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          Disclaimer

          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • Insulin Antibodies

          NeoBiotechnologies

          Insulin/IRDN (beta-Cell and Insulinoma Marker) Monoclonal Antibody (E2-E3, 2D11-H5 (INS04, INS05))

          查看其他44个Insulin抗体

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          说明书
          实验方案
          问题与答案
          技术支持

          Cite Insulin/IRDN (beta-Cell and Insulinoma Marker) Monoclonal Antibody (E2-E3, 2D11-H5 (INS04, INS05))

          • 抗体检测数据 (2)
          Insulin/IRDN (beta-Cell and Insulinoma Marker) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.
          Insulin/IRDN (beta-Cell and Insulinoma Marker) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          图: 1 / 2

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          Insulin/IRDN (beta-Cell and Insulinoma Marker) Antibody (3630-MSM3-P0) in IHC (P)

          Formalin-fixed, paraffin-embedded human Pancreas stained with Insulin Mouse Monoclonal Antibody (E2-E3+2D11-H5). {{ $ctrl.currentElement.advancedVerification.fullName }} 验证信息 View more
          已发表图片由___提供 benchsci-logo
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          查看产品

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          Insulin/IRDN (beta-Cell and Insulinoma Marker) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Insulin/IRDN (beta-Cell and Insulinoma Marker) Antibody in SDS-PAGE (SDS-PAGE)
          Insulin/IRDN (beta-Cell and Insulinoma Marker) Monoclonal Antibody (E2-E3, 2D11-H5 (INS04, INS05))

          产品信息

          3630-MSM3-P0

          应用
          建议稀释比
          已发表文章

          免疫组化(石蜡) (IHC (P))

          Assay-dependent
          -

          免疫组织化学(多聚甲醛固定) (IHC (PFA))

          1-2 µg/mL
          -
          产品规格

          种属反应

          Bovine, Human, Mouse, Pig, Rabbit

          宿主/亚型

          Mouse / IgG1, kappa

          分类

          Monoclonal

          类型

          Antibody

          克隆号

          E2-E3, 2D11-H5 (INS04, INS05)

          抗原

          Purified pig insulin, conjugated to KLH (E2-E3 & 2D11-H5)
          查看免疫原

          偶联物

          Unconjugated Unconjugated Unconjugated

          形式

          Liquid

          浓度

          200 µg/mL

          纯化类型

          Protein A/G

          保存液

          PBS, pH 7.4, with 0.05% BSA

          内含物

          0.05% sodium azide

          保存条件

          4°C, do not freeze

          运输条件

          Ambient (domestic); Wet ice (international)

          靶标信息

          Insulin is a peptide hormone secreted by beta cells of the pancreatic islets. It regulates carbohydrate, protein and lipid metabolism by enhancing membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Insulin is 51-amino acid polypeptide product produced from a precursor peptide, proinsulin. Proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds and one molecule of C-peptide. Insulin deficiency results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of b-cell origin such as insulinoma.

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

          篇参考文献 (0)

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          引用该产品

          生物信息学

          蛋白别名: Ins; Insulin; Insulin-1; Insulin-2; preproinsulin; proinsulin

          查看更多 收起

          基因别名: AA986540; IDDM; IDDM1; IDDM2; ILPR; INS; Ins-1; Ins-2; Ins1; Ins2; Ins2-rs1; InsII; IRDN; Mody; MODY10; Mody4; proinsulin

          查看更多 收起

          UniProt ID: (Pig) P01315, (Human) P01308, (Mouse) P01325, (Mouse) P01326

          查看更多 收起

          Entrez Gene ID: (Pig) 397415, (Bovine) 280829, (Rabbit) 100009181, (Human) 3630, (Mouse) 16333, (Mouse) 16334

          查看更多 收起

          功能
          protease binding insulin receptor binding insulin-like growth factor receptor binding hormone activity identical protein binding protein binding chaperone binding protein complex binding growth factor
          参与通路
          negative regulation of acute inflammatory response glucose metabolic process regulation of cellular amino acid metabolic process acute-phase response G-protein coupled receptor signaling pathway positive regulation of cell proliferation insulin receptor signaling pathway lipid biosynthetic process glycoprotein biosynthetic process positive regulation of nitric oxide mediated signal transduction positive regulation of glucose metabolic process positive regulation of phosphatidylinositol 3-kinase signaling lactate biosynthetic process regulation of transmembrane transporter activity positive regulation of cell migration positive regulation of protein autophosphorylation activation of protein kinase B activity negative regulation of NAD(P)H oxidase activity wound healing lipoprotein biosynthetic process negative regulation of protein catabolic process glucose homeostasis positive regulation of MAPK cascade negative regulation of gluconeogenesis positive regulation of fatty acid biosynthetic process positive regulation of glycogen biosynthetic process positive regulation of DNA replication negative regulation of glycogen catabolic process positive regulation of glycolytic process positive regulation of mitotic nuclear division negative regulation of proteolysis negative regulation of fatty acid metabolic process positive regulation of glucose import positive regulation of insulin receptor signaling pathway alpha-beta T cell activation negative regulation of protein secretion positive regulation of cytokine secretion positive regulation of peptidyl-tyrosine phosphorylation negative regulation of lipid catabolic process positive regulation of lipoprotein lipase activity positive regulation of NF-kappaB transcription factor activity positive regulation of protein kinase B signaling fatty acid homeostasis negative regulation of respiratory burst involved in inflammatory response positive regulation of respiratory burst positive regulation of protein localization to nucleus positive regulation of dendritic spine maintenance regulation of protein localization to plasma membrane negative regulation of reactive oxygen species biosynthetic process response to L-arginine neuron projection maintenance negative regulation of feeding behavior signal transduction feeding behavior protein secretion response to heat response to glucose positive regulation of gene expression response to nutrient levels positive regulation of insulin secretion response to food negative regulation of appetite positive regulation of mammary gland epithelial cell proliferation positive regulation of Rho protein signal transduction estradiol secretion negative regulation of apoptotic process glucose import in response to insulin stimulus positive regulation of protein secretion response to growth hormone positive regulation of peptide hormone secretion positive regulation of cell maturation negative regulation of lactation positive regulation of lactation positive regulation of blood circulation response to butyrate MAPK cascade regulation of transcription, DNA-templated ER to Golgi vesicle-mediated transport cell-cell signaling glucose transport positive regulation of cell growth positive regulation of cellular protein metabolic process negative regulation of protein oligomerization regulation of protein localization cellular protein metabolic process positive regulation of nitric oxide biosynthetic process positive regulation of cell differentiation negative regulation of vasodilation positive regulation of vasodilation positive regulation of lipid biosynthetic process regulation of protein secretion positive regulation of nitric-oxide synthase activity positive regulation of brown fat cell differentiation negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway carbohydrate metabolic process negative regulation of transcription from RNA polymerase II promoter activation of MAPK activity ER overload response activation of JUN kinase activity myoblast fusion regulation of gene expression myotube differentiation lipid catabolic process regulation of phosphorylation regulation of protein binding positive regulation of phosphatidylinositol 3-kinase activity canonical Wnt signaling pathway intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
          It has to be done as per old AB suggested Products section.
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