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Invitrogen
ABH1 Polyclonal Antibody
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ABH1 Antibody (PA5-92844) in WB
Western Blot analysis of ABH1 in extracts of various cell lines using ABH1 Polyclonal Antibody (Product # PA5-92844) at a dilution of 1:1000. A HRP Goat Anti-Rabbit IgG (H+L) secondary antibody was used at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST.
产品信息
PA5-92844
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 110-389 of human ALKBH1
偶联物
形式
Liquid
浓度
2.87 mg/mL
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
产品详细信息
Immunogen sequence: YQWHWVKQCL KLYSQKPNVC NLDKHMSKEE TQDLWEQSKE FLRYKEATKR RPRSLLEKLR WVTVGYHYNW DSKKYSADHY TPFPSDLGFL SEQVAAACGF EDFRAEAGIL NYYRLDSTLG IHVDRSELDH SKPLLSFSFG QSAIFLLGGL QRDEAPTAMF MHSGDIMIMS GFSRLLNHAV PRVLPNPEGE GLPHCLEAPL PAVLPRDSMV EPCSMEDWQV CASYLKTARV NMTVRQVLAT DQNFPLEPIE DEKRDISTEG FCHLDDQNSE VKRARINPDS; Positive Samples: HT-29, 293T, HepG2, MCF-7; Cellular Location: Mitochondrion, Nucleus
靶标信息
This gene encodes a homolog to the E. coli alkB gene product. The E. coli alkB protein is part of the adaptive response mechanism of DNA alkylation damage repair. It is involved in damage reversal by oxidative demethylation of 1-methyladenine and 3-methylcytosine. Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation. Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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