{"id":988,"date":"2026-03-19T05:07:21","date_gmt":"2026-03-19T05:07:21","guid":{"rendered":"https:\/\/www.thermofisher.com\/blog\/accelerating-science-in-china\/?p=988"},"modified":"2026-04-22T21:59:30","modified_gmt":"2026-04-22T21:59:30","slug":"fluorescently-labeled-lipoproteins","status":"publish","type":"post","link":"https:\/\/www.thermofisher.cn\/blog\/fluorescently-labeled-lipoproteins\/","title":{"rendered":"\u8102\u8d28\u4ee3\u8c22\u7814\u7a76\u5173\u952e\u5de5\u5177\u201c\u8367\u5149\u6807\u8bb0\u8102\u86cb\u767d\u201d\u8be6\u89e3"},"content":{"rendered":"\n

\u7531\u4e8e\u8102\u8d28\u4ee3\u8c22\u5728\u5404\u79cd\u75be\u75c5\u4e2d\u7684\u91cd\u8981\u4f5c\u7528\uff0c\u5b83\u662f\u836f\u7269\u53d1\u73b0\u7684\u5173\u952e\u76ee\u6807\u3002\u901a\u8fc7\u8c03\u8282\u8102\u8d28\u5408\u6210\u3001\u50a8\u5b58\u548c\u5206\u89e3\uff0c\u9776\u5411\u8102\u8d28\u4ee3\u8c22\u53ef\u4ee5\u5e2e\u52a9\u7ba1\u7406\u80a5\u80d6\u3001\u7cd6\u5c3f\u75c5\u548c\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7b49\u4ee3\u8c22\u6027\u75be\u75c5\u3002\u5b83\u8fd8\u53ef\u4ee5\u901a\u8fc7\u6291\u5236\u80bf\u7624\u751f\u957f\u548c\u514b\u670d\u836f\u7269\u8010\u836f\u6027\u7528\u4e8e\u764c\u75c7\u6cbb\u7597\u3002\u6b64\u5916\uff0c\u9776\u5411\u8102\u8d28\u4ee3\u8c22\u901a\u8def\u63d0\u4f9b\u4e86\u6cbb\u7597\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\u548c\u708e\u75c7\u6027\u75be\u75c5\u7684\u6f5c\u5728\u65b9\u6cd5\u3002<\/p>\n\n\n\n

LDL\u5728\u8102\u8d28\u4ee3\u8c22\u836f\u7269\u5f00\u53d1\u4e2d\u7684\u91cd\u8981\u6027<\/strong><\/h2>\n\n\n\n

\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\uff08LDL\uff09\u662f\u8840\u6db2\u4e2d\u80c6\u56fa\u9187\u7684\u4e3b\u8981\u8f7d\u4f53\u3002\u5b83\u5c06\u80c6\u56fa\u9187\u8fd0\u8f93\u5230\u7ec4\u7ec7\uff0c\u5bf9\u4e8e\u7ec6\u80de\u819c\u7ed3\u6784\u548c\u6fc0\u7d20\u5408\u6210\u81f3\u5173\u91cd\u8981\u3002\u7136\u800c\uff0c\u8fc7\u591a\u7684LDL\u80c6\u56fa\u9187\u4f1a\u5bfc\u81f4\u52a8\u8109\u4e2d\u5f62\u6210\u6591\u5757\uff0c\u5bfc\u81f4\u52a8\u8109\u7ca5\u6837\u786c\u5316\u548c\u5fc3\u8840\u7ba1\u75be\u75c5\u3002\u56e0\u6b64LDL\u4e00\u76f4\u662f\u836f\u7269\u53d1\u73b0\u7684\u91cd\u8981\u76ee\u6807\uff0c\u6bd4\u5982\uff1a<\/p>\n\n\n\n

    \n
  1. \u4ed6\u6c40\u7c7b\u836f\u7269\uff1a<\/strong>\u8fd9\u4e9b\u836f\u7269\u6291\u5236HMG-CoA\u8fd8\u539f\u9176\uff0c\u8fd9\u662f\u4e00\u79cd\u80c6\u56fa\u9187\u5408\u6210\u7684\u5173\u952e\u9176\uff0c\u4ece\u800c\u964d\u4f4eLDL-Cholesterol\uff08LDL-C\uff09\u6c34\u5e73\u3002<\/li>\n\n\n\n
  2. PCSK9\u6291\u5236\u5242\uff1a<\/strong>PCSK9\u662f\u4e00\u79cd\u964d\u89e3\u809d\u7ec6\u80de\u4e0aLDL\u53d7\u4f53\u7684\u86cb\u767d\u8d28\u3002\u6291\u5236PCSK9\u53ef\u4ee5\u589e\u52a0LDL\u53d7\u4f53\u7684\u6570\u91cf\uff0c\u589e\u5f3aLDL-C\u4ece\u8840\u6db2\u4e2d\u7684\u6e05\u9664\u3002<\/li>\n\n\n\n
  3. \u4f9d\u6298\u9ea6\u5e03 (Ezetimibe)\uff1a<\/strong>\u8fd9\u79cd\u836f\u7269\u6291\u5236\u5c0f\u80a0\u5bf9\u80c6\u56fa\u9187\u7684\u5438\u6536\uff0c\u4ece\u800c\u964d\u4f4e\u8840\u6db2\u4e2d\u7684LDL-C\u6c34\u5e73\u3002<\/li>\n<\/ol>\n\n\n\n

    \u6b63\u5728\u8fdb\u884c\u4e2d\u7684\u7814\u7a76\u96c6\u4e2d\u5728\u5bfb\u627e\u65b0\u7684\u548c\u66f4\u6709\u6548\u7684\u65b9\u6cd5\u6765\u7ba1\u7406LDL\u6c34\u5e73\u3002\u8fd9\u5305\u62ec\u5f00\u53d1\u5c0f\u5206\u5b50\u6291\u5236\u5242\u3001\u5355\u514b\u9686\u6297\u4f53\u548c\u57fa\u4e8eRNA\u7684\u6cbb\u7597\u65b9\u6cd5\uff0c\u8fd9\u4e9b\u65b9\u6cd5\u9776\u5411LDL\u4ee3\u8c22\u53ca\u5176\u8c03\u8282\u7684\u5404\u4e2a\u65b9\u9762\u3002<\/p>\n\n\n\n

    \u4eca\u5929\u6211\u4eec\u5c06\u805a\u7126\u8102\u8d28\u4ee3\u8c22\u7814\u7a76\u5173\u952e\u5de5\u5177\u201c\u8367\u5149\u6807\u8bb0\u8102\u86cb\u767d\u201d\uff0c\u8fdb\u884c\u6df1\u5165\u89e3\u6790\u3002<\/strong><\/p>\n\n\n\n

    01 \u8102\u86cb\u767d\u79cd\u7c7b\uff08Lipoproteins\uff09<\/strong><\/h3>\n\n\n\n

    \u8840\u6d46\u4e2d\u542b\u6709\u5927\u91cf\u7684\u8102\u7c7b\u7269\u8d28\uff0c\u800c\u8102\u7c7b\u4e0d\u6eb6\u4e8e\u6c34\u3002\u8fd9\u4e9b\u8102\u7c7b\u4f1a\u4e0e\u8f7d\u8102\u86cb\u767d\u7ed3\u5408\uff0c\u5f62\u6210\u53ef\u6eb6\u6027\u8102\u86cb\u767d\uff08Lipoproteins\uff09\u5b58\u5728\u4e8e\u8840\u6d46\u4e2d\uff0c\u968f\u540e\u8102\u86cb\u767d\u4f1a\u968f\u7740\u8840\u6db2\u5faa\u73af\u5230\u5168\u8eab\u5404\u5904\u7684\u7ec6\u80de\u53c2\u4e0e\u8102\u8d28\u4ee3\u8c22\u3002\u8102\u86cb\u767d\u7684\u7ed3\u6784\u901a\u5e38\u7531\u4e09\u90e8\u5206\u7ec4\u6210\uff1a\u8868\u9762\u662f\u7531\u78f7\u8102\u3001\u6e38\u79bb\u80c6\u56fa\u9187\u7ec4\u6210\u7684\u5355\u5c42\u819c\uff0c\u5355\u5c42\u819c\u4e0a\u540c\u65f6\u4f1a\u7ed3\u5408\u7279\u5b9a\u8f7d\u8102\u86cb\u767d\uff0c\u4ee5\u53ca\u5355\u5c42\u819c\u5185\u5305\u56f4\u7740\u4e00\u4e2a\u7531\u975e\u6781\u6027\u8102\u8d28\uff08\u4e3b\u8981\u662f\u80c6\u56fa\u9187\u916f\u548c\u7518\u6cb9\u4e09\u916f\uff09\u7ec4\u6210\u7684\u758f\u6c34\u6838\u5fc3\uff08\u56fe1\uff09\u3002<\/p>\n\n\n\n

    \"\"<\/figure>\n\n\n\n

    \u56fe1.\u8102\u86cb\u767d\u7ed3\u6784[1]<\/sup><\/p>\n\n\n\n

    \u8102\u86cb\u767d\u7684\u8102\u7c7b\u6bd4\u4f8b\u3001\u8f7d\u8102\u86cb\u767d\u79cd\u7c7b\u4e0d\u540c\uff0c\u5bfc\u81f4\u5176\u5404\u81ea\u7406\u5316\u6027\u8d28\u4e5f\u4e0d\u5c3d\u76f8\u540c\u3002\u6839\u636e\u8d85\u901f\u79bb\u5fc3\u6cd5\uff0c\u6309\u7167\u8102\u86cb\u767d\u9897\u7c92\u5bc6\u5ea6\u5927\u5c0f\u5dee\u5f02\uff0c\u5206\u4e3a\u4e73\u7cdc\u5fae\u7c92\uff08Chylomicrons\uff0cCM\uff09\u3001\u6781\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\uff08Very low density lipoprotein\uff0cVLDL\uff09\u3001\u4e2d\u95f4\u5bc6\u5ea6\u8102\u86cb\u767d\uff08Intermediate density lipoprotein\uff0cIDL\uff09\u3001\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\uff08Low density lipoprotein\uff0cLDL\uff09\u3001\u9ad8\u5bc6\u5ea6\u8102\u86cb\u767d\uff08High density lipoprotein\uff0cHDL\uff09\uff0c\u5982\u4ee5\u4e0b\u8868\u683c\u6240\u793a\u3002<\/p>\n\n\n\n

    Lipoprotein<\/td>Density (g\/ml)<\/td>Size (nm)<\/td>Major Lipids<\/td><\/tr>
    Chylomicrons<\/td><0.930<\/td>75-1200<\/td>Triglycerides<\/td><\/tr>
    VLDL<\/td>0.930- 1.006<\/td>30-80<\/td>Triglycerides<\/td><\/tr>
    IDL<\/td>1.006- 1.019<\/td>25-35<\/td>Triglycerides Cholesterol<\/td><\/tr>
    LDL<\/td>1.019-1.063<\/td>18-25<\/td>Cholesterol<\/td><\/tr>
    HDL<\/td>1.063- 1.210<\/td>5-12<\/td>Cholesterol Phospholipids<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

    02 \u5929\u7136\u8102\u86cb\u767d<\/strong><\/h3>\n\n\n\n

    \u4e0d\u540c\u8102\u86cb\u767d\uff0c\u8d1f\u8d23\u4e0d\u540c\u7684\u4ee3\u8c22\u529f\u80fd\u3002\u5185\u6e90\u6027\u8102\u86cb\u767d\u9014\u5f84\u59cb\u4e8e\u809d\u810f\u4e2dVLDL\u7684\u5f62\u6210\u3002VLDL\u4e2d\u643a\u5e26\u7684\u7518\u6cb9\u4e09\u916f\u5728\u808c\u8089\u548c\u8102\u80aa\u7ec4\u7ec7\u4e2d\u88ab\u8102\u86cb\u767d\u8102\u80aa\u9176\u4ee3\u8c22\uff0c\u91ca\u653e\u6e38\u79bb\u8102\u80aa\u9178\uff0c\u5f62\u6210IDL\u3002IDL\u8fdb\u4e00\u6b65\u4ee3\u8c22\u4e3aLDL\uff0cLDL\u88ab\u8bb8\u591a\u7ec4\u7ec7\uff08\u5305\u62ec\u809d\u810f\uff0c\u5176\u662f\u4e3b\u8981\u7684\u6444\u53d6\u90e8\u4f4d\uff09\u7684LDL\u53d7\u4f53\u5438\u6536\u3002\u80c6\u56fa\u9187\u7684\u9006\u5411\u8f6c\u8fd0\u59cb\u4e8e\u809d\u810f\u548c\u80a0\u9053\u5f62\u6210\u65b0\u751fHDL\u3002\u8fd9\u4e9b\u5c0f\u7684HDL\u9897\u7c92\u968f\u540e\u53ef\u4ee5\u5438\u6536\u4ece\u7ec6\u80de\u4e2d\u6d41\u51fa\u7684\u80c6\u56fa\u9187\u548c\u78f7\u8102\uff0c\u6700\u7ec8\u5f62\u6210\u6210\u719f\u7684HDL\u3002\u6210\u719f\u7684HDL\u53ef\u4ee5\u4ece\u7ec6\u80de\u4e2d\u83b7\u53d6\u989d\u5916\u7684\u80c6\u56fa\u9187\u3002\u7136\u540e\uff0cHDL\u5c06\u80c6\u56fa\u9187\u8f6c\u8fd0\u81f3\u809d\u810f\uff0c\u76f4\u63a5\u6216\u95f4\u63a5\u5730\u5c06\u80c6\u56fa\u9187\u8f6c\u79fb\u5230VLDL\u6216LDL\u3002[1]<\/sup>\u80c6\u56fa\u9187\u4ece\u5de8\u566c\u7ec6\u80de\u6d41\u51fa\u5230HDL\u5728\u9884\u9632\u52a8\u8109\u7ca5\u6837\u786c\u5316\u53d1\u5c55\u4e2d\u8d77\u7740\u91cd\u8981\u4f5c\u7528\u3002<\/p>\n\n\n\n

    \"\"<\/figure>\n\n\n\n

    \u56fe2. \u5185\u6e90\u6027\u8102\u86cb\u767d\u901a\u8def[1]<\/sup><\/p>\n\n\n\n

    LDL\u4e5f\u53ef\u4ee5\u88ab\u4f5c\u4e3a\u7ec6\u80de\u6216\u75be\u75c5\u6807\u5fd7\u7269\uff0c\u5185\u76ae\u7ec6\u80de\u3001\u5de8\u566c\u7ec6\u80de\u548c\u5c0f\u80f6\u8d28\u7ec6\u80de\u7b49\u7ec6\u80de\u5bf9LDL\u541e\u566c\u80fd\u529b\u7684\u6539\u53d8\uff0c\u5f80\u5f80\u5728\u5fc3\u8840\u7ba1\u548c\u8102\u8d28\u8fd0\u8f93\u7814\u7a76\u4e2d\u4f5c\u4e3a\u6807\u5fd7\u4e8b\u4ef6\u3002\u8367\u5149\u6807\u8bb0\u7684LDL\uff0c\u901a\u5e38\u88ab\u7528\u4e8e\u76f4\u63a5\u68c0\u6d4b\u7ec6\u80de\u541e\u566c\u6c34\u5e73\u80fd\u529b\u3002<\/p>\n\n\n\n

    \"\"<\/figure>\n\n\n\n

    03 \u4fee\u9970\u578b\u8102\u86cb\u767d<\/strong><\/h3>\n\n\n\n

    LDL\u5728\u4f53\u5185\u5b58\u5728\u7740\u4e0d\u540c\u7684\u4fee\u9970\uff0c\u5305\u62ec\u6c27\u5316\u7684LDL\uff08Oxidized LDL, Ox-LDL\uff09\u3001\u4e59\u9170\u5316\u7684LDL\uff08Acetylated LDL, Ac-LDL\uff09\u7b49\u3002\u5929\u7136LDL\u88ab\u7ec6\u80de\u6444\u53d6\u4f9d\u8d56\u4e8e\u7ec6\u80de\u819c\u8868\u9762\u7684LDL\u53d7\u4f53\uff08LDLR\uff09\u3002\u7136\u800c\uff0c\u5185\u76ae\u7ec6\u80de\u3001\u5de8\u566c\u7ec6\u80de\u548c\u5c0f\u80f6\u8d28\u7ec6\u80de\u7b49\u6444\u53d6Ox-LDL\u3001Ac-LDL\u7b49\u4fee\u9970\u578b\u8102\u86cb\u767d\u7684\u8fc7\u7a0b\uff0c\u5219\u66f4\u591a\u4f9d\u8d56\u4e8e\u7279\u5f02\u6027\u9488\u5bf9\u8fd9\u4e9b\u4fee\u9970\u578b\u8102\u86cb\u767d\u7684\u201c\u6e05\u9053\u592b\u201d\u53d7\u4f53\u3002\u5982\u4e0b\u56fe\u6240\u793a\uff0c\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u4e2d\uff0c\u9776\u5411\u4fee\u9970\u578b\u8102\u86cb\u767d\u7684\u201c\u6e05\u9053\u592b\u201d\u53d7\u4f53\u4e0d\u5c3d\u76f8\u540c\u3002[2]<\/sup>\u56e0\u6b64\uff0c\u7814\u7a76\u4e0d\u540c\u201c\u6e05\u9053\u592b\u201d\u53d7\u4f53\u7684\u529f\u80fd\uff0c\u5f80\u5f80\u9700\u8981\u9009\u62e9\u4e0d\u540c\u7c7b\u578b\u7684\u4fee\u9970\u578b\u8102\u86cb\u767d\u3002<\/p>\n\n\n\n

    \"\"<\/figure>\n\n\n\n

    \u56fe3. \u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u53d7\u4f53\u5206\u7c7b[2]<\/sup><\/p>\n\n\n\n

    \u5728\u7ec6\u80de\u635f\u4f24\u6a21\u578b\u4e0a\uff0cOx-LDL\u4e5f\u88ab\u7528\u4e8e\u8bf1\u5bfc\u67d0\u4e9b\u5de8\u566c\u7ec6\u80de\u4ea7\u751f\u6ce1\u6cab\u7ec6\u80de\uff08foam cell\uff09\uff0c\u4ee5\u7814\u7a76\u6ce1\u6cab\u7ec6\u80de\u4e0e\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u76f8\u5173\u6027[3]<\/sup>\u3002Ac-LDL\u53ef\u7528\u5728\u5185\u76ae\u7ec6\u80de\u548c\u5c0f\u795e\u7ecf\u80f6\u8d28\u7ec6\u80de\u7684\u529f\u80fd\u7814\u7a76\uff0c\u4e5f\u53ef\u7528\u4f5c\u6ce1\u6cab\u6837\u7ec6\u80de\u751f\u6210\u7684\u9633\u6027\u5bf9\u7167\u3002<\/p>\n\n\n\n

    04 \u8367\u5149\u6807\u8bb0\u8102\u86cb\u767d<\/strong><\/h3>\n\n\n\n

    \u4e3a\u4e86\u6ee1\u8db3\u591a\u91cd\u8367\u5149\u7684\u793a\u8e2a\u6807\u8bb0\uff0c\u6211\u4eec\u6709\u4e0d\u540c\u8367\u5149\u6807\u8bb0\u7684\u8102\u86cb\u767d\u53ef\u4ee5\u9009\u62e9\u3002\u5728\u51b3\u5b9a\u597dLDL\u5929\u7136\u578b\u6216\u8005\u4fee\u9970\u578b\u540e\uff0c\u6211\u4eec\u8fd8\u9700\u8981\u9009\u62e9\u5408\u9002\u7684\u8367\u5149\u57fa\u56e2\u3002\u901a\u8fc7\u5c06\u8367\u5149\u63a2\u9488\u4e0eLDL\u7ed3\u5408\uff0c\u4f7f\u5176\u5728\u7279\u5b9a\u6ce2\u957f\u4e0b\u53d1\u51fa\u8367\u5149\u4fe1\u53f7\uff0c\u4ece\u800c\u5b9e\u73b0\u5bf9LDL\u6444\u53d6\u3001\u8f6c\u8fd0\u53ca\u4ee3\u8c22\u8fc7\u7a0b\u7684\u5b9e\u65f6\u8ffd\u8e2a\u3002\u5982\u4e0b\u56fe\u6240\u793a\uff0c\u7814\u7a76\u4eba\u5458\u53ef\u4ee5\u4f7f\u7528\u8367\u5149\u6807\u8bb0\u7684\u8102\u86cb\u767d\u4e0e\u7ec6\u80de\u5171\u5b75\u80b2\uff0c\u4ece\u800c\u80fd\u5b9e\u73b0\u5728\u8367\u5149\u663e\u5fae\u955c\u4e0b\uff0c\u8ffd\u8e2a\u8102\u86cb\u767d\u7684\u6444\u53d6\u53ca\u4ee3\u8c22\u6d3b\u52a8\u8fc7\u7a0b\u3002ox-LDL\u8fdb\u5165\u7ec6\u80de\u540e\uff0c\u4f1a\u8f6c\u79fb\u5230\u665a\u671f\u5185\u4f53\u6216\u6eb6\u9176\u4f53\uff0c\u8fdb\u4e00\u6b65\u88ab\u964d\u89e3\u540e\u91ca\u653e\u6e38\u79bb\u80c6\u56fa\u9187\u3002\u901a\u8fc7\u7ed9ox-LDL\u6807\u8bb0\u8367\u5149\uff0c\u7814\u7a76\u4eba\u5458\u80fd\u5b9e\u73b0\u5bf9\u7ec6\u80de\u4e2d\u8102\u86cb\u767d\u7684\u8f6c\u8fd0\u8fd0\u8f93\u80fd\u529b\u8fdb\u884c\u68c0\u6d4b\u3002[4]<\/sup><\/p>\n\n\n\n

    \"\"<\/figure>\n\n\n\n

    \u56fe4. \u8367\u5149\u6807\u8bb0oxLDL\u8ffd\u8e2a\u7ec6\u80de\u6444\u53d6\u8102\u86cb\u767d\u80fd\u529b[4]<\/sup><\/p>\n\n\n\n

    LDL\u63a2\u9488\u79cd\u7c7b<\/h2>\n\n\n\n

    \u9664\u4e86\u672a\u6807\u8bb0\u7684LDL\u4ee5\u5916\uff0c\u6211\u4eec\u8fd8\u63d0\u4f9b\u4e24\u7c7b\u6807\u8bb0\u7684LDL\u63a2\u9488\uff1a\u4e00\u7c7b\u63a2\u9488\u542b\u6709\u672a\u4fee\u9970\u7684\u5929\u7136\u578bLDL\uff0c\u7528\u4e8e\u7814\u7a76\u6b63\u5e38\u80c6\u56fa\u9187\u7684\u9012\u9001\u548c\u5185\u5316\u673a\u5236\uff1b\u53e6\u4e00\u7c7b\u63a2\u9488\u542b\u6709Ox-LDL\u6216Ac-LDL\uff0c\u7528\u4e8e\u7814\u7a76\u8868\u8fbe\u7279\u5f02\u6027\u7ed3\u5408\u8be5\u4fee\u9970\u578bLDL \u7684\u53d7\u4f53\u7684\u5185\u76ae\u7ec6\u80de\u3001\u5c0f\u80f6\u8d28\u7ec6\u80de\u548c\u5176\u4ed6\u7ec6\u80de\u7c7b\u578b\u3002\u5728\u8367\u5149\u7c7b\u578b\u4e0a\uff0c\u6211\u4eec\u63d0\u4f9bAlexa Fluor\u3001DiI\u3001BODIPY FL\u4ee5\u53capHrodo\u8fd94\u7c7b\u8367\u5149\u6807\u8bb0\u57fa\u56e2\u7684\u9009\u62e9\u3002<\/p>\n\n\n\n

    \u8367\u5149\u57fa\u56e2\u7279\u6027<\/h2>\n\n\n\n

    \u5176\u4e2d\uff0cBODIPY FL\u5bb9\u6613\u88ab488 nm\u6fc0\u5149\u8c31\u7ebf\u6fc0\u53d1\uff0c\u4e14\u5176\u5316\u5b66\u7a33\u5b9a\u6027\u66f4\u9ad8\uff0c\u8010\u53d7\u591a\u5143\u73af\u5883\uff0c\u9002\u5408\u6d41\u5f0f\u7ec6\u80de\u672f\u548c\u5171\u805a\u7126\u6fc0\u5149\u663e\u5fae\u955c\u89c2\u5bdf\u3002DiI\u662f\u4e00\u7c7b\u4eb2\u8102\u6027\u67d3\u6599\uff0c\u67d3\u6599\u80fd\u591f\u5bb9\u6613\u5730\u8fdb\u5165LDL\u7684\u758f\u6c34\u90e8\u5206\uff0c\u786e\u4fdd\u6807\u8bb0\u7684\u51c6\u786e\u6027\u548c\u7a33\u5b9a\u6027\u3002\u800cAlexa Fluor\u5c5e\u4e8e\u5c0f\u5206\u5b50\u67d3\u6599\uff0c\u62e5\u6709\u660e\u4eae\u4e14\u5149\u7a33\u5b9a\u7684\u7279\u6027\uff0c\u53ef\u4ee5\u9002\u7528\u4e8e\u591a\u6807\u8bb0\u5b9e\u9a8c\u8fdb\u884c\u6d41\u5f0f\u7ec6\u80de\u4eea\u548c\u5171\u805a\u7126\u6fc0\u5149\u626b\u63cf\u663e\u5fae\u955c\u5206\u6790\u3002<\/p>\n\n\n\n

    \u5728\u5168\u90e8\u8367\u5149\u6807\u8bb0\u7684LDL\u76f8\u5173\u4ea7\u54c1\u4e2d\uff0c\u6709\u4e00\u7c7b\u7279\u6b8a\u7684\u8367\u5149\u57fa\u56e2pHrodo\u3002\u8fd9\u7c7b\u8367\u5149\u57fa\u56e2\u662fpH\u654f\u611f\u578b\u7684\u63a2\u9488\u3002\u8fd9\u4e9b\u67d3\u6599\u5728\u9178\u6027\u73af\u5883\u4e2d\u53d1\u51fa\u8367\u5149\u4f46\u5728\u4e2d\u6027 pH \u503c\u73af\u5883\u4e0b\u51e0\u4e4e\u4e0d\u663e\u793a\u4fe1\u53f7\u3002\u5f53 pH \u73af\u5883\u9178\u5316\u65f6\uff0cpHrodo \u67d3\u6599\u7684\u8367\u5149\u589e\u52a0\u4e0e\u7ec6\u80de\u5185\u56ca\u6ce1\u9178\u5316\u76f8\u5173\uff0c\u8fd9\u4f7f\u5f97\u8fd9\u4e9b\u67d3\u6599\u6210\u4e3a\u7814\u7a76\u5185\u541e\u4f5c\u7528\u6216\u541e\u566c\u4f5c\u7528\u53ca\u5176\u53d7\u73af\u5883\u56e0\u7d20\u3001\u836f\u7269\u6216\u75c5\u539f\u4f53\u8c03\u8282\u7684\u5b9d\u8d35\u5de5\u5177\u3002\u5728\u540e\u9762\u7684\u63a8\u6587\u4e2d\uff0c\u6211\u4eec\u4e5f\u4f1a\u8be6\u7ec6\u6765\u770b\uff0c\u4ee5pHrodo\u8fd9\u7c7b\u67d3\u6599\u4e3a\u4ee3\u8868\u7684\uff0c\u6297\u4f53\u6807\u8bb0\u7c7b\u4ea7\u54c1\u5728\u6297\u4f53\u836f\u7b5b\u9009\u6807\u8bb0\u4ee5\u53ca\u541e\u566c\u68c0\u6d4b\u4e2d\u7684\u5e94\u7528\u3002<\/p>\n\n\n\n

    LDL complex<\/td>Modification<\/td>Cat. No.<\/td>Ex\/Em1<\/td>Content<\/td><\/tr>
    Unlabeled LDL<\/td>Native
    (unoxidized)<\/td>    		L3486<\/td>N\/A<\/td>200 \u03bcL (2.5 mg\/mL) LDL<\/td><\/tr>
    BODIPYTM<\/sup> FLLDL3<\/sup><\/td><\/td>L3483<\/td>515\/520<\/td>200 \u03bcL (1 mg\/mL)LDL<\/td><\/tr>
    DilLDL3<\/sup><\/td><\/td>L3482<\/td>554\/571<\/td>200 \u03bcL (1 mg\/mL) LDL<\/td><\/tr>
    phrodoTM<\/sup> Green LDL<\/td><\/td>L34355<\/td>509\/533<\/td>200 \u03bcL (1 mg\/mL)LDL<\/td><\/tr>
    pHrodoTM<\/sup> Red LDL<\/td><\/td>L34356<\/td>560\/585<\/td>200 \u03bcL(1 mg\/mL)LDL<\/td><\/tr>
    Ox-LDL<\/td>Oxidized<\/td>L34357<\/td>N\/A<\/td>200 \u03bcL (2.5 mg\/mL)LDL<\/td><\/tr>
    Dil Ox-LDL<\/td><\/td>L34358<\/td>554\/571<\/td>200 \u03bcL(1 mg\/m) LDL<\/td><\/tr>
    Unlabeled AcLDL<\/td>Acetylated<\/td>L34354<\/td>N\/A<\/td>200 \u03bcL (2.5 mg\/mL)LDL<\/td><\/tr>
    Aexa FluorTM<\/sup> 488 AcLDL<\/td><\/td>L23380<\/td>495\/519<\/td>200 \u03bcL(1 mg\/mL) LDL<\/td><\/tr>
    Dil AcLDL3<\/sup><\/td><\/td>L3484<\/td>554\/571<\/td>200 \u03bcL (1 mg\/mL)LDL<\/td><\/tr>
    Alexa FluorTM<\/sup> 594 AcLDL<\/td><\/td>L35353<\/td>590\/617<\/td>200 \u03bcL(1 mg\/mL)LDL<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

    \u53c2\u8003\u6587\u732e<\/p>\n\n\n\n

    1. Feingold, K. R. (2022). Lipid and lipoprotein metabolism. Endocrinology and Metabolism Clinics, 51(3), 437-458.<\/p>\n\n\n\n

    2. Ashraf, M. Z., & Gupta, N. (2011). Scavenger receptors: implications in atherothrombotic disorders. The international journal of biochemistry & cell biology, 43(5), 697-700.<\/p>\n\n\n\n

    3. Guo, J., & Du, L. (2024). An update on ox-LDL-inducing vascular smooth muscle cell-derived foam cells in atherosclerosis. Frontiers in Cell and Developmental Biology, 12, 1481505.<\/p>\n\n\n\n

    4. Liang K, Dai JY. Progress of potential drugs targeted in lipid metabolism research. Front Pharmacol. 2022 Dec 16;13:1067652. doi: 10.3389\/fphar.2022.1067652. PMID: 36588702; PMCID: PMC9800514.<\/p>\n\n\n\n

    \"contact<\/a><\/figure>\n\n\n\n

    <\/p>\n","protected":false},"excerpt":{"rendered":"

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