{"id":754,"date":"2026-03-11T05:20:25","date_gmt":"2026-03-11T05:20:25","guid":{"rendered":"https:\/\/www.thermofisher.com\/blog\/accelerating-science-in-china\/?p=754"},"modified":"2026-03-11T05:20:26","modified_gmt":"2026-03-11T05:20:26","slug":"cryo-tem-of-lnps-lipid-nanoparticles-for-drug-delivery","status":"publish","type":"post","link":"https:\/\/www.thermofisher.cn\/blog\/cryo-tem-of-lnps-lipid-nanoparticles-for-drug-delivery\/","title":{"rendered":"\u51b7\u51bb\u900f\u5c04\u7535\u955c\u5f00\u542f\u4e86\u8102\u8d28\u7eb3\u7c73\u9897\u7c92(LNPs)\u5728\u836f\u7269\u9012\u9001\u65b9\u9762\u7684\u6f5c\u529b"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\" id=\"h-\u836f\u7269\u5f00\u53d1\u4e2d\u7684\u8102\u8d28\u7eb3\u7c73\u9897\u7c92\"><strong><strong>\u836f\u7269\u5f00\u53d1\u4e2d\u7684\u8102\u8d28\u7eb3\u7c73\u9897\u7c92<\/strong><\/strong><\/h2>\n\n\n\n<p>\u8102\u8d28\u7eb3\u7c73\u9897\u7c92\uff08LNPs\uff09\u5df2\u6210\u4e3a\u6838\u9178\u7c7b\u6cbb\u7597\u5242\u548c\u75ab\u82d7\u7684\u6709\u524d\u666f\u7684\u8f7d\u4f53\u3002\u5b83\u4eec\u7684\u8bbe\u8ba1\u548c\u5e94\u7528\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u4f9d\u8d56\u4e8e\u7ed3\u6784\u548c\u5f62\u6001\u7279\u6027\uff0c\u8fd9\u4e9b\u7279\u6027\u76f4\u63a5\u5f71\u54cd\u5176\u529f\u80fd\u3001\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u5168\u9762\u7684\u8868\u5f81\u5bf9\u4e8e\u8bbe\u8ba1\u9ad8\u6548\u7684\u8102\u8d28\u7eb3\u7c73\u9897\u7c92\u914d\u65b9\u81f3\u5173\u91cd\u8981\u3002\u5728\u672c\u535a\u5ba2\u4e2d\uff0c\u6211\u4eec\u5c06\u63a2\u8ba8\u8fd9\u79cd\u8868\u5f81\u7684\u91cd\u8981\u6027\u4ee5\u53ca\u51b7\u51bb\u900f\u5c04\u7535\u5b50\u663e\u5fae\u955c\uff08cryo-TEM\uff09\u5728LNP\u8bc4\u4f30\u4e2d\u7684\u4f5c\u7528\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-\u51b7\u51bb\u900f\u5c04\u7535\u5b50\u663e\u5fae\u955c\u5728\u8102\u8d28\u7eb3\u7c73\u9897\u7c92\u8868\u5f81\u4e2d\u7684\u4f18\u52bf\"><strong><strong>\u51b7\u51bb\u900f\u5c04\u7535\u5b50\u663e\u5fae\u955c\u5728\u8102\u8d28\u7eb3\u7c73\u9897\u7c92\u8868\u5f81\u4e2d\u7684\u4f18\u52bf<\/strong><\/strong><\/h2>\n\n\n\n<p>\u4f20\u7edf\u5206\u6790\u6280\u672f\uff0c\u5982\u52a8\u6001\u5149\u6563\u5c04\uff08DLS\uff09\u548c\u7eb3\u7c73\u9897\u7c92\u8ddf\u8e2a\u5206\u6790\uff0c\u53ef\u4ee5\u5bf9LNPs\u7684\u5c3a\u5bf8\u548c\u5206\u5e03\u8fdb\u884c\u6574\u4f53\u6d4b\u91cf\uff0c\u4f46\u7f3a\u4e4f\u53ef\u89c6\u5316\u5355\u4e2a\u7eb3\u7c73\u9897\u7c92\u7ed3\u6784\u6240\u9700\u7684\u5206\u8fa8\u7387\u3002\u800c\u51b7\u51bb\u900f\u5c04\u7535\u5b50\u663e\u5fae\u955c\u5219\u5141\u8bb8\u7814\u7a76\u4eba\u5458\u76f4\u63a5\u89c2\u5bdf\u5904\u4e8e\u539f\u751f\u6c34\u5408\u72b6\u6001\u4e0b\u7684LNP\uff0c\u65e0\u9700\u67d3\u8272\u6216\u56fa\u5b9a\u3002\u8fd9\u79cd\u9ad8\u5206\u8fa8\u7387\u6210\u50cf\u80fd\u529b\u80fd\u591f\u5b9e\u73b0\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><em>\u7cbe\u786e\u7684\u5c3a\u5bf8\u4e0e\u5f62\u72b6\u5206\u6790<\/em>cryo-TEM\u80fd\u591f\u6355\u6349\u5355\u4e2aLNP\u7684\u8be6\u7ec6\u56fe\u50cf\uff0c\u63ed\u793a\u5f71\u54cd\u836f\u7269\u9012\u9001\u6027\u80fd\u7684\u7c92\u5f84\u5206\u5e03\u3001\u591a\u5206\u6563\u6027\u548c\u5f62\u6001\u5f02\u8d28\u6027\u3002<\/li>\n\n\n\n<li><em>\u5305\u5c01\u6548\u7387\u8bc4\u4f30\uff1a<\/em>cryo-TEM\u53ef\u4ee5\u63ed\u793aRNA\u5728LNP\u4e2d\u7684\u88c5\u8f7d\u548c\u5206\u5e03\u60c5\u51b5\uff0c\u4e3a\u914d\u65b9\u6548\u7387\u63d0\u4f9b\u5173\u952e\u4fe1\u606f\u3002<\/li>\n\n\n\n<li><em>\u63d0\u5347\u6279\u6b21\u95f4\u4e00\u81f4\u6027\uff1a<\/em>\u53ef\u901a\u8fc7cryo-TEM\u8bc4\u4f30\u5236\u9020\u5de5\u827a\u7684\u53d8\u5f02\u6027\uff0c\u6709\u52a9\u4e8e\u786e\u4fdd\u4ea7\u54c1\u7684\u53ef\u91cd\u590d\u6027\u548c\u8d28\u91cf\u3002<\/li>\n\n\n\n<li><em>\u7eb3\u7c73\u7ed3\u6784\u6d1e\u5bdf\uff1a<\/em>\u5bf9\u8102\u8d28\u76f8\u884c\u4e3a\u53caLNP\u5185\u90e8\u7ed3\u6784\u7684\u7406\u89e3\u6709\u52a9\u4e8e\u4f18\u5316\u914d\u65b9\u6761\u4ef6\uff0c\u63d0\u9ad8\u7a33\u5b9a\u6027\u548c\u7597\u6548\u3002<\/li>\n\n\n\n<li><em>\u5de5\u827a\u4f18\u5316\uff1a<\/em>\u6765\u81eacryo-TEM\u7684\u6d1e\u89c1\u80fd\u591f\u63a8\u52a8\u5fae\u6d41\u63a7\u6df7\u5408\u3001\u6324\u51fa\u7b49LNP\u5236\u9020\u6280\u672f\u7684\u6539\u8fdb\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u5229\u7528cryo-TEM\u8fdb\u884c\u65b0\u578b\u9897\u7c92\u8868\u5f81\u6b63\u5728\u63a8\u52a8\u6211\u4eec\u5bf9LNP\u7ed3\u6784\u7684\u7406\u89e3\uff0c\u8fd9\u5bf9\u4e8e\u4f18\u5316\u914d\u65b9\u3001\u63d0\u5347RNA\u9012\u9001\u6548\u7387\u4ee5\u53ca\u5f00\u53d1\u4e0b\u4e00\u4ee3\u7eb3\u7c73\u836f\u7269\u81f3\u5173\u91cd\u8981\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-\u7406\u89e3lnps\u7684\u7ed3\u6784-\u6d3b\u6027\u5173\u7cfb\"><strong><strong>\u7406\u89e3LNPs\u7684\u7ed3\u6784-\u6d3b\u6027\u5173\u7cfb<\/strong><\/strong><\/h2>\n\n\n\n<p>LNPs\u7684\u4f18\u5316\u4e3b\u8981\u96c6\u4e2d\u5728\u591a\u79cd\u53ef\u80fd\u63d0\u9ad8\u8f6c\u67d3\u6548\u7387\u7684\u7ec4\u5206\u4e0a\uff0c\u5305\u62ec\u53ef\u79bb\u5b50\u5316\u8102\u8d28\u3001\u8f85\u52a9\u8102\u8d28\u548cPEG-\u8102\u8d28\u3002\u7136\u800c\uff0c\u7279\u5b9a\u8102\u8d28\u7ed3\u6784\u5728LNP-\u5185\u4f53\u76f8\u4e92\u4f5c\u7528\u4ee5\u53caRNA\u9012\u9001\u81f3\u7ec6\u80de\u8d28\u4e2d\u7684\u4f5c\u7528\u4ecd\u672a\u88ab\u5b8c\u5168\u7406\u89e3\u3002<\/p>\n\n\n\n<p>\u4e3a\u4e86\u89e3\u51b3\u8fd9\u4e00\u95ee\u9898\uff0c\u5e03\u91cc\u65af\u6258\u5927\u5b66\u548c\u83b1\u987f\u5927\u5b66\u7684\u79d1\u5b66\u5bb6\u4eec\u91c7\u7528\u4e86\u7406\u6027\u8bbe\u8ba1\u7684\u65b9\u6cd5\uff0c\u5de5\u7a0b\u5316\u5177\u6709\u660e\u786e\u5b9a\u4e49\u8102\u8d28\u8d85\u7ed3\u6784\u7684LNPs\u30021\u901a\u8fc7\u4f7f\u7528\u51b7\u51bb\u7535\u5b50\u65ad\u5c42\u626b\u63cf\uff08cryo-ET\uff09\u7b49\u5148\u8fdb\u6210\u50cf\u6280\u672f\uff0c\u4ed6\u4eec\u53d1\u73b0LNPs\u53ef\u4ee5\u5448\u73b0\u51fa\u4e0d\u540c\u7684\u5185\u90e8\u7ed3\u6784\uff0c\u5305\u62ec\u5c42\u72b6\u3001\u6db2\u6676\u53cd\u516d\u65b9\u76f8\u548c\u6df7\u5408\u8102\u8d28-RNA\u76f8\uff0c\u6bcf\u79cd\u7ed3\u6784\u90fd\u5728\u8f6c\u67d3\u6548\u7387\u4e2d\u8d77\u7740\u5173\u952e\u4f5c\u7528\uff08\u89c1\u56fe1\uff09\u3002\u8fd9\u79cd\u65b9\u6cd5\u8fd8\u80fd\u591f\u533a\u5206\u7a7a\u8f7dLNPs\u4e0e\u5305\u88f9siRNA\u7684LNPs\uff0c\u4e3aLNPs\u8bbe\u8ba1\u4f18\u5316\u53caRNA\u6cbb\u7597\u836f\u7269\u6539\u8fdb\u63d0\u4f9b\u4e86\u5173\u952e\u89c1\u89e3\uff08\u89c1\u56fe2\uff09\u3002<\/p>\n\n\n\n<p>\u8fd9\u9879\u7814\u7a76\u7a81\u663e\u4e86\u76f4\u63a5\u51b7\u51bb\u900f\u5c04\u7535\u955c\uff08cryo-TEM\uff09\u53ef\u89c6\u5316\u5728\u63a8\u8fdb\u6211\u4eec\u5bf9LNP\u7ed3\u6784-\u529f\u80fd\u5173\u7cfb\u7406\u89e3\u65b9\u9762\u7684\u91cd\u8981\u4f5c\u7528\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"http:\/\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2025\/05\/blog-5-fig-1-1024x281-1.jpg\" alt=\"Different LNPs visualized with cryo-TEM.\" class=\"wp-image-1706\" \/><figcaption class=\"wp-element-caption\">\u56fe1. \u5404\u79cd\u8102\u8d28\u7eb3\u7c73\u9897\u7c92\u5236\u5242\u7684\u4ee3\u8868\u6027\u51b7\u51bb\u900f\u5c04\u7535\u955c\uff08cryo-TEM\uff09\u56fe\u50cf\u3002\u9ed1\u8272\u7bad\u5934\u6807\u793a\u5c42\u72b6\u7ed3\u6784\uff0c\u767d\u8272\u7bad\u5934\u6307\u793a\u975e\u5c42\u72b6\u7ed3\u6784\u3002\u6bd4\u4f8b\u5c3a=100\u7eb3\u7c73\u3002\u56fe\u7247\u8f6c\u8f7d\u81ea<a href=\"https:\/\/doi.org\/10.1038\/s41467-024-45666-5\"><u>Pattipeiluhu \u7b49\u4eba\u3002<\/u><\/a>\u6839\u636e<a href=\"http:\/\/creativecommons.org\/licenses\/by\/4.0\/\"><u>CC BY 4.0\u534f\u8bae\u3002<\/u><\/a><\/figcaption><\/figure>\n\n\n<div class=\"wp-block-image size-full wp-image-1707\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"http:\/\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2025\/05\/blog-5-fig-2-1024x400-1.jpg\" alt=\"Lipid nanoparticles visualized with cryo electron tomography.\" class=\"wp-image-1707\" \/><figcaption class=\"wp-element-caption\">\u56fe2. \u7a7a\u8f7d\uff0849PE-LNP-noRNA\uff09\u548c\u5305\u8f7d\uff0849PE-LNP-NP1\uff09LNPs\u7684\u8d85\u5fae\u7ed3\u6784\u51b7\u51bb\u7535\u5b50\u65ad\u5c42\u5206\u6790\u3002\u6bd4\u4f8b\u5c3a=50\u7eb3\u7c73\u3002\u56fe\u7247\u8f6c\u8f7d\u81ea<a href=\"https:\/\/doi.org\/10.1038\/s41467-024-45666-5\"><u>Pattipeiluhu \u7b49\u4eba\u3002<\/u><\/a>\u6839\u636e<a href=\"http:\/\/creativecommons.org\/licenses\/by\/4.0\/\"><u>CC BY 4.0\u534f\u8bae\u3002<\/u><\/a><\/figcaption><\/figure>\n<\/div>\n\n\n<h2 class=\"wp-block-heading\" id=\"h-\u5e94\u5bf9\u5185\u4f53\u9003\u9038\u7684\u6311\u6218\"><strong><strong>\u5e94\u5bf9\u5185\u4f53\u9003\u9038\u7684\u6311\u6218<\/strong><\/strong><\/h2>\n\n\n\n<p>LNP mRNA\u590d\u5408\u7269\u6b63\u5728\u6539\u53d8\u9776\u5411\u6cbb\u7597\u7684\u9012\u9001\u65b9\u5f0f\uff0c\u4f46\u8bf8\u5982\u5185\u4f53\u9003\u9038\u6548\u7387\u4f4e\u3001\u9ad8\u6bd2\u6027\u548c\u7ec4\u7ec7\u4e2d\u6301\u7eed\u65f6\u95f4\u8fc7\u957f\u7b49\u95ee\u9898\u9650\u5236\u4e86\u5176\u5e94\u7528\u3002\u8fd1\u671f\uff0c\u5df2\u6709\u591a\u9879\u7814\u7a76\u63d0\u51fa\u4e86\u6539\u5584\u5185\u4f53\u9003\u9038\u7684\u89e3\u51b3\u65b9\u6848\u3002<\/p>\n\n\n\n<p>\u6df1\u5733\u65b0\u79d1\u7eb3\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\u7684\u4e00\u7ec4\u79d1\u5b66\u5bb6\u5f15\u5165\u4e86\u4e00\u79cd\u65b0\u578b\u9633\u79bb\u5b50\u805a\u5408\u7269\u80f6\u675f\uff08cPM\uff09\uff0c\u4e0eLNPs\u5171\u540c\u9012\u9001\uff0c\u7ed3\u679c\u663e\u793a\u80fd\u591f\u6539\u5584\u5185\u4f53\u9003\u9038\u5e76\u63d0\u9ad8\u4f53\u5185mRNA\u8868\u8fbe\uff0c\u540c\u65f6\u4e0d\u6539\u53d8LNPs\u7684\u6027\u8d28\u30022\u51b7\u51bb\u900f\u5c04\u7535\u5b50\u663e\u5fae\u955c\uff08cryo-TEM\uff09\u5728\u786e\u8ba4cPM\u548cLNP\u7ed3\u6784\u5b8c\u6574\u6027\u65b9\u9762\u53d1\u6325\u4e86\u91cd\u8981\u4f5c\u7528\uff0c\u63d0\u4f9b\u4e86\u5173\u4e8e\u7eb3\u7c73\u9897\u7c92\u5f62\u6001\u3001\u5c3a\u5bf8\u5206\u5e03\u548c\u8868\u9762\u7279\u5f81\u7684\u8be6\u7ec6\u89c1\u89e3\uff08\u56fe3\uff09\u3002\u56fe\u50cf\u663e\u793acPM\u5448\u8fd1\u7403\u5f62\u4e14\u8868\u9762\u7c97\u7cd9\uff0c\u5176\u9897\u7c92\u5c3a\u5bf8\u6bd4\u52a8\u6001\u5149\u6563\u5c04\uff08DLS\uff09\u6d4b\u91cf\u503c\u66f4\u5c0f\u3002\u8fd9\u79cd\u5dee\u5f02\u5f88\u53ef\u80fd\u662f\u7531\u4e8e\u6eb6\u6db2\u4e2dcPM\u53d1\u751f\u805a\u96c6\uff0c\u800ccryo-TEM\u901a\u8fc7\u5728\u73bb\u7483\u5316\u72b6\u6001\u4e0b\u5bf9\u5355\u4e2a\u9897\u7c92\u8fdb\u884c\u6210\u50cf\uff0c\u4ece\u800c\u83b7\u5f97\u66f4\u51c6\u786e\u7684\u9897\u7c92\u5c3a\u5bf8\u3002\u8fd9\u79cd\u7cbe\u786e\u6027\u5bf9\u4e8e\u9a8c\u8bc1\u914d\u65b9\u7684\u8d28\u91cf\u548c\u4e00\u81f4\u6027\u81f3\u5173\u91cd\u8981\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image alignnone wp-image-1708 size-full\"><img decoding=\"async\" src=\"http:\/\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2025\/05\/blog-5-fig-3-1024x373-1.jpg\" alt=\"Cryo-TEM of cPM micelles and LNPs.\" class=\"wp-image-1708\" \/><figcaption class=\"wp-element-caption\">\u56fe3. \u4ee3\u8868\u6027\u7684cPM\u80f6\u675f\u51b7\u51bb\u900f\u5c04\u7535\u5b50\u663e\u5fae\u955c\u56fe\u50cf\uff0c\u663e\u793a\u5176\u8868\u9762\u7c97\u7cd9\uff0c\u4ee5\u53ca\u4e24\u79cdLNP\u914d\u65b9\u8868\u73b0\u51fa\u660e\u786e\u7403\u5f62\u5f62\u6001\u3002\u6bd4\u4f8b\u5c3a=50\u7eb3\u7c73\u3002\u56fe\u7247\u8f6c\u8f7d\u81ea<a href=\"https:\/\/doi.org\/10.3390\/vaccines13010025\"><u>\u9093\u7b49\u4eba\u3002<\/u><\/a>\u6839\u636e<a href=\"http:\/\/creativecommons.org\/licenses\/by\/4.0\/\"><u>CC BY 4.0\u534f\u8bae\u3002<\/u><\/a><\/figcaption><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-\u63a8\u8fdblnp\u5236\u9020\u7684\u7cbe\u786e\u9897\u7c92\u8868\u5f81\"><strong><strong>\u63a8\u8fdbLNP\u5236\u9020\u7684\u7cbe\u786e\u9897\u7c92\u8868\u5f81<\/strong><\/strong><\/h2>\n\n\n\n<p>\u5728\u7eb3\u7c73\u533b\u5b66\u9886\u57df\uff0c\u5f00\u53d1\u53ef\u6269\u5c55\u4e14\u53ef\u91cd\u590d\u7684\u8102\u8d28\u7eb3\u7c73\u9897\u7c92\uff08LNP\uff09\u751f\u4ea7\u65b9\u6cd5\u662f\u4e00\u9879\u91cd\u5927\u6311\u6218\u3002\u5229\u7528\u51b7\u51bb\u900f\u5c04\u7535\u5b50\u663e\u5fae\u955c\uff08cryo-TEM\uff09\u5bf9\u5355\u4e2aLNP\u9897\u7c92\u8fdb\u884c\u53ef\u89c6\u5316\u5df2\u88ab\u8bc1\u660e\u81f3\u5173\u91cd\u8981\uff0c\u4f7f\u7814\u7a76\u4eba\u5458\u80fd\u591f\u4ee5\u6781\u9ad8\u7684\u7ec6\u8282\u548c\u7cbe\u5ea6\u4ed4\u7ec6\u6bd4\u8f83\u5404\u79cd\u5236\u9020\u65b9\u6cd5\u548c\u6280\u672f\uff0c\u4ece\u800c\u4fc3\u8fdbLNP\u751f\u4ea7\u5de5\u827a\u7684\u4f18\u5316\u3002<\/p>\n\n\n\n<p>\u83b1\u987f\u5927\u5b66\u548c\u7ea6\u7ff0\u5185\u65af\u00b7\u53e4\u817e\u5821\u5927\u5b66\u7684\u79d1\u5b66\u5bb6\u6700\u8fd1\u63a8\u51fa\u4e86\u4e00\u79cd\u5177\u6709\u6210\u672c\u6548\u76ca\u7684\u5fae\u6d41\u63a7\u5e73\u53f0CD\uff0c\u7528\u4e8e\u5408\u6210mRNA LNP\uff0c\u8be5\u5e73\u53f0\u5141\u8bb8\u5728\u4e0d\u5f71\u54cd\u8d28\u91cf\u7684\u60c5\u51b5\u4e0b\u8fdb\u884c\u7cbe\u786e\u8c03\u6574\u30023\u5bf9\u8fd9\u4e9bmRNA LNP\u8fdb\u884c\u51b7\u51bb\u7535\u955c\u5206\u6790\u663e\u793a\uff0c\u5fae\u6d41\u63a7\u6cd5\u5236\u5907\u7684LNP\u66f4\u5c0f\u3001\u66f4\u5747\u4e00\uff0c\u5e76\u5177\u6709\u6709\u5e8f\u7684\u7535\u5b50\u81f4\u5bc6\u6838\u5fc3\u3002\u7f13\u51b2\u6db2\u548c\u79bb\u5b50\u5f3a\u5ea6\u5f71\u54cd\u56ca\u6ce1\u5f62\u6210\u548c\u8f6c\u67d3\u6548\u7387\uff0c\u800cPEG-\u8102\u8d28\u6d53\u5ea6\u5219\u5f71\u54cd\u9897\u7c92\u5927\u5c0f\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-\u764c\u75c7\u6cbb\u7597\u4e0e\u86cb\u767d\u66ff\u4ee3\u7597\u6cd5\u7684\u65b0\u578b\u6cbb\u7597\u65b9\u6cd5\"><strong><strong>\u764c\u75c7\u6cbb\u7597\u4e0e\u86cb\u767d\u66ff\u4ee3\u7597\u6cd5\u7684\u65b0\u578b\u6cbb\u7597\u65b9\u6cd5<\/strong><\/strong><\/h2>\n\n\n\n<p>mRNA\u75ab\u82d7\u7684\u5feb\u901f\u6210\u529f\u4f7fLNP\u6210\u4e3a\u6838\u9178\u9012\u9001\u7684\u91cd\u8981\u8f7d\u4f53\u3002LNP\u4e5f\u6b63\u5728\u88ab\u63a2\u7d22\u7528\u4e8e\u764c\u75c7\u548c\u4ee3\u8c22\u6027\u75be\u75c5\u7684\u9776\u5411\u6cbb\u7597\uff0c\u8fd9\u9700\u8981\u9488\u5bf9\u53cd\u590d\u7ed9\u836f\u5e76\u5177\u6700\u5c0f\u514d\u75ab\u539f\u6027\u7684\u914d\u65b9\u8fdb\u884c\u4f18\u5316\u3002<\/p>\n\n\n\n<p>\u897f\u5948\u5c71\u4f0a\u574e\u533b\u5b66\u9662\u7684\u7814\u7a76\u4eba\u5458\u5f00\u53d1\u4e86\u4e00\u79cd\u65b0\u578bLNP-RNA\u6297\u539f\u5448\u9012\u5e73\u53f0\uff0c\u53ef\u91cd\u65b0\u5229\u7528SARS-CoV-2\u75ab\u82d7\u8bf1\u5bfc\u7684T\u7ec6\u80de\u514d\u75ab\u6765\u9776\u5411\u764c\u75c7\u30024\u901a\u8fc7\u8bbe\u8ba1\u4e00\u7cfb\u5217\u6c28\u57fa\u9178\u548c\u6c28\u57fa\u9187\u884d\u751f\u53ef\u79bb\u5b50\u5316\u8102\u8d28\uff08AA\u8102\u8d28\uff09\uff0c\u4ed6\u4eec\u80fd\u591f\u5236\u5907\u51fa\u80fd\u9ad8\u6548\u76f4\u63a5\u9012\u9001\u81f3\u80bf\u7624\u90e8\u4f4d\u7684LNP\u914d\u65b9\u3002\u51b7\u51bb\u7535\u955c\u5728\u53ef\u89c6\u5316\u8fd9\u4e9b\u5de5\u7a0b\u5316LNP\u7ed3\u6784\u5b8c\u6574\u6027\u3001\u5f62\u6001\u53ca\u5305\u5c01\u6548\u7387\u65b9\u9762\u53d1\u6325\u4e86\u5173\u952e\u4f5c\u7528\u3002<\/p>\n\n\n\n<p>\u5728\u53e6\u4e00\u9879\u7814\u7a76\u4e2d\uff0c\u7ea6\u7ff0\u5185\u65af\u00b7\u53e4\u817e\u5821\u5927\u5b66\u4e0e\u9a6c\u514b\u65af\u00b7\u666e\u6717\u514b\u805a\u5408\u7269\u7814\u7a76\u6240\u7684\u79d1\u5b66\u5bb6\u4eec\u8003\u5bdf\u4e86LNP\u7ec4\u6210\u5982\u4f55\u5f71\u54cdmRNA\u5305\u5c01\u3001\u7a33\u5b9a\u6027\u3001\u514d\u75ab\u53cd\u5e94\u53ca\u4f53\u5185\u5206\u5e03\u30025\u51b7\u51bb\u900f\u5c04\u7535\u5b50\u663e\u5fae\u955c\uff08Cryo-TEM\uff09\u663e\u793a\uff0c\u6539\u53d8\u5355\u4e2aLNP\u7ec4\u5206\u4f1a\u5bfc\u81f4\u4e0d\u540c\u7684\u7ed3\u6676\u8d85\u5fae\u7ed3\u6784\uff0c\u5305\u62ec\u53cc\u5c42\u7ed3\u6784\u3001\u201c\u56ca\u6ce1\u201d\u548c\u591a\u5c42\u9897\u7c92\uff0c\u8fd9\u4e9b\u7ed3\u6784\u76f4\u63a5\u5f71\u54cdLNP\u7684\u529f\u80fd\u548c\u7a33\u5b9a\u6027\uff08\u56fe4\uff09\u3002<\/p>\n\n\n<div class=\"wp-block-image size-full wp-image-1710\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"http:\/\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2025\/05\/blog-5-fig-4-1024x682-1.jpg\" alt=\"Cryo-TEM visualization of lipid nanoparticles.\" class=\"wp-image-1710\" \/><figcaption class=\"wp-element-caption\">\u56fe4. \u5404\u79cdLNP\u914d\u65b9\u7684\u51b7\u51bb\u900f\u5c04\u7535\u5b50\u663e\u5fae\u955c\u56fe\u7247\uff0c\u7bad\u5934\u7a81\u51fa\u663e\u793a\u4e86\u7279\u5b9a\u7684\u7ed3\u6784\u7279\u5f81\u548c\u5f02\u5e38\uff0c\u5305\u62ec\u201c\u56ca\u6ce1\u201d\uff08\u7eff\u8272\u7bad\u5934\uff09\u548c\u5185\u90e8\u7f3a\u9677\uff08\u84dd\u8272\u7bad\u5934\uff09\u3002<\/figcaption><\/figure>\n<\/div>\n\n\n<h2 class=\"wp-block-heading\" id=\"h-\u7ed3\u8bba\"><strong><strong>\u7ed3\u8bba<\/strong><\/strong><\/h2>\n\n\n\n<p>LNP\u662f\u4e00\u79cd\u590d\u6742\u4f53\u7cfb\uff0c\u4e0d\u540c\u7c7b\u578b\u7684\u6838\u9178\u8f7d\u4f53\u548c\u8102\u8d28\u4fee\u9970\u53ef\u4ee5\u521b\u9020\u5177\u6709\u4e0d\u540c\u7279\u6027\u7684LNP\u3002\u51b7\u51bb\u900f\u5c04\u7535\u5b50\u663e\u5fae\u955c\u80fd\u591f\u5728\u9897\u7c92\u6c34\u5e73\u5206\u6790LNP\uff0c\u56e0\u6b64\u5bf9\u4e8e\u5176\u5f00\u53d1\u548c\u8868\u5f81\u81f3\u5173\u91cd\u8981\u3002<\/p>\n\n\n\n<p>\u968f\u7740\u5bf9\u57fa\u4e8e\u7eb3\u7c73\u9897\u7c92\u836f\u7269\u9012\u9001\u7cfb\u7edf\u76d1\u7ba1\u529b\u5ea6\u7684\u4e0d\u65ad\u52a0\u5f3a\uff0c\u51b7\u51bb\u900f\u5c04\u7535\u5b50\u663e\u5fae\u955c\u5df2\u6210\u4e3a\u51c6\u786e\u8bc4\u4f30\u5173\u952e\u8d28\u91cf\u5c5e\u6027\u7684\u91cd\u8981\u5de5\u5177\u3002\u81ea\u52a8\u5316\u56fe\u50cf\u5904\u7406\u3001\u673a\u5668\u5b66\u4e60\u4ee5\u53ca\u76f8\u5173\u663e\u5fae\u6280\u672f\u7684\u53d1\u5c55\uff0c\u5e76\u7ed3\u5408\u5982Thermo Scientific Amira\u8f6f\u4ef6\u7b49\u7efc\u5408\u8f6f\u4ef6\u89e3\u51b3\u65b9\u6848\uff0c\u8fdb\u4e00\u6b65\u63d0\u5347\u4e86\u51b7\u51bb\u900f\u5c04\u7535\u5b50\u663e\u5fae\u955c\u5728\u4f18\u5316LNP\u65b9\u9762\u7684\u4f5c\u7528\uff0c\u6709\u52a9\u4e8e\u786e\u4fdd\u66f4\u5b89\u5168\u3001\u66f4\u6709\u6548\u6cbb\u7597\u836f\u7269\u7684\u5f00\u53d1\u3002<\/p>\n\n\n\n<p><strong><strong>\u53c2\u8003\u6587\u732e<\/strong><\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Pattipeiluhu, R,<em> et al.<\/em><strong>Liquid crystalline inverted lipid phases encapsulating siRNA enhance lipid nanoparticle mediated transfection.<\/strong>&nbsp;<em>Nat Commun<\/em>&nbsp;15, 1303 (2024). doi: <a href=\"https:\/\/doi.org\/10.1038\/s41467-024-45666-5\" target=\"_blank\" rel=\"noopener\">1038\/s41467-024-45666-5<\/a><\/li>\n\n\n\n<li>Deng, S, <em>et al. <\/em><strong>Development of a Cationic Polymeric Micellar Structure with Endosomal Escape Capability Enables Enhanced Intramuscular Transfection of mRNA-LNPs.&nbsp;<\/strong><em>Vaccines<\/em>13:25 (2025). doi: <a href=\"https:\/\/doi.org\/10.3390\/vaccines13010025\" target=\"_blank\" rel=\"noopener\">3390\/vaccines13010025<\/a><\/li>\n\n\n\n<li>Johnson, NV, <em>et al.<\/em> <strong>On the Influence of Fabrication Methods and Materials for mRNA-LNP Production: From Size and Morphology to Internal Structure and mRNA Delivery Performance In Vitro and In Vivo.<\/strong> <em>Adv Healthc Mater<\/em> 13:26 (2024). doi: <a href=\"https:\/\/doi.org\/10.1002\/adhm.202401252\" target=\"_blank\" rel=\"noopener\">1002\/adhm.202401252<\/a><\/li>\n\n\n\n<li>Xue, Y, <em>et al. <\/em><strong>LNP-RNA-mediated antigen presentation leverages SARS-CoV-2-specific immunity for cancer treatment.<\/strong>&nbsp;<em>Nat Commun<\/em>&nbsp;16:2198 (2025). doi: <a href=\"https:\/\/doi.org\/10.1038\/s41467-025-57149-2\" target=\"_blank\" rel=\"noopener\">1038\/s41467-025-57149-2<\/a><\/li>\n\n\n\n<li>Gambaro, R, <em>et al.<\/em> <strong>Optimizing mRNA-Loaded Lipid Nanoparticles as a Potential Tool for Protein-Replacement Therapy.<\/strong><em>Pharmaceutics<\/em>&nbsp;16:771 (2024). doi: <a href=\"https:\/\/doi.org\/10.3390\/pharmaceutics16060771\" target=\"_blank\" rel=\"noopener\">3390\/pharmaceutics16060771<\/a><\/li>\n<\/ol>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/www.thermofisher.cn\/cn\/zh\/home\/support\/contact-us-cn.html?icid=blog_banner#form\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"176\" src=\"http:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/02\/779-\u00d7-134-x3-1-1024x176.jpg\" alt=\"contact and techincal support\" class=\"wp-image-387\" srcset=\"https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/02\/779-\u00d7-134-x3-1-1024x176.jpg 1024w, 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