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Invitrogen
NFATC3 Recombinant Rabbit Monoclonal Antibody (4J7N7)
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FIGURE: 1 / 3
NFATC3 Antibody (MA568913) in IHC (P)
Immunohistochemistry analysis of NFATC3 on paraffin-embedded Mouse thymus tissue. Samples were incubated with NFATC3 recombinant monoclonal antibody (Product # MA568912) using a dilution of 1:400 (40x lens). Followed by a further incubation with Cy3 Goat Anti-Rabbit IgG (H+L) using a dilution of 1:500 (Red). DAPI was used for nuclear staining (Blue). Perform high pressure antigen retrieval with 0. 01 M citr... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA568913
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
4J7N7
Immunogen
Recombinant protein (or fragment).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.58 mg/mL
Amount
11.6 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3., with 50% glycerol, 0.05% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alternative splicing form; NF-AT4; NF-ATc3; NFAC3; NFC3; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3; T cell transcription factor NFAT4; T-cell transcription factor NFAT4; transcription factor; unnamed protein product
Gene Aliases: D8Ertd281e; n339260; NF-AT4c; NFAT4; NFATX
UniProt ID: (Human) Q12968, (Rat) A0A0G2JTY4
Entrez Gene ID: (Human) 4775, (Mouse) 18021, (Rat) 361400
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific double-stranded DNA binding
transcription regulatory region sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding
chromatin binding
sequence-specific DNA binding
negative regulation of transcription from RNA polymerase II promoter
patterning of blood vessels
response to hypoxia
blood vessel remodeling
regulation of transcription, DNA-templated
protein import into nucleus
heart development
positive regulation of cardiac muscle hypertrophy
cardiac muscle hypertrophy in response to stress
myotube differentiation
myotube cell development
T cell differentiation
calcineurin-NFAT signaling cascade
positive regulation of apoptotic process
positive thymic T cell selection
cellular respiration
positive regulation of nitric oxide biosynthetic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
thymus development
skeletal muscle fiber development
smooth muscle cell differentiation
muscle cell development
cellular response to metal ion
cellular response to calcium ion
cellular response to lithium ion
negative regulation of pri-miRNA transcription from RNA polymerase II promoter
DN4 thymocyte differentiation
negative regulation of vascular smooth muscle cell differentiation
positive regulation of artery morphogenesis
regulation of store-operated calcium entry
regulation of transcription from RNA polymerase II promoter
inflammatory response
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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