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Invitrogen
Calreticulin Recombinant Rabbit Monoclonal Antibody (HL2057)
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Calreticulin Antibody (MA5-47272) in WB
Western blot analysis of Calreticulin in Various whole cell extracts (30 µg) separated by 10% SDS-PAGE. Membrane was blotted with Calreticulin Monoclonal antibody (Product # MA5-47272) using a dilution of 1:1,000 followed by HRP-conjugated anti-rabbit IgG secondary antibody. Corresponding RNA expression data for the same cell lines are based on Human Protein Atlas program.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-47272
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL2057
抗原
Recombinant fragmemt of human Calreticulin
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Store as concentrated solution.
Centrifuge briefly prior to opening vial.
靶标信息
Calr or Calreticulin is a calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. Calr, a lectin, interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Calr also interacts with with the DNA-binding domain of NR3C1 and mediates its nuclear export. It may also be involved in maternal gene expression regulation and oocyte maturation via the regulation of calcium homeostasis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Autoantigen RO; CALR; calregulin; CRP55; endoplasmic reticulum resident protein 60; epididymis secretory sperm binding protein Li 99n; ERp60; FLJ26680; grp60; HACBP; Ro ribonucleoprotein autoantigen (Ro/SS-A) precursor; Ro/SS-A Antigen; Sicca syndrome antigen A (autoantigen Ro; calreticulin); unnamed protein product
基因别名: CALR1; cC1qR; CRT; HEL-S-99n; RO; SSA
UniProt ID: (Human) P27797
Entrez Gene ID: (Human) 811
complement component C1q binding
DNA binding
RNA binding
mRNA binding
nuclear export signal receptor activity
integrin binding
iron ion binding
calcium ion binding
protein binding
zinc ion binding
carbohydrate binding
protein binding, bridging
ubiquitin protein ligase binding
peptide binding
hormone binding
protein binding involved in protein folding
androgen receptor binding
negative regulation of transcription from RNA polymerase II promoter
peptide antigen assembly with MHC class I protein complex
regulation of transcription, DNA-templated
protein folding
protein export from nucleus
cellular calcium ion homeostasis
spermatogenesis
positive regulation of cell proliferation
response to xenobiotic stimulus
positive regulation of endothelial cell migration
positive regulation of gene expression
negative regulation of translation
response to estradiol
negative regulation of intracellular steroid hormone receptor signaling pathway
response to testosterone
protein localization to nucleus
protein folding in endoplasmic reticulum
ERAD pathway
glucocorticoid receptor signaling pathway
regulation of apoptotic process
negative regulation of neuron differentiation
positive regulation of cell cycle
negative regulation of transcription, DNA-templated
negative regulation of retinoic acid receptor signaling pathway
positive regulation of phagocytosis
protein stabilization
protein maturation
cardiac muscle cell differentiation
cellular response to electrical stimulus
cellular response to lithium ion
cellular senescence
cellular response to virus
positive regulation of substrate adhesion-dependent cell spreading
negative regulation of trophoblast cell migration
response to peptide
response to glycoside
response to biphenyl
positive regulation of dendritic cell chemotaxis
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