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Invitrogen
MBL2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-110650
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.1 mg/mL
规格
10 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: DGDSSLAASE RKALQTEMAR IKKWLTFSLG KQVGNKFFLT NGEIMTFEKV KALCVKFQAS VATPRNAAEN GAIQNLIKEE AFLGITDEKT EGQFVDLTGN RLTYTNWNEG EPNNAGSDED CVLLLKNGQW NDVPCSTSH
Highest antigen sequence indentity to the following orthologs: Mouse - 56%, Rat - 54%.
靶标信息
MBL2 is a calcium-dependent lectin involved in innate immune defense. It binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. It also binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. MBL2 may bind DNA.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: activates complement system; collectin-1; Collectin1; mannan-binding lectin; mannose-binding lectin (protein C) 2, soluble (opsonic defect); mannose-binding lectin 2, soluble (opsonic defect); MBPC; MGC116832; MGC116833
基因别名: COLEC1; HSMBPC; MBL; MBL2D; MBP; MBP-C; MBP1; MBPD
UniProt ID: (Human) P11226
Entrez Gene ID: (Human) 4153
complement activation, lectin pathway
cell surface pattern recognition receptor signaling pathway
proteolysis
acute-phase response
response to oxidative stress
opsonization
defense response to bacterium
surfactant homeostasis
innate immune response
negative regulation of viral process
positive regulation of phagocytosis
defense response to Gram-positive bacterium
antiviral innate immune response
positive regulation of opsonization
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
