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Proteintech
GNA13 Monoclonal Antibody (2G8F10), CoraLite® Plus 488
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产品信息
CL488-67188
产品规格
种属反应
Human,
Mouse,
Pig,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
2G8F10
抗原
GNA13 fusion protein Ag7316
偶联物
激发/发射光谱
493/522 nm
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
内含物
0.05% ProClin 300
保存条件
-20°C, store in dark
运输条件
Wet ice
产品详细信息
Immunogen sequence: MADFLPSRS VLSVCFPGCL LTSGEAEQQR KSKEIDKCLS REKTYVKRLV KILLLGAGES GKSTFLKQMR IIHGQDFDQR AREEFRPTIY SNVIKGMRVL VDAREKLHIP WGDNSNQQHG DKMMSFDTRA PMAAQGMVET RVFLQYLPAI RALWADSGIQ NAYDRRREFQ LGESVKYFLD NLDKLGEPDY IPSQQDILLA RRPTKGIHEY DFEIKNVPFK MVDVGGQRSE RKRWFECFDS VTSILFLVSS SEFDQVLMED RLTNRLTESL NIFETIVNNR VFSNVSIILF LNKTDLLEEK VQIVSIKDYF LEFEGDPHCL RDVQKFLVEC FRNKRRDQQQ KPLYHHFTTA INTENIRLVF RDVKDTILHD NLKQLMLQ
靶标信息
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:15240885, PubMed:16787920, PubMed:16705036, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway (PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: G alpha 13; G alpha-13; G-protein subunit alpha-13; Galpha 13; guanine nucleotide binding protein (G protein), alpha 13; guanine nucleotide binding protein, alpha 13; Guanine nucleotide-binding protein subunit alpha-13
基因别名: AU024132; AU043124; G13; Galpha13; Gna-13; GNA13
UniProt ID: (Human) Q14344, (Mouse) P27601, (Rat) Q6Q7Y5
Entrez Gene ID: (Pig) 100522824, (Human) 10672, (Mouse) 14674, (Rat) 303634
GTPase activity
signal transducer activity
protein binding
GTP binding
G-protein beta/gamma-subunit complex binding
type 1 angiotensin receptor binding
D5 dopamine receptor binding
metal ion binding
nucleotide binding
G-protein coupled receptor binding
guanyl nucleotide binding
heterotrimeric G-protein
patterning of blood vessels
in utero embryonic development
movement of cell or subcellular component
signal transduction
adenylate cyclase-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
Rho protein signal transduction
regulation of cell shape
cell differentiation
platelet activation
regulation of cell migration
activation of phospholipase D activity
angiogenesis
G-protein coupled receptor signaling pathway
small GTPase mediated signal transduction
intracellular signal transduction
metabolic process
