Invitrogen

alpha Synuclein Monoclonal Antibody (Syn 211)

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34个已发表图片
63 篇参考文献
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说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
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说明书
实验方案
问题与答案
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产品信息

32-8100

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1-3 µg/mL
查看21篇已发表文章 21篇已发表文章

免疫组化 (IHC)

Assay-dependent
查看14篇已发表文章 14篇已发表文章

免疫组化（石蜡） (IHC (P))

-
查看1篇已发表文章 1篇已发表文章

免疫组织化学（多聚甲醛固定） (IHC (PFA))

-
查看1篇已发表文章 1篇已发表文章

免疫组化（冰冻） (IHC (F))

-
查看2篇已发表文章 2篇已发表文章

免疫组织化学（悬浮细胞） (IHC (Free))

-
查看1篇已发表文章 1篇已发表文章

免疫细胞化学 (ICC/IF)

-
查看12篇已发表文章 12篇已发表文章

酶联免疫吸附实验 (ELISA)

Assay-dependent
-

免疫沉淀 (IP)

-
查看2篇已发表文章 2篇已发表文章

点杂交 (DB)

-
查看4篇已发表文章 4篇已发表文章

亲和纯化 (AP)

-
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其他PubMed (Misc)

-
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产品规格

种属反应

Human

已发表种属

Bacteria, C. elegans, Human, Mouse, Non-human primate, Rat

宿主/亚型

Mouse / IgG1, kappa

分类

Monoclonal

类型

Antibody

克隆号

Syn 211

抗原

Recombinant human alpha-synuclein.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4

内含物

0.1% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2533094

产品详细信息

This antibody reacts with the alpha-synuclein protein. This antibody does not cross-react with beta- or gamma-synuclein or synoretin. During development reactivity was confirmed with human. Reactivity with other species has not been tested.

靶标信息

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein have been shown to selectively inhibit phospholipase D2, suggesting that they may also be involved in signaling pathways. Defects in the SNCA gene, which encodes alpha-synuclein, have been implicated in the pathogenesis of Parkinson's disease. Additionally, alpha-synuclein peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene. Diseases associated with SNCA include Parkinson Disease 1, Autosomal Dominant and Dementia, Lewy Body.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: Alpha synuclein; Alpha-synuclein; NACP; non A-beta component of AD amyloid; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; synuclein alpha-140; synuclein, alpha (non A4 component of amyloid precursor)

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基因别名: NACP; PARK1; PARK4; PD1; SNCA

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UniProt ID: (Human) P37840

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Entrez Gene ID: (Human) 6622

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功能
magnesium ion binding fatty acid binding copper ion binding calcium ion binding protein binding phospholipid binding microtubule binding ferrous iron binding zinc ion binding oxidoreductase activity kinesin binding protein domain specific binding histone binding identical protein binding alpha-tubulin binding cysteine-type endopeptidase inhibitor activity involved in apoptotic process phospholipase binding transcription regulatory region DNA binding dynein binding protein N-terminus binding tau protein binding beta-tubulin binding phosphoprotein binding phospholipase D inhibitor activity membrane trafficking regulatory protein
参与通路
negative regulation of transcription from RNA polymerase II promoter microglial cell activation positive regulation of receptor recycling negative regulation of protein phosphorylation positive regulation of neurotransmitter secretion fatty acid metabolic process neutral lipid metabolic process phospholipid metabolic process apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process mitochondrial membrane organization aging adult locomotory behavior response to iron(II) ion regulation of phospholipase activity negative regulation of platelet-derived growth factor receptor signaling pathway regulation of glutamate secretion regulation of dopamine secretion negative regulation of microtubule polymerization receptor internalization protein destabilization response to magnesium ion negative regulation of transporter activity response to lipopolysaccharide negative regulation of monooxygenase activity positive regulation of peptidyl-serine phosphorylation response to interferon-gamma cellular response to oxidative stress negative regulation of histone acetylation regulation of locomotion dopamine biosynthetic process response to drug mitochondrial ATP synthesis coupled electron transport regulation of macrophage activation positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process extracellular fibril organization negative regulation of neuron apoptotic process cellular protein metabolic process cellular response to fibroblast growth factor stimulus positive regulation of endocytosis negative regulation of exocytosis negative regulation of dopamine metabolic process behavioral response to cocaine regulation of long-term neuronal synaptic plasticity synaptic vesicle endocytosis synapse organization regulation of acyl-CoA biosynthetic process positive regulation of release of sequestered calcium ion into cytosol dopamine uptake involved in synaptic transmission negative regulation of dopamine uptake involved in synaptic transmission negative regulation of serotonin uptake negative regulation of norepinephrine uptake calcium ion homeostasis oxidation-reduction process excitatory postsynaptic potential long-term synaptic potentiation positive regulation of inositol phosphate biosynthetic process negative regulation of thrombin receptor signaling pathway response to interleukin-1 cellular response to copper ion cellular response to epinephrine stimulus positive regulation of protein serine/threonine kinase activity negative regulation of neuron death negative regulation of mitochondrial electron transport, NADH to ubiquinone positive regulation of glutathione peroxidase activity positive regulation of hydrogen peroxide catabolic process regulation of synaptic vesicle recycling regulation of reactive oxygen species biosynthetic process negative regulation of chaperone-mediated autophagy
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