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Invitrogen
CD3 Monoclonal Antibody (MM1A)
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CD3 Antibody (MA5-28343) in Flow
Flow cytometry of CD3 in bovine peripheral blood lymphocytes. Sample was incubated with CD3 monoclonal antibody (Product # MA5-28343). Figures are arranged as follows: A) Mouse IgG1 negative control followed by Goat anti Mouse IgG1 - PE. B) Mouse anti Bovine CD3 antibody, clone MM1A followed by Goat anti Mouse IgG1 - PE secondary antibody.
产品信息
MA5-28343
产品规格
种属反应
Bovine
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
MM1A
抗原
Monocyte enriched bovine mononuclear cells
偶联物
形式
Liquid
浓度
1.0 mg/mL
规格
100 µg
保存液
tissue culture supernatant
内含物
0.09% sodium azide
保存条件
4°C, do not freeze
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Mouse anti Bovine CD3, clone MM1A, recognizes bovine CD3.
靶标信息
The CD3 complex, composed of gamma, delta, epsilon, and zeta subunits, is essential for the assembly, trafficking, and surface expression of the T cell receptor (TCR) complex. These subunits are structurally related members of the immunoglobulin superfamily and are encoded by closely linked genes on human chromosome 11. CD3 is expressed by thymocytes in a developmentally regulated manner and by all mature T cells, but not on B or NK cells. The CD3 subunits play a crucial role in transducing antigen-recognition signals into the cytoplasm of T cells. The cytoplasmic tails of CD3 subunits contain a double tyrosine-based motif that associates with cytoplasmic signal transduction molecules, mediating T cell activation through the TCR. Crosslinking of the TCR initiates intracellular biochemical pathways that result in cellular activation, proliferation, and potentially growth arrest and cell survival. CD3 is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes, and Purkinje cells in the cerebellum. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. Defects in the CD3 gene are associated with CD3 immunodeficiency, highlighting its importance in immune function and regulation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: antigen CD3D, delta polypeptide (TiT3 complex); antigen CD3E, epsilon polypeptide (TiT3 complex); antigen CD3G, gamma polypeptide; antigen CD3Z, zeta polypeptide; CD3 TCR complex; CD3d; CD3d molecule, delta (CD3-TCR complex); CD3e; CD3e molecule, epsilon (CD3-TCR complex); CD3G antigen, gamma polypeptide; CD3g molecule, gamma (CD3-TCR complex); FLJ18683; Leu-4; T cell antigen receptor complex epsilon subunit of T3; T-cell receptor T3 delta chain; T-cell receptor T3 gamma chain; T-cell surface glycoprotein CD3 delta chain; T-cell surface glycoprotein CD3 epsilon chain; T3/TCR complex
基因别名: CD3D; CD3E; CD3Z
UniProt ID: (Bovine) Q28072, (Bovine) Q28073
Entrez Gene ID: (Bovine) 281056, (Bovine) 281053, (Bovine) 281054, (Bovine) 281055
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