{"id":748,"date":"2026-03-09T09:38:56","date_gmt":"2026-03-09T09:38:56","guid":{"rendered":"https:\/\/www.thermofisher.com\/blog\/accelerating-science-in-china\/?p=748"},"modified":"2026-05-13T02:49:05","modified_gmt":"2026-05-13T02:49:05","slug":"review-of-analytical-methods-for-quantifying-amp-profiling","status":"publish","type":"post","link":"https:\/\/www.thermofisher.cn\/blog\/review-of-analytical-methods-for-quantifying-amp-profiling\/","title":{"rendered":"\u91c7\u7528\u5e26\u7535\u6c14\u6eb6\u80f6\u68c0\u6d4b\u5668(CAD)\u5bf9\u805a\u5c71\u68a8\u916f\u8fdb\u884c\u5b9a\u91cf\u548c\u5206\u6790"},"content":{"rendered":"\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/www.thermofisher.cn\/cn\/zh\/home\/industrial\/chromatography\/download-solution.html?icid=cn-blog-cmd\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"176\" src=\"http:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/779-\u00d7-134-CMD-1024x176.jpg\" alt=\"\" class=\"wp-image-1799\" srcset=\"https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/779-\u00d7-134-CMD-1024x176.jpg 1024w, https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/779-\u00d7-134-CMD-300x52.jpg 300w, https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/779-\u00d7-134-CMD-768x132.jpg 768w, https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/779-\u00d7-134-CMD-1536x264.jpg 1536w, https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/779-\u00d7-134-CMD-2048x352.jpg 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure>\n\n\n\n\n\n<p>\u805a\u5c71\u68a8\u916f\uff08PS\uff09\u662f\u4e00\u7c7b\u4e24\u6027\u975e\u79bb\u5b50\u8868\u9762\u6d3b\u6027\u5242\uff0c\u88ab\u7528\u4f5c\u4e73\u5316\u5242\u3001\u7a33\u5b9a\u5242\u548c\u589e\u6eb6\u5242\uff0c\u5e7f\u6cdb\u5e94\u7528\u4e8e\u5236\u836f\u548c\u751f\u7269\u5236\u836f\u914d\u65b9\u3001\u98df\u54c1\u751a\u81f3\u5316\u5986\u54c1\u4e2d\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignright\"><img decoding=\"async\" src=\"http:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2023\/06\/17705-og-1-300x169.jpg\" alt=\"\" class=\"wp-image-12116\" \/><\/figure>\n<\/div>\n\n\n<p>\u5bf9\u805a\u5c71\u68a8\u916f\u8fdb\u884c\u51c6\u786e\u6d4b\u91cf\u5bf9\u4e8e\u4ea7\u54c1\u7684\u8d28\u91cf\u548c\u5b89\u5168\u81f3\u5173\u91cd\u8981\u3002\u95ee\u9898\u5728\u4e8e\uff0c\u5927\u591a\u6570\u5e02\u552e\u7684\u805a\u5c71\u68a8\u916f\u6750\u6599\u90fd\u662f\u7531\u6570\u767e\u79cd\u5206\u5b50\u7ec4\u6210\u7684\u590d\u6742\u5f02\u8d28\u6df7\u5408\u7269\uff0c\u5176\u4e2d\u8fd8\u5305\u62ec\u4f4e\u542b\u91cf\u7684\u6742\u8d28\u548c\u964d\u89e3\u4ea7\u7269\u7b49\u6210\u5206\u3002<\/p>\n\n\n\n<p>\u7528\u4e8e\u901a\u8fc7\u9ad8\u6548\u6db2\u76f8\u8272\u8c31\uff08HPLC\uff09\u5206\u6790\u805a\u5c71\u68a8\u916f\u7684\u4e24\u79cd\u5e38\u89c1\u5206\u6790\u65b9\u6cd5\u662f\uff1a\u7528\u4e8e\u5b9a\u91cf\u7684\u5355\u5cf0\u6cd5\uff0c\u4ee5\u53ca\u80fd\u591f\u6d4b\u91cf\u5e76\u5b9a\u91cf\u591a\u4e2a\u7ec4\u5206\u4ee5\u5224\u65ad\u8d28\u91cf\u7684\u6210\u5206\u5206\u6790\u6cd5\u3002<\/p>\n\n\n\n<p>\u56f4\u7ed5\u8fd9\u4e24\u79cd\u65b9\u6cd5\u5df2\u53d1\u8868\u7684\u65b9\u6cd5\u6709\u6240\u4e0d\u540c\uff0c\u5176\u4e2d\u4e00\u79cd\u53d8\u4f53\u4e0e\u68c0\u6d4b\u5668\u7c7b\u578b\u6709\u5173\u3002\u5e38\u7528\u7684\u65b9\u6cd5\u5305\u62ec\u8d28\u8c31\u3001\u5e26\u7535\u6c14\u6eb6\u80f6\u68c0\u6d4b\uff08CAD\uff09\u6216\u84b8\u53d1\u5149\u6563\u5c04\u68c0\u6d4b\uff08ELSD\uff09\u3002<\/p>\n\n\n\n<p>\u672c\u535a\u5ba2\u5c06\u63a2\u8ba8\u5bfc\u81f4\u805a\u5c71\u68a8\u916f\u5316\u5408\u7269\u590d\u6742\u6027\u7684\u5316\u5b66\u539f\u7406\uff0c\u5bf9\u6bd4\u5355\u5cf0\u6cd5\u4e0e\u6210\u5206\u5206\u6790\u6cd5\uff0c\u5e76\u5f3a\u8c03\u4e3a\u4f55CAD\u5728\u805a\u5c71\u68a8\u916f\u5206\u6790\u4e2d\u4f18\u4e8eELSD\u3002<\/p>\n\n\n\n<p><strong>\u5bfc\u81f4\u805a\u5c71\u68a8\u916f\u7ec4\u6210\u590d\u6742\u4e14\u591a\u53d8\u7684\u5316\u5b66\u539f\u7406<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignright\"><img decoding=\"async\" src=\"http:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2023\/06\/Polysorbate-uses-1-300x300.jpg\" alt=\"\" class=\"wp-image-12721\" \/><\/figure>\n<\/div>\n\n\n<p>\u5728\u590d\u6742\u6df7\u5408\u7269\u4e2d\u8868\u5f81\u805a\u5c71\u68a8\u916f\u5316\u5408\u7269\u7684\u7eaf\u5ea6\u3001\u7a33\u5b9a\u6027\u53ca\u964d\u89e3\u4ea7\u7269\u901a\u5e38\u9762\u4e34\u4e00\u4e9b\u5206\u6790\u6311\u6218\uff0c\u539f\u56e0\u5305\u62ec\uff1a\uff08I\uff09\u8d77\u59cb\u6750\u6599\u4e3a\u4e0d\u7eaf\u6df7\u5408\u7269<a href=\"https:\/\/www.pharmaexcipients.com\/wp-content\/uploads\/attachments\/White+Paper+-+Focus+on+eliminating+formulation+impurities+drives+introduction+of+Super+Refined+polysorbate+products+%281%29.pdf?t=1437586270\" target=\"_blank\" rel=\"noreferrer noopener\">\u8d77\u59cb\u6750\u6599\u662f\u4e0d\u7eaf\u7684\u6df7\u5408\u7269<\/a>\uff08II\uff09PS\u5bb9\u6613\u964d\u89e3\uff0c\u4e14\uff08III\uff09\u5728<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20950816\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u6700\u7ec8\u4ea7\u54c1\u4e2d<\/a>PS\u4ec5\u7ea6\u4e3a\u9884\u671f\u7ed3\u6784\u768420%\u3002<br><br>\n\u7531\u4e8e\u5408\u6210\u8fc7\u7a0b\u7684\u4e0d\u4e00\u81f4\u6027\uff0c\u5316\u5b66\u7279\u5f81\u53ef\u80fd\u4f1a\u56e0\u6279\u6b21\u800c\u5f02<a href=\"https:\/\/academic.oup.com\/chromsci\/article\/50\/7\/598\/298661\" target=\"_blank\" rel=\"noreferrer noopener\">\u5e76\u53ef\u80fd\u5f71\u54cdPS\u5728\u6db2\u4f53\u914d\u65b9\u4e2d\u7684\u8868\u73b0<\/a>\u3002\u8fd9\u4e9b\u5dee\u5f02\u4f1a\u5f71\u54cd\u6e38\u79bb\u8102\u80aa\u9178\u6742\u8d28\u7684\u6eb6\u89e3\u5ea6\uff0c\u5bfc\u81f4\u6700\u7ec8\u4ea7\u54c1\u4e2d\u51fa\u73b0\u4e0d\u9700\u8981\u7684\u9897\u7c92\u7269\u3002<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.molpharmaceut.5b00310\" target=\"_blank\" rel=\"noreferrer noopener\">\u7531\u76d1\u7ba1\u8981\u6c42\u5b9a\u4e49<\/a>\u5728\u6700\u7ec8\u4ea7\u54c1\u4e2d\u3002\u7531\u2026\u2026\u5b9a\u4e49\u7684\u76d1\u7ba1\u8981\u6c42<a href=\"https:\/\/www.edqm.eu\/en\/news\/european-pharmacopoeia-updates-testing-particulate-contamination-pharmaceutical-preparations\" target=\"_blank\" rel=\"noreferrer noopener\">\u6b27\u6d32\u836f\u5178<\/a>\u548c<a href=\"https:\/\/www.usp.org\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u7f8e\u56fd\u836f\u5178790<\/a>\u5bf9\u6ce8\u5c04\u7528\u836f\u7269\u4e2d\u9897\u7c92\u7684\u5b58\u5728\u6709\u4e25\u683c\u89c4\u5b9a\uff0c\u56e0\u4e3a\u8fd9\u4e9b\u836f\u7269\u901a\u5e38\u5e94\u201c\u57fa\u672c\/\u5b9e\u9645\u4e0a\u4e0d\u542b\u53ef\u89c1\u9897\u7c92\u201d\u3002\u800c\u6ce8\u5c04\u5242\u4e2d\u9897\u7c92\u7684\u5f62\u6210\u662f\u5bfc\u81f4<a href=\"https:\/\/www.longdom.org\/open-access\/particulate-matter-in-injectables-main-cause-for-recalls-2329-6887-3-e128.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">\u53ec\u56de<\/a>\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"toc-hId-2041885944\"><strong><strong>\u8ba9\u6211\u4eec\u66f4\u6df1\u5165\u5730\u63a2\u8ba8\u4e00\u4e0b\u5408\u6210\u8def\u7ebf\u3002<\/strong><\/strong><\/h3>\n\n\n\n<p>\u805a\u5c71\u68a8\u9187\u916f\u662f\u901a\u8fc7\u805a\u6c27\u4e59\u70ef\u5c71\u68a8\u9187\u4e0e\u8102\u80aa\u9178\u916f\u5316\u53cd\u5e94\u751f\u6210\u7684\u3002<\/p>\n\n\n\n<p>\u4e0d\u540c\u7c7b\u578b\u7684PS\u5316\u5408\u7269\u2014\u2014\u5982\u805a\u5c71\u68a8\u9187\u916f20\uff08PS20\uff09\u548c\u805a\u5c71\u68a8\u9187\u916f80\uff08PS80\uff09\u2014\u2014\u662f\u7531\u6bcd\u4f53\u9178\u94fe\u957f\u6765\u5b9a\u4e49\u7684\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PS20\u6765\u6e90\u4e8e<a href=\"https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Lauric-acid\" target=\"_blank\" rel=\"noreferrer noopener\">\u6708\u6842\u9178<\/a><\/li>\n\n\n\n<li>PS80\u6765\u6e90\u4e8e<a href=\"https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Oleic-acid\" target=\"_blank\" rel=\"noreferrer noopener\">\u6cb9\u9178<\/a><\/li>\n<\/ul>\n\n\n\n<p>\u8d77\u59cb\u539f\u6599\u6765\u81ea\u5929\u7136\u6742\u8d28\u6e90\uff0c\u542b\u6709\u8bb8\u591a\u6742\u8d28\uff0c\u5982\u5176\u4ed6\u53ef\u916f\u5316\u8102\u80aa\uff0c\u8fd9\u662f\u6bcf\u4e2a\u5316\u5b66\u5bb6\u7684\u5669\u68a6\u3002\u4f8b\u5982\uff0c\u6cb9\u9178\u5e38\u5e38\u88ab\u5176\u4ed6\u8102\u80aa\u9178\u5982\u68d5\u6988\u9178\u3001\u4e9a\u6cb9\u9178\u548c\u786c\u8102\u9178\u6c61\u67d3\u3002<\/p>\n\n\n\n<p>\u5316\u5b66\u6210\u5206\u7684\u53d8\u5316\u53ef\u80fd\u4f1a\u5728\u4e0d\u540c\u6279\u6b21\u4e4b\u95f4\u53d1\u751f\uff0c\u5e76\u53ef\u80fd\u5f71\u54cdPS\u5728\u751f\u7269\u6cbb\u7597\u5236\u5242\u4e2d\u7684\u8868\u73b0\u3002\u8fd9\u4e9b\u5dee\u5f02\u4f1a\u5f71\u54cd\u6e38\u79bb\u8102\u80aa\u9178\u6742\u8d28\u7684\u6eb6\u89e3\u5ea6\uff0c\u5bfc\u81f4\u5f62\u6210<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.molpharmaceut.5b00310\" target=\"_blank\" rel=\"noreferrer noopener\">\u7531\u76d1\u7ba1\u8981\u6c42\u5b9a\u4e49<\/a>\u5728\u6700\u7ec8\u4ea7\u54c1\u4e2d\u3002\n\u5c71\u68a8\u9187\u53ca\u5176\u524d\u4f53\u548c\u526f\u4ea7\u7269\u5f02\u5c71\u68a8\u9187\uff0c\u4ee5\u53ca\u4e3b\u4ea7\u7269\u548c\u526f\u4ea7\u7269\u4e0d\u540c\u7a0b\u5ea6\u7684\u4e59\u6c27\u57fa\u5316\u7684\u989d\u5916\u5b58\u5728\uff0c\u53ef\u4ee5<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0022354917301570\" target=\"_blank\" rel=\"noreferrer noopener\">\u5bfc\u81f4\u6df7\u5408\u7269\u4e2d\u5305\u542b\u8d85\u8fc71,500\u79cd\u7ec4\u5206<\/a>\u3002\u6240\u4ee5\uff0c\u4f60\u80fd\u770b\u51faPS\u751f\u4ea7\u8fc7\u7a0b\u5f88\u5feb\u5c31\u53d8\u5f97\u590d\u6742\u4e86\u5417\uff1f<\/p>\n\n\n\n<p>\u90a3\u8fd8\u4e0d\u5305\u62ec\u964d\u89e3\u4ea7\u7269\u5462\uff01<\/p>\n\n\n<div class=\"wp-block-image wp-image-13458\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"http:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2023\/06\/Synthesis-of-PS80-2.png\" alt=\"\" class=\"wp-image-13458\" \/><figcaption class=\"wp-element-caption\">PS80\u7684\u5408\u6210\u663e\u793aPOE\u4ea7\u7269\u7684\u6df7\u5408\u7269\u3002\u56fe\u7247\u6539\u7f16\u81ea\uff1aLi\u7b49\u4eba\uff0cAnal. Chem., 2014, 86, 5150-5157\u3002<\/figcaption><\/figure>\n<\/div>\n\n\n<p><strong style=\"color: revert;font-size: revert\"><strong>\u6211\u4eec\u5bf9\u591a\u7d22\u8d1d\u7279\u5728\u6eb6\u6db2\u4e2d\u964d\u89e3\u7684\u4e86\u89e3<\/strong><\/strong><\/p>\n\n\n\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0378517318307439\" target=\"_blank\" rel=\"noopener nofollow noreferrer\">\u7814\u7a76\u8868\u660e<\/a>PS\u901a\u8fc7\u81ea\u6c27\u5316\u548c\u6c34\u89e3\u9014\u5f84\u964d\u89e3\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31449\/\" target=\"_blank\" rel=\"noopener nofollow noreferrer\">\u81ea\u6c27\u5316\u4f5c\u7528<\/a>PS\u7684\u81ea\u6c27\u5316\u503e\u5411\u4e8e\u53d1\u751f\u5728\u805a\u6c27\u4e59\u70ef\uff08POE\uff09\u4fa7\uff0c\u901a\u8fc7\u94fe\u5f0f\u4f20\u64ad\u8fc7\u6c27\u5316\u7269\u5f62\u6210\uff0c\u5e76\u5bfc\u81f4\u751f\u6210<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0022354921004184\" target=\"_blank\" rel=\"noopener nofollow noreferrer\">\u916e\u3001\u919b\u548c\u8fc7\u6c27\u5316\u7269<\/a>\n<ul class=\"wp-block-list\">\n<li>\u5149\u3001\u70ed\u4ee5\u53ca\u94dc\u548c\u94c1\u7b49\u5177\u6709\u6c27\u5316\u8fd8\u539f\u6d3b\u6027\u7684\u91d1\u5c5e\u4f1a\u89e6\u53d1\u6c27\u5316\u964d\u89e3\u8fc7\u7a0b<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>PS\u7684\u6c34\u89e3\u662f\u901a\u8fc7\u916f\u952e\u65ad\u88c2\u53d1\u751f\u7684\uff0c\u4ea7\u751f\u6613\u4e8e\u6c89\u6dc0\u7684\u6e38\u79bb\u8102\u80aa\u9178\uff0c\u4ee5\u53ca\u7ecf\u6c27\u5316\u4fee\u9970\u7684POE\u5316\u5408\u7269\n<ul class=\"wp-block-list\">\n<li>\u589e\u52a0<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0022354915322917\" target=\"_blank\" rel=\"noopener nofollow noreferrer\">\u70ed\u91cf<\/a>\u548c pH \u503c\u53ef\u4ee5\u52a0\u901f\u88c2\u89e3\u53cd\u5e94<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u56e0\u6b64\uff0c\u5c55\u671b\u4ea7\u54c1\u5f00\u53d1\uff0c\u4f60\u5f53\u7136\u9700\u8981\u4e00\u79cd\u53ef\u9760\u7684\u5206\u6790\u65b9\u6cd5\u6765\u5206\u79bb\u548c\u9274\u5b9a\u6765\u81ea\u5408\u6210\u53ca\u964d\u89e3\u9014\u5f84\u7684\u590d\u6742 PS \u6210\u5206\u6df7\u5408\u7269\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"toc-hId--478073990\"><strong><strong>\u901a\u8fc7 HPLC \u5206\u6790\u591a\u805a\u5c71\u68a8\u9187\u916f\u8fdb\u884c\u5b9a\u91cf\u548c\u5206\u6790\u7684\u6210\u719f\u65b9\u6cd5<\/strong><\/strong><\/h3>\n\n\n\n<p>\u5b9a\u91cf\u548c\u5206\u6790\u662f\u4f60\u5728\u6eb6\u6db2\u4e2d\u5206\u6790 PS \u7684\u4e24\u79cd\u65b9\u5f0f\uff0c\u4f46\u4f60\u7684\u7ed3\u679c\u53d6\u51b3\u4e8e\u68c0\u6d4b\u65b9\u6cd5\u548c\u5de5\u4f5c\u6d41\u7a0b\u7c7b\u578b\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u7528\u4e8e PS \u5b9a\u91cf\u7684\u5355\u5cf0\u6cd5\u6d89\u53ca\u4f7f\u7528\u5355\u4e00\u8272\u8c31\u67f1\u548c\u68c0\u6d4b\u5668\u5c06\u6240\u6709\u5316\u5b66\u7ec4\u5206\u6d17\u8131\u51fa\u6765\u3002\u6210\u719f\u7684\u64cd\u4f5c\u6d41\u7a0b\u91c7\u7528<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0021967318311816\" target=\"_blank\" rel=\"noopener nofollow noreferrer\">HPLC-CAD\uff08\u9ad8\u6548\u6db2\u76f8\u8272\u8c31-\u7535\u8377\u6c14\u6eb6\u80f6\u68c0\u6d4b\u5668\uff09<\/a>\u6216<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7078541\/\" target=\"_blank\" rel=\"noopener nofollow noreferrer\">HPLC-ELSD\uff08\u9ad8\u6548\u6db2\u76f8\u8272\u8c31-\u84b8\u53d1\u5149\u6563\u5c04\u68c0\u6d4b\u5668\uff09<\/a>\u5206\u6790\u3002<\/li>\n\n\n\n<li>\u9ad8\u7ea7\u65b9\u6cd5\u5305\u62ec\u5bf9\u914d\u65b9\u4e2d\u5404\u4e2a\u7ec4\u5206\u8fdb\u884c\u5206\u6790\u548c\u5b9a\u91cf\uff0c\u8fd9\u662f\u4efb\u4f55\u6ce8\u5c04\u5242\u5236\u5242\u90fd\u5fc5\u987b\u8fdb\u884c\u7684\u64cd\u4f5c\u3002\u5206\u6790\u65b9\u6cd5\u53ef\u4ee5\u91c7\u7528\u5355\u4e00\u8272\u8c31\u67f1\u548c\u68c0\u6d4b\u5668\uff0c\u6216\u66f4\u5148\u8fdb\u7684\u4e8c\u7ef4\u6db2\u76f8\u8272\u8c31\uff082D-LC\uff09\u6280\u672f\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u4ee5\u4e0b\u662f\u4e00\u4e9b\u5e38\u89c1\u5df2\u53d1\u8868\u65b9\u6cd5\u7684\u7b80\u8981\u8bf4\u660e\uff1a<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><span style=\"color: #ffffff\"><strong><strong>\u65b9\u6cd5<\/strong><\/strong><\/span><\/td><td><strong>\u5355\u5cf0\u5e26\u5b9a\u91cf\u7684\u6210\u5206\u5206\u6790<\/strong><\/td><td><strong>\u4e0d\u5e26\u5b9a\u91cf\u7684\u6210\u5206\u5206\u6790<\/strong>\/<strong>\u5e26\u5b9a\u91cf\u7684\u6210\u5206\u5206\u6790<\/strong><\/td><td><strong>\u5b9a\u91cf\u91cf\u5316<\/strong><\/td><td><strong>\u914d\u65b9\u5206\u6790<\/strong><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td>\u5206\u6790\u7684\u5de5\u4f5c\u6d41\u7a0b<\/td><td>\u5355\u4e00\u8272\u8c31\u67f1 &amp; \u5355\u4e00\u68c0\u6d4b\u5668<\/td><td>\u5355\u4e00\u8272\u8c31\u67f1 &amp; \u5355\u4e00\u68c0\u6d4b\u5668<\/td><td>\u5355\u4e00\u8272\u8c31\u67f1 &amp; \u5355\u4e00\u68c0\u6d4b\u5668<\/td><td>\u4e24\u67f1\u6cd5 &amp; \u591a\u68c0\u6d4b\u5668<\/td><\/tr><tr><td>\u4f18\u70b9<\/td><td>\u6d4b\u91cf\u6eb6\u6db2\u4e2dPS\u7684\u603b\u6d53\u5ea6\uff0c\u4f46\u65e0\u6cd5\u533a\u5206\u4e0d\u540c\u7684\u916f\u7c7b<\/td><td>\u63d0\u4f9bPS\u4e9a\u79cd\u7684\u6307\u7eb9\u56fe\u8c31\u53ca\u53ef\u80fd\u7684\u964d\u89e3\u9014\u5f84<\/td><td>\u663e\u793a\u5b58\u5728\u54ea\u4e9bPS\u5316\u5408\u7269\u548c\u8102\u80aa\u9178\u94fe\u53ca\u5176\u4e30\u5ea6<\/td><td>\u53ef\u6d1e\u5bdfPS\u79cd\u7c7b\u5728\u5b9e\u65f6\u7a33\u5b9a\u6027\u6837\u54c1\u4e2d\u7684\u884c\u4e3a<\/td><\/tr><tr><td>\u6ce8\u610f\u4e8b\u9879<\/td><td>\u7075\u654f\u5ea6\u9ad8\uff0c\u4f46\u4e5f\u4f1a\u6d4b\u91cf\u5e72\u6270\u7269\uff0c\u5bfc\u81f4\u7ed3\u679c\u9ad8\u4f30<\/td><td>\u663e\u793a\u4e0d\u540c\u751f\u4ea7\u6279\u6b21\u4e4b\u95f4PS\u916f\u7c7b\u4e30\u5ea6\u7684\u5dee\u5f02<\/td><td>\u53ef\u80fd\u63ed\u793a\u539f\u6750\u6599\u7684\u8d28\u91cf\u5e76\u8bc4\u4f30\u6279\u6b21\u95f4\u7684\u5dee\u5f02\u6027<\/td><td>\u9700\u8981\u901a\u8fc7\u79bb\u7ebf\u6216\u5728\u7ebf\u5de5\u4f5c\u6d41\u7a0b\u53bb\u9664\u86cb\u767d\u8d28\u5e72\u6270<\/td><\/tr><tr><td>\u53c2\u8003\u6587\u732e<\/td><td><a href=\"https:\/\/cdnmedia.eurofins.com\/corporate-eurofins\/media\/12146633\/9424_polysorbate-20-assay_web.pdf\" target=\"_blank\" rel=\"noopener nofollow noreferrer\">\u901a\u8fc7RP-HPLC\u5728\u6cbb\u7597\u6027\u6297\u4f53\u5236\u5242\u4e2d\u5f00\u53d1\u548c\u9a8c\u8bc1\u805a\u5c71\u68a8\u9187\u916f20\u68c0\u6d4b\u65b9\u6cd5<\/a><\/td><td><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0022354921004184\" target=\"_blank\" rel=\"noopener nofollow noreferrer\">\u901a\u8fc7\u6db2\u76f8\u8272\u8c31-\u8d28\u8c31\u6cd5\u5bf9\u805a\u5c71\u68a8\u9187\u916f80\u8fdb\u884c\u8868\u5f81\uff0c\u4ee5\u4e86\u89e3\u5176\u6613\u53d7\u5f71\u54cd\u6027<\/a><\/td><td><a href=\"https:\/\/assets.thermofisher.com\/TFS-Assets\/CMD\/Application-Notes\/an-73979-hplc-charged-aerosol-detection-polysorbate-an73979-en.pdf\" target=\"_blank\" rel=\"nofollow noopener\">\u5229\u7528\u9ad8\u6548\u6db2\u76f8\u8272\u8c31\u7ed3\u5408\u8d28\u8c31\u548c\u5e26\u7535\u6c14\u6eb6\u80f6\u68c0\u6d4b\u5bf9\u805a\u5c71\u68a8\u9187\u916f80\u8fdb\u884c\u5206\u6790<\/a><\/td><td><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/ac5009628\" target=\"_blank\" rel=\"noopener nofollow noreferrer\">\u6cbb\u7597\u6027\u5355\u514b\u9686\u6297\u4f53\u5236\u5242\u4e2d\u805a\u5c71\u68a8\u9187\u916f20\u7684\u8868\u5f81\u4e0e\u7a33\u5b9a\u6027\u7814\u7a76<\/a><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"toc-hId-409429691\"><\/h3>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"toc-hId-1296933372\"><strong><strong>\u4e3a\u4ec0\u4e48CAD\u6bd4ELSD\u66f4\u9002\u5408\u8868\u5f81\u805a\u5c71\u68a8\u9187\u916f\uff1f<\/strong><\/strong><\/h3>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignright\"><img decoding=\"async\" src=\"http:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2023\/06\/CAD-vs-ELSD-for-polysorbates-1-300x300.jpg\" alt=\"\" class=\"wp-image-12723\" \/><\/figure>\n<\/div>\n\n\n<p>\u5728\u5c1d\u8bd5\u5b9a\u91cf\u67d0\u79cd\u5316\u5408\u7269\u65f6\uff0c\u6db2\u76f8\u8272\u8c31\u5206\u6790\u4eba\u5458\u901a\u5e38\u4f1a\u91c7\u7528HPLC-UV\u65b9\u6cd5\u3002\u867d\u7136\u8fd9\u79cd\u65b9\u6cd5\u5bf9\u4e8e\u542b\u6709\u53d1\u8272\u56e2\u7684\u5316\u5408\u7269\u6548\u679c\u5f88\u597d\uff0c\u4f46\u5bf9\u4e8e\u4e0d\u5177\u5907\u5438\u5149\u7ed3\u6784\u7684\u5316\u5408\u7269\u5219\u51e0\u4e4e\u65e0\u7528\u3002<\/p>\n\n\n\n<p>\u7531\u4e8e\u5927\u591a\u6570PS\u7f3a\u4e4f\u53d1\u8272\u56e2\uff0c\u56e0\u6b64\u9700\u8981\u91c7\u7528\u4e0d\u540c\u7684\u5206\u6790\u65b9\u6cd5\u8fdb\u884c\u5b9a\u91cf\uff0c\u5982CAD\u6216ELSD\u3002<\/p>\n\n\n\n<p>\u4f46\u54ea\u79cd\u68c0\u6d4b\u5668\u6700\u597d\uff0c<a href=\"https:\/\/apps.thermoscientific.com\/media\/cmd\/hypersite-events\/HPLC-2014\/posters\/PN70990_HPLC_2014-CAD-vs-ELSD.pdf\"><u>CAD\u8fd8\u662fELSD<\/u><\/a>?<\/p>\n\n\n\n<p>CAD\u6bd4ELSD\u66f4\u654f\u611f\uff0c\u5e76\u4e14\u53d7\u5206\u6790\u7269\u5149\u5b66\u6027\u8d28\u5f71\u54cd\u8f83\u5c0f\u3002CAD\u8fd8\u5177\u6709\u66f4\u597d\u7684\u5747\u4e00\u54cd\u5e94\uff0c\u8fd9\u5bf9\u4e8e\u65e0\u6807\u51c6\u5b9a\u91cf\u81f3\u5173\u91cd\u8981\uff0c\u52a8\u6001\u8303\u56f4\u66f4\u5e7f\uff0c\u6821\u51c6\u66f2\u7ebf\u66f4\u7b80\u5355\uff0c\u800c\u4e14\u4f7f\u7528\u8d77\u6765\u4e5f\u66f4\u65b9\u4fbf\u3002<span class=\"lia-inline-image-display-wrapper lia-image-align-right\" style=\"width: 400px\"><\/span><\/p>\n\n\n\n\n\n\n\n<p><a href=\"https:\/\/apps.thermoscientific.com\/media\/cmd\/hypersite-events\/HPLC-2014\/posters\/PN70990_HPLC_2014-CAD-vs-ELSD.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">CAD or ELSD<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"toc-hId--2110530243\"><strong><strong>\u901a\u8fc7\u5e26\u7535\u6c14\u6eb6\u80f6\u68c0\u6d4b\uff0c\u8ba9\u60a8\u7684\u805a\u5c71\u68a8\u9187\u916f\u5206\u6790\u66f4\u8fdb\u4e00\u6b65<\/strong><\/strong><\/h3>\n\n\n\n<p>\u5e0c\u671b\u672c\u535a\u5ba2\u4e2d\u56de\u987e\u7684\u4fe1\u606f\u80fd\u5e2e\u52a9\u60a8\u6307\u5bfc\u5982\u4f55\u63d0\u5347\u672a\u6765\u7684PS\u5206\u6790\u3002<\/p>\n\n\n\n<p>\u65e0\u8bba\u60a8\u9009\u62e9\u54ea\u79cd\u5de5\u4f5c\u6d41\u7a0b\u2014\u2014\u5355\u7ef4\u8fd8\u662f\u591a\u7ef4\u2014\u2014\u90fd\u5e94\u8be5\u6beb\u65e0\u7591\u95ee\u5730\u9009\u62e9<a href=\"https:\/\/www.thermofisher.cn\/cn\/zh\/home\/industrial\/chromatography\/chromatography-learning-center\/liquid-chromatography-information\/hplc-system-components\/how-hplc-detectors-work\/charged-aerosol-detection.html\"><u>\u5e26\u7535\u6c14\u6eb6\u80f6\u68c0\u6d4b\uff08CAD\uff09<\/u><\/a>\u4ee5\u4fbf\u5728\u4e00\u6b21\u8fd0\u884c\u4e2d\u5145\u5206\u53d1\u6325\u60a8\u7684\u5206\u6790\u80fd\u529b\u3002<\/p>\n\n\n\n<p>\u65f6\u95f4\u662f\u4eba\u751f\u6700\u5b9d\u8d35\u7684\u8d44\u4ea7\uff0c\u6240\u4ee5\u4e3a\u4ec0\u4e48\u4e0d\u4ece\u4e00\u5f00\u59cb\u5c31\u4e3a\u6210\u529f\u505a\u597d\u51c6\u5907\u5462\uff1f<\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u805a\u5c71\u68a8\u916f\uff08PS\uff09\u662f\u4e00\u7c7b\u4e24\u6027\u975e\u79bb\u5b50\u8868\u9762\u6d3b\u6027\u5242\uff0c\u88ab\u7528\u4f5c\u4e73\u5316\u5242\u3001\u7a33\u5b9a\u5242\u548c\u589e\u6eb6\u5242\uff0c\u5e7f\u6cdb\u5e94\u7528\u4e8e\u5236\u836f\u548c\u751f\u7269\u5236\u836f\u914d\u65b9\u3001\u98df\u54c1\u751a<\/p>\n","protected":false},"author":1852,"featured_media":749,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_monsterinsights_skip_tracking":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[49],"tags":[],"division":[50],"class_list":{"0":"post-748","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-49","8":"division-cmd","9":"entry"},"_selected_authors":[1475],"_selected_reviewers":[],"acf":[],"yoast_head":"<!-- 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