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The monoclonal antibody 8D7 is cross reactive with human ASGPR.
The asialoglycooprotein receptor (ASGPR) is a transmembrane glycoprotein (42 kDa) which mediates binding, internalization and degradation of extracellular glycoproteins that have exposed terminal galactose residues. The receptor is expressed on the surface of the hepatocytes in a polar manner, i. e. it is present on the sinusoidal and lateral plasma membranes but not on the bile canalicular membrane. The mammalian hepatic ASGPR mediate the endocytosis and degradation of serum proteins from which terminal sialic residues have been removed. The rat asialoglycoprotein receptor (ASGPR) consists of three polypeptide subunits: rat hepatic lectin (RHL)-1, RHL-2 and RHL-3. The monoclonal antibody 8D7 recognizes a subunit-specific epitope of RHL-1 of rat ASGPR. The monoclonal antibody 8D7 is cross reactive with human ASGPR.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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蛋白别名: ASGP-R 1; ASGPR 1; asialoglycoprotein receptor (RHL1); Asialoglycoprotein receptor 1; Asialoglycoprotein receptor 1 (hepatic lectin); asialoglycoprotein receptor RHL1; Hepatic lectin 1; hepatic lectin 1 RHL1; hepatic lectin 1, RHL1; HL-1; RHL-1
基因别名: ASGR; Asgr-1; Asgr1; RATRHL1; RHL1
UniProt ID: (Rat) P02706
Entrez Gene ID: (Rat) 24210