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FIGURE: 1 / 2
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). Inhibits KAT6B-dependent transcriptional activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Acute myeloid leukemia 1 protein; Acute myeloid leukemia 3 protein; AKV core binding factor; aml1; AML1-ETO fusion; AML1-ETO fusion protein; AML1-EVI-1 fusion protein; CBF-alpha-1; CBF-alpha-2; core binding factor alpha 1; core binding factor alpha 2; core-binding factor runt domain alpha subunit 2 (acute myeloid leukemia 1 oncogene); Core-binding factor subunit alpha-1; Core-binding factor subunit alpha-2; core-binding factor, runt domain, alpha subunit 1; core-binding factor, runt domain, alpha subunit 2; mutant RUNX1; Oncogene AML-1; Oncogene AML-3; OSF-2; Osteoblast-specific transcription factor 2; PEA2-alpha A; PEA2-alpha B; PEBP2 alpha A; PEBP2-alpha A; PEBP2-alpha B; Polyomavirus enhancer-binding protein 2 alpha A subunit; Polyomavirus enhancer-binding protein 2 alpha B subunit; runt domain, alpha subunit 1; runt domain, alpha subunit 2; runt related transcription factor 1; runt related transcription factor 2; runt-related factor 2; Runt-related transcription factor 1; Runt-related transcription factor 2; RUNX1 with skipped exon 5; SL3-3 enhancer factor 1 alpha A subunit; SL3-3 enhancer factor 1 alpha B subunit; SL3/AKV core-binding factor alpha A subunit; SL3/AKV core-binding factor alpha B subunit
Gene Aliases: AML1; AML1-EVI-1; AML3; AMLCR1; Cbf; CBF-alpha-1; CBF-alpha-2; CBF2alpha; Cbfa-1; CBFA1; CBFA2; CCD; CCD1; CLCD; EVI-1; LS3; OSF-2; OSF2; PEA2aA; PEBP2A; Pebp2a1; Pebp2a2; PEBP2aA; PEBP2aB; PEBP2alpha; Pebpa2a; Pebpa2b; RUNX1; RUNX2
UniProt ID: (Human) Q01196, (Human) Q13950, (Rat) Q63046, (Mouse) Q08775
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