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Proteintech
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Immunogen sequence: IRSRPPLKQ VSERRLRPLP PKQRSLHEKI LEEIKQERRL RPVRGEGWAA RGFGSLPCIL NACSGDAKST SCINLSVTDA GGSAQRPRPR VLLKAPTLAE MEEMNTSEEE ESPCGEVTLK RDRSFSEHDL AQLRSEVASG LQSATHPPGG TEPPRPRAGS AHVWRPGSRD QGTCPASVSD PSHPLLSNRG SSGDRPEASM TPDAKHLWLE FSHPVESLAL TVEEVMDVRR VLVKAEMEKF LQNKELFSSL KKGKICCCCR AKFPLFSWPP SCLFCKRSLQ GPQWQSVEEA FPHIYSHGCV LKDVCSECTS FVADVVRSSR KSVDVLNTTP RRSRQTQSLY IPNTRTLDFK (318-666 aa encoded by BC111030)
Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: spire actin nucleation factor 2; spire family actin nucleation factor 2; spire homolog 2; unnamed protein product
基因别名: Spir-2; Spir2
UniProt ID: (Human) Q8WWL2, (Mouse) Q8K1S6
Entrez Gene ID: (Human) 84501, (Mouse) 234857, (Rat) 307925