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RARA/RARB/RARG Recombinant Rabbit Monoclonal Antibody (PSH08-74)

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RARA/RARB/RARG Recombinant Rabbit Monoclonal Antibody (PSH08-74)

产品信息

MA570053

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000-1:5,000
-
产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

PSH08-74

抗原

Recombinant protein within human RARG aa 155-454.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

规格

100 µg

纯化类型

Protein A

保存液

PBS, pH 7.4, with 0.1% BSA, 40% glycerol

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Positive control: SK-Br-3 cell lysate, T-47D cell lysate, A375 cell lysate, HeLa cell lysate.

Subcellular location: Nucleus, Cytoplasm.

靶标信息

All three genes are part of the nuclear receptor family and are crucial in regulating cell growth, differentiation, and apoptosis. They share structural similarities, including a DNA-binding domain and a ligand-binding domain, allowing them to bind to specific DNA sequences and regulate target gene expression. RARA (Retinoic Acid Receptor Alpha) is a nuclear receptor that mediates the effects of retinoic acid (a metabolite of vitamin A) by regulating gene transcription. It is located on chromosome 17q21.2. RARB (Retinoic Acid Receptor Beta) also functions as a nuclear receptor for retinoic acid and is involved in gene activation. It is located on chromosome 3p24. RARG (Retinoic Acid Receptor Gamma) plays a similar role in mediating retinoic acid effects and is found on chromosome 12q13.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: HBV-activated protein; hepatitis B virus activated protein; nuclear receptor; Nuclear receptor subfamily 1 group B member 1; Nuclear receptor subfamily 1 group B member 2; Nuclear receptor subfamily 1 group B member 3; nuclear receptor; RAR beta; nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form; open reading frame 1; putative; PML gene product; PML-DDX5-RARA fusion; PML-DDX5-RARA fusion protein; RAR beta 1'; RAR-alpha; RAR-beta; RAR-epsilon; RAR-gamma; RARA; RARB; RARbeta isoform 5; Retinoic acid receptor alpha; Retinoic acid receptor beta; Retinoic acid receptor gamma; retinoic acid receptor gamma 2; retinoic acid receptor, alpha polypeptide; retinoic acid receptor, beta polypeptide; TTMV/RARA fusion; TTMV/RARA fusion protein; unnamed protein product

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基因别名: HAP; MCOPS12; NR1B1; NR1B2; NR1B3; RAR; RARA; RARalpha; RARB; RARbeta; RARbeta1; RARC; RARG; RARgamma; RRB2

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UniProt ID: (Human) P10276, (Human) P10826, (Human) P13631

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Entrez Gene ID: (Human) 5914, (Human) 5915, (Human) 5916

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功能
translation repressor activity, nucleic acid binding transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding transcription coactivator binding retinoic acid binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding receptor binding protein binding zinc ion binding enzyme binding protein domain specific binding chromatin DNA binding histone deacetylase binding protein kinase B binding sequence-specific DNA binding retinoic acid-responsive element binding metal ion binding mRNA 5'-UTR binding protein kinase A binding alpha-actinin binding heterocyclic compound binding sequence-specific double-stranded DNA binding macromolecular complex binding retinoid X receptor binding
参与通路
negative regulation of transcription from RNA polymerase II promoter ureteric bud development neural tube closure liver development glandular epithelial cell development outflow tract septum morphogenesis growth plate cartilage development regulation of transcription, DNA-templated protein phosphorylation germ cell development spermatogenesis female pregnancy positive regulation of cell proliferation negative regulation of cell proliferation male gonad development positive regulation of gene expression negative regulation of gene expression negative regulation of translation hippocampus development cell differentiation prostate gland development regulation of granulocyte differentiation negative regulation of granulocyte differentiation embryonic camera-type eye development regulation of myelination response to estradiol response to retinoic acid negative regulation of interferon-gamma production negative regulation of tumor necrosis factor production positive regulation of interleukin-13 production positive regulation of interleukin-4 production positive regulation of interleukin-5 production response to vitamin A response to cytokine multicellular organism growth mRNA transcription from RNA polymerase II promoter regulation of apoptotic process negative regulation of apoptotic process apoptotic cell clearance response to ethanol negative regulation of cell differentiation positive regulation of T-helper 2 cell differentiation positive regulation of neuron differentiation positive regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of synaptic plasticity retinoic acid receptor signaling pathway positive regulation of binding ventricular cardiac muscle cell differentiation Sertoli cell fate commitment limb development face development bone development trachea cartilage development chondroblast differentiation negative regulation of cartilage development cellular response to lipopolysaccharide cellular response to retinoic acid cellular response to estrogen stimulus nucleus-associated proteasomal ubiquitin-dependent protein catabolic process regulation of hematopoietic progenitor cell differentiation negative regulation of pri-miRNA transcription from RNA polymerase II promoter chondrocyte development growth plate cartilage chondrocyte growth apoptotic process cell proliferation regulation of cell size anterior/posterior pattern specification regulation of gene expression programmed cell death negative regulation of chondrocyte differentiation embryonic hindlimb morphogenesis positive regulation of apoptotic process positive regulation of programmed cell death regulation of myeloid cell differentiation embryonic eye morphogenesis reproductive structure development gland development canonical Wnt signaling pathway bone morphogenesis epithelium development prostate gland epithelium morphogenesis Harderian gland development stem cell proliferation cellular response to leukemia inhibitory factor negative regulation of stem cell proliferation signal transduction striatum development neurogenesis embryonic digestive tract development neural precursor cell proliferation
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