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Invitrogen
BACE2 Polyclonal Antibody
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图: 1 / 11
BACE2 Antibody (PA5-145367) in IHC (P)
Immunohistochemistry (Paraffin) analysis of BACE2 in mouse cardiac muscle tissue using BACE2 Polyclonal Antibody (Product # PA5-145367) (20 µg/mL) and using PBS intead of the primary antibody as a control. The sample was then stained with HRP-Goat anti-Rabbit IgG polyclonal secondary antibody (2 µg/mL). DAB staining.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-145367
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Rat BACE2 protein, Gly242-Val502 (Accession #Q6IE75)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography, Protein A
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.05% Proclin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
BACE2 or Beta Secretase 2 is responsible for the proteolytic processing of the amyloid precursor protein (APP). BACE2 cleaves APP between residues 690 and 691. This cleavage leads to the generation and extracellular release of beta-cleaved soluble APP. BACE2 is also know to cleave APP between residues 671 and 672. Accumulation of APP is a signature of Alzheimer disease and frequent complication of adult Down syndrome patients.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 56 kDa aspartic-like protease; Asp1; aspartyl protease 1; be; beta secretase 2; beta-site amyloid beta A4 precursor protein-cleaving enzyme 2; beta-site amyloid precursor protein cleaving enzyme 2; beta-site APP processing enzyme; beta-site APP-cleaving enzyme 2; Down syndrome region aspartic protease; memapsin-1; membrane-associated aspartic protease 1; SLCO3A1/BACE2 fusion; theta-secretase; transmembrane aspartic proteinase Asp1; unnamed protein product
基因别名: 1110059C24Rik; AEPLC; ALP56; ARP1; ASP1; ASP21; BAE2; CDA13; CEAP1; DRAP
UniProt ID: (Human) Q9Y5Z0, (Mouse) Q9JL18, (Rat) Q6IE75
Entrez Gene ID: (Human) 25825, (Mouse) 56175, (Rat) 288227
proteolysis
membrane protein ectodomain proteolysis
protein processing
melanosome organization
glucose homeostasis
negative regulation of amyloid precursor protein biosynthetic process
beta-amyloid metabolic process
signaling receptor ligand precursor processing
astrocyte activation
peptide hormone processing
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