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Invitrogen
WBSCR22 Polyclonal Antibody
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产品信息
PA5-62566
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: ELFYDETEAR KYVRNSRMID IQTRMAGRAL ELLYLPENKP CYLLDIGCGT GLSGSYLSDE GHYWVGLDIS PAMLDE
Highest antigen sequence identity to the following orthologs: Mouse - 80%, Rat - 80%.
靶标信息
The WBSCR22 gene, also known as Williams-Beuren Syndrome Chromosome Region 22, encodes a protein that participates in the biogenesis of the 40S ribosomal subunit. This gene is one of the 26 deleted in Williams-Beuren syndrome, which is characterized by cognitive delays, congenital heart and vascular diseases, and distinct facial features. WBSCR22 features a nuclear localization signal and an S-adenosylmethionine (SAM) binding motif typical of methyltransferases. The protein enhances cell survival and proliferation, with increased expression linked to poor prognosis in various cancers, including glioma and breast cancer. WBSCR22 modulates key signaling pathways such as Akt/GSK3B and beta-catenin/CyclinD1, and is a direct target of miR-146b-5p. Moreover, its downregulation suppresses tumor growth, suggesting its potential as a therapeutic target in oncology.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 18S rRNA (guanine-N(7))-methyltransferase; Bud site selection protein 23 homolog; Metastasis-related methyltransferase 1; ribosome biogenesis methyltransferase WBSCR22; rRNA methyltransferase and ribosome maturation factor; Williams Beuren syndrome chromosome region 22; Williams-Beuren candidate region putative methyltransferase; Williams-Beuren syndrome chromosomal region 22 protein
基因别名: BUD23; HASJ4442; HUSSY-03; HUSSY-3; MERM1; PP3381; WBMT; WBSCR22
UniProt ID: (Human) O43709
Entrez Gene ID: (Human) 114049
