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Invitrogen
EFCAB4A Polyclonal Antibody
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产品信息
PA5-61187
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.4 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: LEAVFESLDQ AHTGFLTARE FCLGLGMFVG VASAQGANPC RTPEETFESG GLDVQGTAGS LDEE
Highest antigen sequence identity to the following orthologs: Mouse - 77%, Rat - 77%.
靶标信息
EFCAB4A, also known as Calcium release-activated calcium channel regulator 2B, is a novel Ca2+-binding EF-hand protein that is thought to play a key role in store-operated Ca2+ entry in T-cells by regulating CRAC channel activation, but the detailed function is still under investigation. It is likely to play a similar role as the related protein EFCAB4B, which acts as a cytoplasmic calcium-sensor that forms a complex with ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+ concentration.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ca2+ release-activated Ca2+ (CRAC) channel regulator 2B; Calcium release-activated calcium channel regulator 2B; Calcium release-activated channel regulator 2B; CRAC channel regulator 2B; CRAC regulator 2B; EF-hand calcium binding domain 4A; EF-hand calcium-binding domain-containing protein 4A
基因别名: CRACR2B; EFCAB4A
UniProt ID: (Human) Q8N4Y2
Entrez Gene ID: (Human) 283229
