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Invitrogen
PKN1 Polyclonal Antibody
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图: 1 / 4
PKN1 Antibody (720396) in ICC/IF
For immunofluorescence analysis, HeLa cells were fixed and permeabilized for detection of endogenous PKN1 using Anti- PKN1 Rabbit Polyclonal Antibody (Product # 720396, 5 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of PKN1 protein (green), Panel b) is stained for nuclei (blue) using SlowFade® Gold Antifade Mountant with DAPI (Product # S36938). Panel c) r... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
720396
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptides corresponding to human PKN1 [1) 4-22 2) aa922-aa939]
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2-7.4, with 0.1% BSA, 30% glycerol
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody is predicted to react with Monkey, Bovine, Dog.
靶标信息
PKN1 (PRK1) belongs to the protein kinase C superfamily. This kinase is activated by the Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can also be activated by phospholipids. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: protease-activated kinase 1; protein kinase C-like 1; protein kinase C-like PKN; protein kinase C-related kinase 1; protein kinase PKN-alpha; serine-threonine kinase N; serine/threonine protein kinase N; unnamed protein product
基因别名: DBK; PAK-1; PAK1; PKN; PKN-ALPHA; PRK1; PRKCL1
UniProt ID: (Human) Q16512
Entrez Gene ID: (Human) 5585
chromatin binding
transcription coactivator activity
protein kinase activity
protein serine/threonine kinase activity
protein kinase C activity
protein kinase C binding
protein binding
ATP binding
small GTPase binding
histone kinase activity (H3-T11 specific)
histone binding
histone deacetylase binding
androgen receptor binding
protein serine kinase activity
chromatin remodeling
regulation of transcription from RNA polymerase II promoter
protein phosphorylation
signal transduction
epithelial cell migration
intracellular signal transduction
post-translational protein modification
positive regulation of transcription, DNA-templated
regulation of androgen receptor signaling pathway
regulation of cell motility
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