Invitrogen

IFN beta Polyclonal Antibody

Name: IFN beta Polyclonal Antibody
Brand: Invitrogen
SKU: 324001

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说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

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IFN beta Antibody (324001) in ELISA

BMC microbiology 2015 - Fig. 3 Cytokine induction in BMDM infected with C. pneumoniae strains AO3 or AR39. BMDMs were prepared as described in the Methods. The cells were infected with AO3 or AR39 at the indicated MOI, and incubated at 35 degC or 37 degC. Supernatant was harvested at 24 h post infection and assayed for ( a ) IL-1beta, ( b ) IL-6 and ( c ) IFN-beta. Graphs depict the mean +- SEM, and are representative of 3 indepen... View More

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产品信息

324001

应用

建议稀释比

已发表文章

酶联免疫吸附实验 (ELISA)

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中和实验 (Neu)

Assay-dependent

产品规格

种属反应

Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant mouse interferon beta

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

Conc. Not Determined

保存液

whole serum, PBS

内含物

no preservative

保存条件

-80°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

AB_223494

产品详细信息

Specificity: Neutralizes mouse interferon beta.

Activity: 1.55x10^6 NU/mL. Interferon was titrated with the use of the cytopathic effect inhibition assay using L929 cells with EMCV, where 2.5 unit/mL of interferon was necessary to produce an endpoint of 50%. One neutralization unit is defined as the amount of serum required to neutralize one unit of mouse IFN beta to an endpoint of 50%.

For retention of full activity, do not store above -70°C.

Packaged by and distributed for PBL Assay Science.

靶标信息

Type I Interferons (IFN-alpha/beta) are produced primarily in response to viral infection by Natural IFN-producing cells (IPCs) as part of the host immune response. IFNs can also inhibit the development of tumors. IFN-beta binding results in the activation of the tyrosine kinases Jak1 and Tyk2, phosphorylation of members of the STAT family of transcription factors, and the transcription and expression of the immune response genes. More recently, several members of the toll-like receptor (TLR) family were found to stimulate the production IFN-beta. IFN-beta is currently used clinically for treatment of tumors, infections and multiple sclerosis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。