u80fd\u591f\u53ef\u9760\u68c0\u6d4b\u5230\u7269\u8d28\u4fe1\u53f7\u7684\u6700\u4f4e\u6837\u54c1\u6d53\u5ea6\u3002\u901a\u5e38\u8ba4\u4e3a\u4fe1\u566a\u6bd4\u57282:1\u52303:1\u4e4b\u95f4\u9002\u7528\u4e8e\u68c0\u6d4b\u9650\u7684\u4f30\u7b97\u3002\uff08\u4e0b\u4e00\u7248ICH Q2\u4fee\u8ba2\uff0c\u5373\u8ba1\u5212\u4e8e2023\u5e745\u6708\u5b9e\u65bd\u7684Q2(R2)\uff0c\u5728\u5f53\u524d\u8349\u6848\u4e2d\u6307\u51fa\uff1a\u201c\u4e00\u822c\u8ba4\u4e3a3:1\u7684\u4fe1\u566a\u6bd4\u9002\u7528\u4e8e\u68c0\u51fa\u9650\u7684\u4f30\u7b97\u3002\u201d\u56e0\u6b64\uff0c\u672a\u67652:1\u7684\u4fe1\u566a\u6bd4\u5c06\u4e0d\u518d\u88ab\u63a5\u53d7\u3002\uff09<\/li>\n\n\n\n<li>LOQ\u662f\u6307\u5728\u4e0e\u7a7a\u767d\u8fd0\u884c\u7684\u57fa\u7ebf\u566a\u58f0\u76f8\u6bd4\u65f6\uff0c\u80fd\u591f\u53ef\u9760\u5b9a\u91cf\u7269\u8d28\u4fe1\u53f7\u7684\u6700\u4f4e\u6837\u54c1\u6d53\u5ea6\u3002\u5178\u578b\u7684\u4fe1\u566a\u6bd4\u4e3a10:1\u3002\uff08\u622a\u81f3\u672c\u6587\u53d1\u5e03\u65f6\uff0cICH Q2(R2)\u4e2d\u672a\u63d0\u53ca LOQ \u7684\u53d8\u5316\u3002\uff09<\/li>\n<\/ul>\n\n\n\n<p>ICH\u6307\u5357\u5df2\u7531\u5df4\u897fANVISA\uff08RDC 166\/2017\u548cRDC 413\/2020\uff09\u3001\u6b27\u6d32\u59d4\u5458\u4f1a\uff08CPMP\/ICH\/381\/95\uff09\u3001\u7f8e\u56fdFDA\uff08\u7b2c62\u5377\uff0c\u7b2c96\u671f\uff0c\u7b2c27463-7\u9875\uff09\u3001\u65b0\u52a0\u5761HAS\uff08\u5206\u6790\u9a8c\u8bc1\u6307\u5357\uff09\u3001\u52a0\u62ff\u5927\u536b\u751f\u90e8\uff0815-106599-601\uff09\u3001\u97e9\u56fdMFDS\uff080213-01\u6307\u5357\uff09\u3001\u65e5\u672cMHLW\/PMDA\uff08PMSB\/ELD\u901a\u77e5\u7b2c338\u53f7\uff09\u3001\u4e2d\u56fdNMPA\uff08\u516c\u544a\u7b2c7\u53f7[2020]\uff09\u3001\u745e\u58ebSwissmedic\uff08ICH\u6307\u5357\u81ea\u52a8\u9002\u7528\uff09\u5b9e\u65bd\u3002<\/p>\n\n\n\n<p>\u5728\u66f4\u591a\u56fd\u5bb6\/\u5730\u533a\u7684\u5b9e\u65bd\u4ecd\u5728\u63a8\u8fdb\u4e2d\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"toc-hId-409371100\"><strong><strong>HPLC\u4e2d\u7684SNR\u3001LOD\u548cLOQ<\/strong><\/strong><\/h3>\n\n\n\n<p>\u5206\u6790\u65b9\u6cd5\u91c7\u7528\u7a33\u5065\u53c2\u6570\u5f00\u53d1\uff0c\u56e0\u6b64\u5373\u4f7f\u5728\u7565\u6709\u4e0d\u5b8c\u7f8e\u7684\u5206\u6790\u6761\u4ef6\u4e0b\u4e5f\u80fd\u91cd\u590d\u83b7\u5f97\u7ed3\u679c\u2014\u2014\u56e0\u4e3a\u5206\u6790\u7ed3\u679c\u5fc5\u987b\u53ef\u9760\u3002<\/p>\n\n\n\n<p>\u57fa\u7ebf\u566a\u58f0\u88ab\u5b9a\u4e49\u4e3a\u7a7a\u767d\u8fd0\u884c\u8272\u8c31\u56fe\u57fa\u7ebf\u4e0a\u6700\u5927\u70b9\u4e0e\u6700\u5c0f\u70b9\u4e4b\u95f4\u7684\u5dee\u503c\u3002HPLC\u4e2d\u7684SNR\u6839\u636e\u57fa\u7ebf\u6570\u503c\u8ba1\u7b97\u3002<\/p>\n\n\n\n<p>\u901a\u5e38\uff0c\u5f53\u524d\u8272\u8c31\u56fe\u6216\u4e4b\u524d\u7a7a\u767d\u8fd0\u884c\u4e2d\u7684\u65e0\u5cf0\u533a\u6bb5\u7528\u4e8e\u786e\u5b9a\u57fa\u7ebf\u566a\u58f0\u3002\u7136\u540e\u5c06\u8be5\u57fa\u7ebf\u566a\u58f0\uff08\u5e73\u5747\u9ad8\u5ea6\uff09\u4e0e\u7269\u8d28\u7684\u4fe1\u53f7\u9ad8\u5ea6\u8fdb\u884c\u6bd4\u8f83\u3002\u8fd9\u5c31\u662f\u5173\u952e\u6240\u5728\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"http:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2023\/06\/052522-Sample-and-Blank-Run-1.jpg\" alt=\"\" class=\"wp-image-13217\" \/><\/figure>\n<\/div>\n\n\n<p>\u68c0\u51fa\u9650\u6216\u5b9a\u91cf\u9650\u662f\u6307\u5cf0\u503c\u6216\u7269\u8d28\u4fe1\u53f7\u5fc5\u987b\u81f3\u5c11\u9ad8\u51fa\u57fa\u7ebf\u591a\u5c11\u500d\u7684\u566a\u58f0\u9ad8\u5ea6\u3002\u5b83\u53ef\u4ee5\u6839\u636e\u5177\u4f53\u8981\u6c42\u6709\u6240\u4e0d\u540c\uff0c\u901a\u5e38\u57fa\u4e8e\u5206\u6790\u65b9\u6cd5\u7684\u5b9e\u9645\u5e94\u7528\u6761\u4ef6\u4e0e\u573a\u666f\u3002<\/p>\n\n\n\n<p>\u5728\u591a\u5e74\u652f\u6301\u5404\u5e94\u7528\u9886\u57df\u5e7f\u6cdb\u5ba2\u6237\u3001\u4e14\u5e38\u5e38\u5904\u4e8e\u53d7\u76d1\u7ba1\u73af\u5883\u4e2d\u65f6\uff0c\u6211\u53d1\u73b0LOD\u548cLOQ\u7684\u6700\u4f4e\u4fe1\u566a\u6bd4\u8981\u6c42\u6bd4ICH\u6307\u5357\u66f4\u4e25\u683c\uff0c\u5c24\u5176\u662f\u5728\u66f4\u5177\u6311\u6218\u6027\u7684\u8272\u8c31\u6761\u4ef6\u4e0b\u3002<\/p>\n\n\n\n<p>\u4f5c\u4e3a\u7ecf\u9a8c\u6cd5\u5219\uff0c\u5728\u771f\u5b9e\u6837\u54c1\u4e0e\u5206\u6790\u6761\u4ef6\u4e0b\uff0c\u5e38\u89c1\u7684\u5b9e\u9645\u8981\u6c42\u662f\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>LOD \u7684 SNR \u5728 3:1 \u5230 10:1 \u4e4b\u95f4<\/li>\n\n\n\n<li>LOQ \u7684 SNR \u5728 10:1 \u5230 20:1 \u4e4b\u95f4<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"toc-hId-1296874781\"><strong><strong>\u6700\u540e\u7684\u8bdd<\/strong><\/strong><\/h3>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignright\"><img decoding=\"async\" src=\"http:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2023\/06\/052522-SNR-Comparison-1.jpg\" alt=\"\" class=\"wp-image-13216\" \/><\/figure>\n<\/div>\n\n\n<p>\u5e0c\u671b\u4f60\u80fd\u770b\u5230\uff0c\u5728\u8ba8\u8bba\u6570\u636e\u7ed3\u679c\u8d28\u91cf\u65f6\uff0cSNR \u662f\u6700\u91cd\u8981\u7684\u6307\u5bfc\u6307\u6807\u3002<\/p>\n\n\n\n<p>\u63d0\u5347 SNR \u6709\u591a\u79cd\u529e\u6cd5\uff0c\u4f46\u5982\u679c\u901a\u8fc7\u5e73\u6ed1\u6570\u636e\u6765\u964d\u4f4e\u57fa\u7ebf\u566a\u58f0\uff0c\u53ef\u80fd\u4f1a\u5bfc\u81f4\u6781\u4f4e\u6d53\u5ea6\u7269\u8d28\u5728\u5e73\u6ed1\u540e\u4e0d\u518d\u88ab\u68c0\u51fa\u3002\u8f83\u5c0f\u7684\u7269\u8d28\u5cf0\u4f1a\u88ab\u538b\u5e73\uff0c\u76f4\u5230\u5b83\u4eec\u53ef\u80fd\u4e0d\u518d\u80fd\u4ece\u68c0\u6d4b\u5668\u57fa\u7ebf\u4e0a\u533a\u5206\u51fa\u6765\u3002<\/p>\n\n\n\n<p>\u5728\u5206\u6790\u65b9\u6cd5\u4e2d\u5e94\u7528\u6570\u636e\u8fc7\u6ee4\u6216\u964d\u566a\u529f\u80fd\u4e4b\u524d\uff0c\u8bf7\u5148\u68c0\u67e5\u5728\u8f83\u5c11\u751a\u81f3\u4e0d\u4f7f\u7528\u6570\u636e\u8fc7\u6ee4\u60c5\u51b5\u4e0b SNR \u662f\u5426\u8db3\u591f\uff0c\u4ee5\u514d\u4e22\u5931\u5206\u6790\u7ed3\u679c\u7684\u7ec6\u8282\u3002<\/p>\n\n\n\n<p>\u5982\u56fe\u6240\u793a\uff0c\u6709\u65f6\u8fdb\u4e00\u6b65\u63d0\u9ad8\u4fe1\u566a\u6bd4\uff08SNR\uff09\u53ef\u80fd\u5e76\u6ca1\u6709\u610f\u4e49\u3002<\/p>\n\n\n\n<p>\u4ece\u56fe\u7247\u6765\u770b\uff0cSNR = 80 \u4f3c\u4e4e\u662f\u6700\u6e05\u6670\u7684\u56fe\u7247\uff0c\u4f46\u5728 SNR = 20 \u65f6\uff0c\u6240\u6709\u7ec6\u8282\u90fd\u5df2\u7ecf\u53ef\u4ee5\u5145\u5206\u770b\u89c1\u3002<\/p>\n\n\n\n<p>\u6b64\u5916\uff0c\u5728 SNR = 80 \u65f6\uff0c\u8fd9\u6761\u8857\u9053\u770b\u8d77\u6765\u50cf\u4e00\u6761<strong>\u67cf\u6cb9<\/strong>\u8def\uff0c\u4f46\u5b9e\u9645\u4e0a\u5b83\u662f\u4e00\u6761<strong>\u6c99\u571f<\/strong>\u8def\u3002\u8fd9\u4e00\u7ec6\u8282\u4fe1\u606f\u5728 SNR = 20 \u65f6\u53ef\u80fd\u4f1a\u66f4\u6e05\u695a\u3002<\/p>\n\n\n\n<p>\u5728 SNR = 8 \u65f6\uff0c\u6ca1\u6709\u4eba\u4f1a\u8ba4\u4e3a\u8fd9\u6761\u8def\u662f\u94fa\u4e86\u67cf\u6cb9\u7684\uff0c\u800c\u4e14\u5927\u591a\u6570\u91cd\u8981\u7ec6\u8282\u5df2\u7ecf\u8db3\u591f\u6e05\u6670\u53ef\u89c1\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"toc-hId--2110588834\"><strong><strong>\u9644\u52a0\u4fe1\u606f<\/strong><\/strong><\/h3>\n\n\n\n<p><a href=\"https:\/\/view.highspot.com\/viewer\/626fca34b41d7bcfe51ac8de\" target=\"_blank\" rel=\"noreferrer noopener\">\u4f7f\u7528 UHPLC-DAD \u5feb\u901f\u5206\u6790\u5948\u97e6\u62c9\u5e73\u6742\u8d28<\/a><br><a href=\"https:\/\/view.highspot.com\/viewer\/626f7413d356dcf8db227909\" target=\"_blank\" rel=\"noreferrer noopener\">\u4f7f\u7528Cobra\u548cSmartPeaks\u8fdb\u884c\u7684\u667a\u80fd\u79ef\u5206<\/a><br><a href=\"https:\/\/view.highspot.com\/viewer\/626f7782bc44b7f649ee02d6\" target=\"_blank\" rel=\"noreferrer noopener\">ISQ EC &amp; EM\u5c0f\u8d34\u793a\u2014\u2014\u8272\u8c31\u6ee4\u6ce2\u7684\u5f71\u54cd<\/a><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5728\u6211\u7684\u65e5\u5e38\u5de5\u4f5c\u4e2d\uff0c\u68c0\u6d4b\u5668\u7684\u8bbe\u7f6e\u548c\u53c2\u6570\u8d8a\u6765\u8d8a\u5f97\u4e0d\u5230\u8db3\u591f\u7684\u5173\u6ce8\u548c\u91cd\u89c6\u3002 \u4f46\u5728\u544a\u8bc9\u4f60\u5173\u4e8e\u6b63\u786e\u6570\u636e\u901f\u7387\u53ca\u76f8\u5173\u65f6\u95f4\u5e38\u6570\u8bbe<\/p>\n","protected":false},"author":1852,"featured_media":717,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_monsterinsights_skip_tracking":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[49],"tags":[74,75,76],"division":[50],"class_list":{"0":"post-716","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-49","8":"tag-hplc","9":"tag-snr","10":"tag-76","11":"division-cmd","12":"entry"},"_selected_authors":[1475],"_selected_reviewers":[],"acf":[],"yoast_head":"<!-- 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