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Invitrogen
CD2 Monoclonal Antibody (CC42)
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CD2 Antibody (MA5-28311) in Flow
Flow cytometry of CD2 in red cell lysed bovine blood. Sample was incubated with CD2 monoclonal antibody (Product # MA5-28311) and gated on lymphocytes. Figures are arranged as follows: A) Alexa Fluor 647 conjugated mouse anti bovine CD4 and FITC conjugated mouse IgG1 isotype control. B) Alexa Fluor 647 conjugated mouse anti bovine CD4 and FITC conjugated mouse anti bovine CD2.
产品信息
MA5-28311
应用
建议稀释比
已发表文章
产品规格
种属反应
Bovine
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
CC42
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Mouse anti Bovine CD2, clone CC42, recognizes the bovine homologue of human CD2. Clone CC42 inhibits rosetting with SRBC and stains cells in primary and secondary lymphoid organs in patterns consistent with those seen by human CD2 monoclonal antibodies.
靶标信息
CD2 (LFA-2) is a monomeric surface antigen (MW range 45-58 kDa) of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells. CD2 is one of the earliest T-cell markers, being present on more than 95% of thymocytes and it is also found on some natural killer cells, but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it. The interaction between CD2 and CD58 stabilizes adhesion between T cells and antigen presenting or target cells. Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cell-cell interface to provide tight adhesion. Moreover, T cell activation induces increased CD2 expression and its lateral mobility, making easier contact between CD2 and CD58. Subsequently, T cell activation causes fixation of CD58-CD2 at sites of cell-cell contact, thereby strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and helps to control infection. Diseases associated with CD2 dysfunction include penis squamous cell carcinoma and immune deficiency due to the absence of the thymus.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD2 antigen (p50), sheep red blood cell receptor; cluster of differentiation 2; FLJ46032
Entrez Gene ID: (Bovine) 497022
