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Invitrogen
CHCHD6 Polyclonal Antibody
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产品信息
PA5-65691
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human CHCHD6
偶联物
形式
Liquid
浓度
0.4 mg/mL
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
Immunogen sequence: RDTFYKEQLER IERKNAEMYK LSSEQFHEAA SKMESTIKPR RVEPVCSGLQ AQILHCYRDR PHEVLLCSDL VKAYQRCVSA AHK
Highest antigen sequence identity to the following orthologs - mouse 85%, rat 85%.
靶标信息
CHCHD6 is a member of a family of proteins containing a conserved (coiled coil 1)-(helix 1)-(coiled coil 2)-(helix 2) domain and has been observed in a complex with the mitochondrial proteins mitofilin, SAM50, metaxins 1 and 2, and CHCHD3. CHCHD6 knockdown causes severe defects in mitochondrial cristae morphology as well as reductions in cell growth, ATP production and oxygen consumption. This decrease of CHCHD6 also led to a reduction in mitofilin protein levels, while a knockdown of mitofilin resulted in a reduced level of CHCHD6, suggesting coordinate regulation between these two proteins. CHCHD6 knockdown in human cancer cells enhances their sensitivity to genotoxic anticancer drugs, suggesting that CHCHD6 may be a potential therapeutic anti-tumor target.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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