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PITX2 Polyclonal Antibody

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PITX2 Polyclonal Antibody

产品信息

OSP00157W-100UL

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:300-1:2,000
-

免疫组化 (IHC)

1:300-1:2,000
-

其他PubMed (Misc)

-
查看2篇已发表文章 2篇已发表文章
产品规格

种属反应

Mouse

宿主/亚型

Rabbit / Ig

分类

Polyclonal

类型

Antibody

抗原

A synthetic peptide from aa region 20-70 of mouse Pituitary homeobox 2 conjugated to an immunogenic carrier protein was used as the antigen
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

Conc. Not Determined

保存液

whole serum

内含物

no preservative

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitute in 100 µL of MQ water. Centrifuge to remove any insoluble material.

Specificity of this antibody: PITX2.

靶标信息

Pilx2 is a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. This protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. It plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this protein are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: ALL1-responsive protein ARP1; Bicoid-related homeobox protein 1; BRX1 homeoprotein; Homeobox protein PITX2; Orthodenticle-like homeobox 2; Paired-like homeodomain transcription factor 2; paired-like homeodomain transcription factor Munc 30; Pituitary homeobox 2; S a 1 glycoprotein; S a1glycoprotein; S alpha 1 glycoprotein; S α 1 glycoprotein; S α1glycoprotein; Solurshin

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基因别名: 9430085M16Rik; Arp1; Brx1; Brx1b; Munc30; Otlx2; Pitx2; Ptx2; Rgs; Rieg

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UniProt ID: (Mouse) P97474

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Entrez Gene ID: (Mouse) 18741

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功能
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor binding RNA polymerase II activating transcription factor binding RNA polymerase II transcription coactivator activity transcriptional repressor activity, RNA polymerase II transcription factor binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding transcription factor binding chromatin DNA binding identical protein binding protein homodimerization activity sequence-specific DNA binding phosphoprotein binding homeodomain transcription factor
参与通路
negative regulation of transcription from RNA polymerase II promoter patterning of blood vessels vasculogenesis in utero embryonic development neuron migration extraocular skeletal muscle development atrioventricular valve development cardiac neural crest cell migration involved in outflow tract morphogenesis pulmonary myocardium development regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter multicellular organism development determination of left/right symmetry heart development skeletal muscle tissue development myoblast fusion anatomical structure morphogenesis organ morphogenesis Wnt signaling pathway subthalamic nucleus development hypothalamus cell migration pituitary gland development lung development regulation of cell migration embryonic camera-type eye development embryonic hindlimb morphogenesis vascular smooth muscle cell differentiation deltoid tuberosity development regulation of cell proliferation odontogenesis camera-type eye development positive regulation of DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter spleen development embryonic digestive tract morphogenesis cardiac muscle tissue development cardiac muscle cell differentiation atrial cardiac muscle tissue morphogenesis ventricular cardiac muscle cell development digestive system development ventricular septum morphogenesis left lung morphogenesis pulmonary vein morphogenesis superior vena cava morphogenesis endodermal digestive tract morphogenesis iris morphogenesis cell proliferation involved in outflow tract morphogenesis left/right axis specification positive regulation of myoblast proliferation
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