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Invitrogen
Thrombin Polyclonal Antibody
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产品信息
PA5-111397
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: EGVWCYVAGK PGDFGYCDLN YCEEAVEEET GDGLDEDSDR AIEGRTATSE YQTFFNPRTF GSGEADCGLR PLFEKKSLE
Highest antigen sequence indentity to the following orthologs: Rat - 65%, Mouse - 68%.
靶标信息
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Coagulation factor II; coagulation factor II (thrombin); prepro-coagulation factor II; Prothombin; Prothrombin; prothrombin B-chain; serine protease
基因别名: F2; PT; RPRGL2; THPH1
UniProt ID: (Human) P00734
Entrez Gene ID: (Human) 2147
positive regulation of protein phosphorylation
signal peptide processing
proteolysis
ER to Golgi vesicle-mediated transport
acute-phase response
cell surface receptor signaling pathway
multicellular organism development
blood coagulation
blood coagulation, intrinsic pathway
positive regulation of cell proliferation
regulation of cell shape
response to wounding
regulation of gene expression
negative regulation of platelet activation
positive regulation of phosphatidylinositol 3-kinase signaling
response to inactivity
peptidyl-glutamic acid carboxylation
platelet activation
regulation of blood coagulation
positive regulation of blood coagulation
positive regulation of cell growth
positive regulation of collagen biosynthetic process
fibrinolysis
cellular protein metabolic process
negative regulation of proteolysis
negative regulation of astrocyte differentiation
leukocyte migration
positive regulation of release of sequestered calcium ion into cytosol
regulation of cytosolic calcium ion concentration
negative regulation of fibrinolysis
cellular response to mechanical stimulus
positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of reactive oxygen species metabolic process
