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Invitrogen
CD142 Monoclonal Antibody (K06319_4H12)
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CD142 Antibody (MA5-55973) in IHC (P)
Immunohistochemistry analysis of CD142 in paraffin-embedded kidney tissue. Sample was incubated with CD142 monoclonal antibody (Product # MA5-55973) at a dilution of 7.5 µg/mL (RT, 1 hour). Antigen was retrieved through addition of boiling Tris/EDTA buffer pH 9 in a pressure cooker for 3 min. Endogenous peroxidase activity was quenched by incubating the sections with 3% H2O2 for 30 min at room temperature. ... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-55973
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
K06319_4H12
抗原
Recombinant human F3 (immunogen range is 91-160).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.69 mg/mL
规格
34.5 µg
纯化类型
Protein A
保存液
PBS with 50% glycerol, 0.5% BSA
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
产品详细信息
Sequence of this protein is as follows: LTDEIVKDVK QTYLARVFSY PAGNVESTGS AGEPLYENSP EFTPYLETNL GQPTIQSFEQ VGTKVNVTVE
靶标信息
This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: coagulation factor; coagulation factor III (thromboplastin, tissue factor); F3; tissue factor precursor; tissue factor versions 1 and 2 precursor; unnamed protein product
基因别名: CD142; TF; TFA
UniProt ID: (Human) P13726
Entrez Gene ID: (Human) 2152
positive regulation of endothelial cell proliferation
activation of plasma proteins involved in acute inflammatory response
activation of blood coagulation via clotting cascade
proteolysis
response to stress
blood coagulation
blood coagulation, intrinsic pathway
blood coagulation, extrinsic pathway
response to wounding
positive regulation of gene expression
positive regulation of platelet-derived growth factor receptor signaling pathway
protein processing
cytokine-mediated signaling pathway
positive regulation of cell migration
positive regulation of TOR signaling
positive regulation of interleukin-8 production
positive regulation of angiogenesis
positive regulation of positive chemotaxis
blood coagulation, fibrin clot formation
positive regulation of endothelial cell apoptotic process
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