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Invitrogen
CLN2 Polyclonal Antibody
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CLN2 Antibody (PA5-111084) in IHC (P)
Immunohistochemistry analysis of CLN2 in human kidney, liver, skeletal muscle and testis. Samples were incubated with CLN2 polyclonal antibody (Product # PA5-111084). Shows similar protein distribution across tissues to independent CLN2 antibody (Product # PA5-111206) (B).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-111084
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.05 mg/mL
规格
5 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: GCWSVSGRHQ FRPTFPASSP YVTTVGGTSF QEPFLITNEI VDYISGGGFS NVFPRPSYQE EAVTKFLSSS PHLPPSSYFN ASGRAYPDVA ALSDGYW
Highest antigen sequence indentity to the following orthologs: Rat - 89%, Mouse - 89%.
靶标信息
This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cell growth-inhibiting gene 1 protein; CLN 2; GIG 1; GIG1; growth-inhibiting protein 1; lysosomal pepstatin insensitive protease; lysosomal pepstatin-insensitive carboxypeptidase; MGC21297; TPP 1; TPP I; TPPI; tripeptidyl aminopeptidase; tripeptidyl peptidase I; unnamed protein product
基因别名: CLN2; GIG1; LPIC; SCAR7; TPP-1
UniProt ID: (Human) O14773
Entrez Gene ID: (Human) 1200
proteolysis
lipid metabolic process
lysosome organization
nervous system development
central nervous system development
protein catabolic process
epithelial cell differentiation
peptide catabolic process
bone resorption
neuromuscular process controlling balance
protein localization to chromosome, telomeric region
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
