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Proteintech
RIC8A Polyclonal Antibody
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产品信息
11138-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
RIC8A Fusion Protein Ag1593 (117-467 aa encoded by BC011821)
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: QQLFQELKG VRLLTDTLEL TLGVTPEGNP PTLLPSQETE RAMEILKVLF NITLDSIKGE VDEEDAALYR HLGTLLRHCV MIATAGDRTE EFHGHAVNLL GNLPLKCLDV LLTLEPHGDS TEFMGVNMDV IRALLIFLEK RLHKTHRLKE SVAPVLSVLT ECARMHRPAR KFLKAQVLPP LRDVRTRPEV GEMLRNKLVR LMTHLDTDVK RVAAEFLFVL CSESVPRFIK YTGYGNAAGL LAARGLMAGG RPEGQYSEDE DTDTDEYKEA KASINPVTGR VEEKPPNPME GMTEEQKEHE AMKLVTMFDK LSRNRVIQPM GMSPRGHLTS LQDAMCETME QQLSSDPDSD PD (117-467 aa encoded by BC011821)
靶标信息
Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Chaperone Ric-8A; heterotrimeric G protein guanine nucleotide exchange factor Ric-8A; MGC104517; MGC131931; MGC148073; MGC148074; resistance to inhibitors of cholinesterase 8 homolog; resistance to inhibitors of cholinesterase 8 homolog A; resistance to inhibitors of cholinesterase 8A; RIC8 protein; synembryn; Synembryn-A
基因别名: AI114950; RIC-8; Ric-8A; RIC8; RIC8A
UniProt ID: (Human) Q9NPQ8, (Mouse) Q3TIR3, (Rat) Q80ZG1
Entrez Gene ID: (Human) 60626, (Mouse) 101489, (Rat) 293614
in utero embryonic development
vasculature development
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
gastrulation
visual learning
response to light stimulus
cell migration involved in gastrulation
positive regulation of GTPase activity
cell-cell adhesion involved in gastrulation
basement membrane organization
regulation of G-protein coupled receptor protein signaling pathway
