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Invitrogen
STIM1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA1-46217
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Dog,
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide from the C-terminal region (within residues 600-685) of the human STIM1 protein.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 30% glycerol
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The target sequence has 93% sequence homology with porcine and 79% sequence homology with xenopus.
Suggested positive control: antigen standard for STIM1 (transient overexpression lysate), HeLa whole cell lysate.
Target Information
STIM1 (stromal interacting molecule; also known as GOK) acts as a sensor of calcium depletion within the endoplasmic reticulum and transduces the signal to Orai1, the presumptive CRAC channel at the plasma membrane. Following decrease of luminal calcium concentration, STIM1 oligomerizes and induces Orai1 to enable entry of extracellular calcium into the cytoplasm. However, the precise mechanism of STIM1-Orai1 interaction has not been elucidated yet. Many questions also remain to be solved around STIM1 functional distribution. It turns out that STIM1 associates with growing ends of microtubules and is involved in endoplasmic reticulum tubule extension.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: stim1 {ECO:0000312|RGD:1306831}; STIM1L; Stromal interaction molecule 1
Gene Aliases: GOK; SIM; STIM1
UniProt ID: (Bovine) Q58CP9, (Mouse) P70302, (Rat) P84903
Entrez Gene ID: (Dog) 608643, (Bovine) 534816, (Mouse) 20866, (Rat) 361618
store-operated calcium entry
detection of calcium ion
transport
ion transport
cation transport
calcium ion transport
myotube differentiation
activation of store-operated calcium channel activity
regulation of calcium ion transport
calcium ion transmembrane transport
regulation of store-operated calcium entry
positive regulation of adenylate cyclase activity
enamel mineralization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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