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Invitrogen
ATR Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5149972
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Ataxia Telangiectasia And Rad3 Related Protein (ATR) (Ala2353-Met2644)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2310008J16Rik; 2810405N18Rik; ataxia telangiectasia and Rad3 related; ataxia telangiectasia and rad3 related-like; ataxia telangiectasia and Rad3-related protein; atr; ATR serine/threonine kinase; EC 2.7.11.1; FRAP-related protein-1; kinase ATR; MEC1, mitosis entry checkpoint 1, homolog; protein kinase ATR; TEM8; unnamed protein product
Gene Aliases: FCTCS; FRP1; MEC1; SCKL; SCKL1
UniProt ID: (Human) Q13535
Entrez Gene ID: (Human) 545, (Mouse) 245000, (Rat) 685055
DNA damage checkpoint
G2/M transition of mitotic cell cycle
telomere maintenance
DNA replication
DNA repair
double-strand break repair
chromatin remodeling
protein phosphorylation
cellular response to DNA damage stimulus
nuclear envelope organization
embryo implantation
negative regulation of DNA replication
response to mechanical stimulus
replication fork processing
positive regulation of telomere maintenance via telomerase
cellular response to UV
positive regulation of DNA damage response, signal transduction by p53 class mediator
mitotic G2/M transition checkpoint
nuclear envelope disassembly
chromosome organization
protein localization to chromosome, telomeric region
cellular response to gamma radiation
replicative senescence
establishment of RNA localization to telomere
DNA strand resection involved in replication fork processing
positive regulation of telomerase catalytic core complex assembly
protein localization to site of double-strand break
regulation of double-strand break repair
response to xenobiotic stimulus
interstrand cross-link repair
response to arsenic-containing substance
regulation of cellular response to stress
establishment of macromolecular complex localization to telomere
regulation of cellular response to heat
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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