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Invitrogen
Thrombin Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-84070
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
50 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: FEALESSTAT DVFWAKYTAC ETARTPRDKL AACLEGNCAE GLGTNYRGHV NITRSGIECQ LWRSRYPHKP EINSTTHPGA DLQ
Highest antigen sequence indentity to the following orthologs: Mouse - 71%, Rat - 69%.
靶标信息
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: prepro-coagulation factor II; Prothombin; prothrombin B-chain; thrombin factor II; thrombin precursor; unnamed protein product
基因别名: PT; RPRGL2; THPH1
UniProt ID: (Human) P00734
Entrez Gene ID: (Human) 2147
proteolysis
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
blood coagulation
response to wounding
negative regulation of platelet activation
platelet activation
regulation of blood coagulation
positive regulation of blood coagulation
negative regulation of blood coagulation
zymogen activation
positive regulation of collagen biosynthetic process
fibrinolysis
negative regulation of proteolysis
positive regulation of JAK-STAT cascade
negative regulation of astrocyte differentiation
regulation of body fluid levels
positive regulation of release of sequestered calcium ion into cytosol
regulation of cytosolic calcium ion concentration
negative regulation of fibrinolysis
antimicrobial humoral immune response mediated by antimicrobial peptide
thrombin receptor signaling pathway
neutrophil mediated killing of gram-negative bacterium
blood coagulation, common pathway
negative regulation of cytokine production involved in inflammatory response
positive regulation of protein localization to nucleus
positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of reactive oxygen species metabolic process
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
