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Proteintech
PHGDH Recombinant Rabbit Monoclonal Antibody (5L16)
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产品信息
81986-1-RR
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
Mammalian cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
5L16
抗原
Recombinant protein
偶联物
形式
Liquid
纯化类型
Protein A
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
产品详细信息
Immunogen sequence: SFGVQQLPLE EIWPLCDFIT VHTPLLPSTT GLLNDNTFAQ CKKGVRVVNC ARGGIVDEGA LLRALQSGQC AGAALDVFTE EPPRDRALVD HENVISCPHL GASTKEAQSR CGEEIAVQFV DMVKGKSLTG VVNAQALTSA FSPHTKPWIG LAEALGTLMR AWAGSPKGTI QVITQGTSLK NAGNCLSPAV IVGLLKEASK QADVNLVNAK LLVKEAGLNV TTSHSPAAPG EQGFGECLLA VALAGAPYQA VGLVQGTTPV LQGLNGAVFR PEVPLRRDLP LLLFRTQTSD PAMLPTMIGL LAEAGVRLLS YQTSLVSDGE TWHVMGISSL LPSLEAWKQH VTEAFQFHF
靶标信息
PHGDH gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 2-oxoglutarate reductase; 3-PGDH; 3-phosphoglycerate dehydrogenase; 3-phosphoglycerate dehyrogenase; A10; D-3-phosphoglycerate dehydrogenase; epididymis secretory protein Li 113; Malate dehydrogenase
基因别名: 3-PGDH; 3PGDH; 4930479N23; A10; HEL-S-113; NLS; NLS1; PDG; PGAD; PGD; PGDH; PGDH3; PHGDH; PHGDHD; SERA
UniProt ID: (Human) O43175, (Mouse) Q61753, (Rat) O08651
Entrez Gene ID: (Human) 26227, (Mouse) 236539, (Rat) 58835
glutamine metabolic process
glycine metabolic process
L-serine biosynthetic process
threonine metabolic process
brain development
serine family amino acid biosynthetic process
gamma-aminobutyric acid metabolic process
regulation of gene expression
taurine metabolic process
spinal cord development
glial cell development
neural tube development
neuron projection development
oxidation-reduction process
G1 to G0 transition
L-serine metabolic process
metabolic process
cellular amino acid biosynthetic process
neurogenesis
