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Osenses
FSH R Polyclonal Antibody
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Product Details
OSF00001W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from mouse FSH Receptor conjugated to blue carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide shares 96% identity with human sequence.
Specificity of this antibody: FSHR.
Target Information
Follicle-Stimulating Hormone Receptor (FSHR) expression has been reported in ovary, uterus, and testis. ESTs have been isolated from testis libraries. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This turn-off activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Follicle-stimulating hormone receptor; Follitropin receptor; FSH-R
Gene Aliases: Fshr
UniProt ID: (Mouse) P35378
Entrez Gene ID: (Mouse) 14309
ovarian follicle development
primary ovarian follicle growth
regulation of protein phosphorylation
regulation of systemic arterial blood pressure
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
spermatogenesis
spermatid development
locomotory behavior
female gonad development
hormone-mediated signaling pathway
cellular water homeostasis
regulation of platelet-derived growth factor receptor signaling pathway
ovulation cycle process
neuron projection development
regulation of hormone metabolic process
regulation of chromosome organization
regulation of intracellular estrogen receptor signaling pathway
positive regulation of intracellular estrogen receptor signaling pathway
sperm chromatin condensation
spermatogenesis, exchange of chromosomal proteins
follicle-stimulating hormone signaling pathway
regulation of MAPK cascade
transcytosis
regulation of osteoclast differentiation
negative regulation of bone resorption
Sertoli cell development
Sertoli cell proliferation
uterus development
regulation of acetylcholine metabolic process
basement membrane organization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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