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Invitrogen
PSMD14 Polyclonal Antibody
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PSMD14 Antibody (38-0200) in ICC/IF
Immunofluorescence analysis of PSMD14 was performed using 70% confluent log phase HepG2 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with PSMD14 Rabbit Polyclonal Antibody (Product # 38-0200) at 5µg/mL in 0.1% BSA and incubated for 3 hours at room temperature and then labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # ... View More
产品信息
38-0200
应用
建议稀释比
已发表文章
产品规格
已发表种属
Rodent
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Raised against the C-term of human POH1.
偶联物
形式
Liquid
浓度
0.25 mg/mL
保存条件
-20°C
运输条件
Wet ice
RRID
靶标信息
The 26S proteasome is responsible for most intracellular proteolysis in eukaryotes. POH1 (also known as Rpn11 in yeast) subunit of the 19S complex is responsible for substrate deubiquitination during proteasomal degradation. POH1 appears to be a Zn21-dependent protease, unlike all other known deubiquitinating enzymes (DUBs) that are cysteine proteases. POH1 was first identified as the human functional homolog of the S. pombe pad1 gene, which confers moderate resistance to chemotherapeutic drugs, and also to ultraviolet light when transiently overproduced in mammalian cells. Poh1-induced drug resistance is mediated through AP-1 transcription factors.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
