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Invitrogen
JSRP1 Monoclonal Antibody (VF1c)
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产品信息
MA3-933
产品规格
种属反应
Dog,
Guinea pig,
Mouse,
Rabbit,
Rat
已发表种属
Pig,
Rabbit
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
VF1c
抗原
Rabbit skeletal muscle triads.
偶联物
形式
Liquid
浓度
Conc. Not Determined
保存液
ascites
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA3-933 detects the junctional sarcoplasmic reticulum (SR) protein from rabbit and guinea pig; moderately in canine and rat; and weakly in mouse.
MA3-933 has been successfully used in Western blot and immunofluorescence procedures. By Western blot, this antibody detects an ~90 kDa protein representing junctional SR in rabbit skeletal muscle extracts. Immunofluorescence staining of junctional sarcoplasmic reticulum with MA3-933 results in an increase in intensity in fast (Type II) skeletal muscle over slow (Type I) skeletal muscle, and does not cross-react with cardiac muscle.
The MA3-933 antigen is rabbit skeletal muscle triads.
靶标信息
The junction between the transverse tubules (T-tubules) and the sarcoplasmic reticulum (SR) of skeletal muscle is called the triad. At the triad, dihydropyridine receptors (DHPR) of the T-tubule serve as voltage sensors in excitation-contraction coupling, while ryanodine receptors (RyR), the calcium release channels, exist in the membrane of the terminal cisternae of the SR. It is thought that during slow phase depolarization of the T-tubule, a third protein, triadin (95 kDa) transmits electrochemical signals to the SR through direct interaction with both DHPR and RyR. Another skeletal muscle specific 90 kDa protein has also been localized to the this junction. This protein is phosphorylated by an intrinsic protein kinase in triads suggesting that it may play an important regulatory or structural role in the skeletal muscle triad junction.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: junctional sarcoplasmic reticulum protein 1; Junctional SR; junctional-face membrane protein of 45 kDa homolog
基因别名: 2300003C06Rik; 2310032K21Rik; JP-45; JP45
Entrez Gene ID: (Dog) 612184, (Rat) 690423, (Mouse) 71912
