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Invitrogen
GPR68 Polyclonal Antibody
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图: 1 / 2
GPR68 Antibody (720277) in ICC/IF
Immunofluorescence was performed on HEK-293 cells transfected with GPR68 expression plasmid. 24 hours post transection, cells were fixed and permeabilized for detection of GPR68 using Anti-GPR68 Rabbit Polyclonal Antibody (Product # 720277, 2 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of GPR68 protein (green), Panel b) is stained for nuclei (blue) using ... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
720277
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide corresponding to Human GPR68 (aa 342-366)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.2-7.4, with 30% glycerol, 0.1% BSA
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
These Polyclonal antibodies are of rabbit origin developed by immunizing animals with proteins or peptides. The polyclonal antibody is purified by affinity purification from the rabbit sera generated after immunizing the rabbits with a specific type of protein or peptide. The purified antibody is tested for its functionality in various relevant research applications. The antibody is developed for Research Use Only and is non-hazardous or non-infectious in nature.
This antibody is predicted to react with Monkey, Rat, Mouse and Rabbit.
靶标信息
GPR68 (also known as OGR1 - ovarian cancer G-protein coupled receptor 1) is a proton-sensing receptor involved in pH homeostasis. It represents an osteoblastic pH sensor regulating the cell-mediated response to acidosis in bone. GPR68 mediates its action by association with G proteins that stimulate inositol phosphate (IP) production or CA2+ mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Also found to serve as a tumor suppressor in prostate cancer. Mutations to the gene result in amelogenesis imperfecta, hypomaturation type 2A6.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Brgr1; Brgrb; G protein-coupled receptor GPR68; G-protein coupled receptor 12A; OGR1; GPR68; ovarian cancer G protein-coupled receptor, 1; ovarian cancer G-protein coupled receptor 1; ovarian cancer G-protein coupled receptor 1 homolog; sphingosylphosphorylcholine receptor; unnamed protein product
基因别名: AI2A6; GPR12A; OGR1
UniProt ID: (Human) Q15743, (Mouse) Q8BFQ3
Entrez Gene ID: (Human) 8111, (Mouse) 238377
G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of insulin secretion
response to fluid shear stress
positive regulation of insulin secretion involved in cellular response to glucose stimulus
negative regulation of monocyte differentiation
cellular response to pH
cellular response to acidic pH
positive regulation of osteoclast development
inflammatory response
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