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Proteintech
EDAR Polyclonal Antibody
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产品信息
18032-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
EDAR Fusion Protein Ag12601 (207-448 aa encoded by BC093872)
偶联物
形式
Liquid
浓度
0.15 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MFYILKTKP SAPACCTSHP GKSVEAQVSK DEEKKEAPDN VVMFSEKDEF EKLTATPAKP TKSENDASSE NEQLLSRSVD SDEEPAPDKQ GSPELCLLSL VHLAREKSAT SNKSAGIQSR RKKILDVYAN VCGVVEGLSP TELPFDCLEK TSRMLSSTYN SEKAVVKTWR HLAESFGLKR DEIGGMTDGM QLFDRISTAG YSIPELLTKL VQIERLDAVE SLCADILEWA GVVPPASQPH AAS (207-448 aa encoded by BC093872)
靶标信息
This gene encodes a member of the tumor necrosis factor receptor family. The encoded transmembrane protein is a receptor for the soluble ligand ectodysplasin A, and can activate the nuclear factor-kappaB, JNK, and caspase-independent cell death pathways. It is required for the development of hair, teeth, and other ectodermal derivatives. Mutations in this gene result in autosomal dominant and recessive forms of hypohidrotic ectodermal dysplasia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Anhidrotic ectodysplasin receptor 1; Downless homolog; downless, mouse, homolog of; Ectodermal dysplasia receptor; ectodysplasin 1, anhidrotic receptor; Ectodysplasin-A receptor; EDA-A1 receptor; Tumor necrosis factor receptor superfamily member EDAR
基因别名: DL; ECTD10A; ECTD10B; ED1R; ED3; ED5; EDA-A1R; EDA1R; EDA3; EDAR; HRM1
UniProt ID: (Human) Q9UNE0
Entrez Gene ID: (Human) 10913
hair follicle development
apoptotic process
epidermis development
positive regulation of gene expression
cell differentiation
tumor necrosis factor-mediated signaling pathway
positive regulation of NF-kappaB import into nucleus
odontogenesis of dentin-containing tooth
positive regulation of I-kappaB kinase/NF-kappaB signaling
pigmentation
positive regulation of JNK cascade
salivary gland cavitation
