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Invitrogen
AgRP Polyclonal Antibody
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AgRP Antibody (PA1-18414) in IHC (P)
Immunohistochemistry was performed on 4% paraformaldehyde-fixed paraffin-embedded mouse brain tissue sections. To expose target antigens, tissues were treated with 15 µg/mL Proteinase K in PBS containing 0.01% Triton X-100 for 5 minutes. Tissues were blocked for 1 hour and probed with an Agouti Related Protein polyclonal antibody (Product # PA1-18414) at a dilution of 1:200 overnight at 4°C. Tissues were wa... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA1-18414
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Sheep,
Rat
已发表种属
Mouse
宿主/亚型
Guinea pig
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to a region (82-131) within the carboxy domain of mouse agouti related protein conjugated to carrier protein.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
Conc. Not Determined
保存液
whole serum
内含物
no preservative
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute in 50 µL sterile water. Centrifuge to remove any insoluble material. Store lyophilized antibody at 2-8 °C. It is recommended that a thawed sample is stored at 4 °C for no longer than 2 weeks. Allocation of appropriate anti-bacterial agent can increase shelf life by several weeks. Diluted serum should be prepared as required. Long term stability requires storage, preferably in small aliquots at -20 °C or lower. Glycerol (1:1) can be added to neat serum for additional stability if intended use does not prevent this.
靶标信息
Agouti-related protein (AgRP), also called agouti-related peptide, is a neuropeptide produced in the brain by the AgRP/NPY neuron. In humans, the agouti-related peptide is encoded by the AGRP gene. This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: agouti related protein homolog; AGRP; orexigenic neuropeptide
基因别名: AGRT; ART; ASIP2
UniProt ID: (Human) O00253, (Mouse) P56473
Entrez Gene ID: (Sheep) 443269, (Human) 181, (Mouse) 11604, (Rat) 25582
neuropeptide signaling pathway
circadian rhythm
adult feeding behavior
hormone-mediated signaling pathway
regulation of appetite
positive regulation of appetite
response to insulin
eating behavior
long-day photoperiodism
maternal process involved in female pregnancy
regulation of feeding behavior
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
positive regulation of feeding behavior
positive regulation of eating behavior
feeding behavior
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